Adam de la Zerda: We can start winning the war against cancer
Адам де ла Зерда: Ми можемо почати вигравати війну з раком
Adam de la Zerda develops new medical imaging technologies to detect and destroy cancer. Full bio
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and the National Cancer Institute declared
Ракових Досліджень оголосили це
but I don't buy that.
та я на це не повівся.
виграли цю війну,
що хтось сумнівається в цьому.
anyone here will question that.
війну проти раку,
this war against cancer
мого друга.
a story about a good friend of mine.
в Ехуда діагностували рак мозку.
Ehud was diagnosed with brain cancer.
раку мозку:
найсмертельнішу форму раку мозку.
of the most deadly forms of brain cancer.
лише 12 місяців,
that they only have 12 months,
вони мали знайти лікування.
they have to find a treatment.
він помре.
find a cure, he will die.
з яких можна вибирати,
of different treatments to choose from,
if a treatment is even working or not,
about three months or so.
перше лікування,
into his first treatment,
кількох днів курсу,
just a few days into that treatment,
"Адаме, я думаю, це допомагає.
"Adam, I think this is working.
Щось відбувається."
Something is happening."
Як ти про це знаєш, Ехуде?"
How do you know that, Ehud?"
I feel so terrible inside.
ми дізнались, що це не подіяло.
we got the news, it didn't work.
into his second treatment.
gotta be working there."
отримали погані новини.
again we get bad news.
а потім і четвертий курс.
and then his fourth treatment.
таку відчайдушну боротьбу,
is going through such a huge struggle,
через вашу голову.
are going through your head.
що ми зможемо запропонувати?
this is the best that we can offer?
дедалі більше подібного матеріалу.
more and more into this.
варіант, який могли запропонувати.
the best that doctors could offer Ehud.
запропонувати пацієнту з пухлиною мозку.
patients with brain cancer generally.
справляємось взагалі із раком мозку.
all across the board with cancer.
статистичних даних,
вже бачив цю статистику,
have seen those statistics before.
пацієнтів померли від раку,
how many patients actually died of cancer,
не так багато речей.
that many things that have changed.
кількість випадків раку легенів.
for example, on the rise.
рак шлунку,
for example, stomach cancer
серед ракових хвороб,
of the biggest killers of all cancers,
До речі, хтось здогадується?
Anyone knows, by the way?
шлунку?
struck by stomach cancer?
медичний прорив,
medical technology breakthrough
людство від раку шлунку?
that saved humanity from stomach cancer?
or a better diagnostic?
чи краща діагностика?
більше зіпсовану їжу.
no longer eating spoiled meats.
that happened to us so far
ракових досліджень -
холодильника.
the refrigerator was invented.
із цим справляємось.
прогресу
в ракових дослідженнях.
in cancer research.
раку, які за 50 років
of good cancer research
речей про рак.
that taught us about cancer.
ще чимало тяжкої роботи.
to still do ahead of us.
reason why this is the case,
що основна причина того,
сканування.
medical imaging comes in.
про найкраще медичне сканування,
of the best medical imaging
пацієнтам з раком мозку
to brain cancer patients,
на рак,
to all cancer patients,
на знімок томографії.
скан,
зображенні можна побачити,
where the bones are,
де пухлина.
where tumors are.
значок,
за межі тіла.
outside of the body,
цим пацієнтам мільйонами ,
into these patients by the billions,
які бажають цукру.
that are hungry for sugar.
for example, lights up there.
тут, світиться серце.
чимало цукру.
needs a lot of sugar.
lights up there.
очищає
is the thing that's clearing
a wonderful technology.
заглянути в чиєсь тіло,
to look into someone's body
клітиною,
each and every one of the cells
заглянути в чиєсь тіло
allowing us to look into someone's body
чи є метастази?"
has the cancer metastasized?
are showing you very clearly
де пухлина.
where is the tumor.
як і виглядає,
оці маленькі точки тут.
small little hot spots there.
ракових клітин в цих пухлинах?
are in any one of these tumors?
що ви зрозуміли.
that this number sunk in.
спалахів,
of these small little blips
ракових клітин,
at least 100 million cancer cells
like a very large number,
an incredibly large number,
щоб це досить рано побачити,
in order to pick up something early enough
вплинути на це,
to do something meaningful about it,
розміром із тисячу клітин,
that are a thousand cells in size,
a handful of cells in size.
pretty far away from this.
невеличкий експеримент.
a little experiment here.
to now play and imagine
що пухлини вже немає.
that the tumor is out.
have already been removed,
приблизно з м'ячик для гольфу,
about the size of a golf ball or so
його мозку.
of this person's brain.
все однакове на вигляд,
everything looks the same,
та здорова тканина мозку
and healthy brain tissue
a little bit on the brain,
щільніші, твердіші,
a little harder, stiffer,
і врешті говорите:
a little bit like this and say,
різати пухлину
and start cutting the tumor
і роздумуєте:
to a stage where you think,
Я все вийняв."
I took out everything."
досить божевільно --
like, pretty crazy --
рішенням у своєму житті.
challenging decision of your life here.
і відпустити пацієнта,
and let this patient go,
залишитись ракові клітини,
some leftover cancer cells behind
навколо пухлини
around the tumor
що я вирізав все?
приймати кожного дня,
have to take every single day
друзями в лабораторії,
to a few friends of mine in the lab,
має бути кращий спосіб."
there's got to be a better way."
що, можливо, є кращий спосіб.
that there's got to be a better way.
я вам говорив про них.
the sugar and so on.
замість молекул цукру
instead of using sugar molecules,
частини золота,
little particles made of gold,
цікавий хімічний зв'язок.
interesting chemistry around them.
шукати ракові клітини.
to look for cancer cells.
мільйони
these gold particles
до кожної клітини тіла
every single cell in our body
чи здорова клітина?"
or are you a healthy cell?
ми йдемо далі.
ми зупинимось тут і станемо блищати,
we're sticking in and shining out
"Погляньте на мене, я тут."
"Hey, look at me, I'm here."
through some interesting cameras
за допомогою незвичних камер,
зможемо показати нейрохірургам,
maybe we can guide brain cancer surgeons
and leaving the healthy brain alone.
і облишити здорову тканину мозку.
що це працює.
and boy, this works well.
into this mouse's brain
growing in this mouse's brain,
і попросили його
and asked the doctor
як справжнього пацієнта,
as if that was a patient,
out of the tumor.
де саме розташувались золоті частинки.
to see where the gold particles are.
в мишу,
into this mouse,
що ось тут справа і он там зліва
right here at the very left there
золоті частинки.
where the gold particles are.
хороші тим,
is that these gold particles
до пухлини,
"Гей, ми тут. Ось пухлина."
"Hey, we're here. Here's the tumor."
to the doctor yet.
почати вирізати пухлину,
now please start cutting away the tumor,
забирає перший сектор пухлини,
just took the first quadrant of the tumor
is now missing.
третій,
the second quadrant, the third,
і запитав:
the doctor came back to us and said,
What do you want me to do?
по краях?"
some extra margins around?"
"ти пропустив ось ці дві точки,
"You've missed those two spots,
а тоді поглянь."
and then let's take a look."
і ось,
and lo and behold,
that the cancer is completely gone
величезні шматки здорового мозку
huge amounts of healthy brain
при видаленні пухлини,
as they take away a tumor,
по відчуттях пальця.
have to guess with their thumb.
забрати ці невеличкі залишки.
to take those tiny little leftover tumors.
even if it's just a handful of cells,
видалити рак,
ultimately fail
які залишаються раковими,
extra margins that were left positive,
які все ще там.
that were left there.
з вами тим, що нас провадить далі.
is where I think we're heading from here.
в Стенфорді
над чим нам зараз варто працювати?
what should we be working on now?
сканування
medical imaging is heading to
в людське тіло
та кожну окремо.
of these cells separately.
на набагато раніших етапах,
way, way earlier in the process,
клітин, щоб ми змогли щось зробити.
so we can actually do something about it.
також дозволить нам
of the cells might also allow us
ми добираємось до миті,
we are now getting to a point
раковим клітинам,
these cancer cells real questions,
які ми тобі прописали?
to the treatment we are giving you or not?
що потрібно відразу припинити лікування
to stop the treatment right away,
не за три місяці.
хіміотерапевтичні ліки,
nasty, nasty chemotherapy drugs,
side effects of the drugs
in fact not even helping them.
від перемоги у війні над раком,
from winning the war against cancer,
з кращою технікою медичного сканування,
with better medical imaging techniques
ABOUT THE SPEAKER
Adam de la Zerda - Biologist, electrical engineerAdam de la Zerda develops new medical imaging technologies to detect and destroy cancer.
Why you should listen
Adam de la Zerda is an assistant professor at the Departments of Structural Biology and Electrical Engineering (courtesy) at Stanford University – School of Medicine. He completed his undergraduate degree in computer engineering and physics from the Technion – Israel Institute of Technology in 2005 Summa Cum Laude. He received his Ph.D. in Electrical Engineering from Stanford University in 2011, where he developed the Photoacoustic Molecular Imaging technique with Sanjiv Sam Gambhir. He was then a postdoctoral fellow at the lab of Carolyn Bertozzi at UC Berkeley – Chemistry Department, before joining the Stanford faculty in 2012.
de la Zerda's research interests span the broad field of molecular imaging. His lab focuses on developing new optical imaging instrumentation and chemistry tools to study the complex spatiotemporal behavior of biomolecules in living subjects. The lab uses animal models for cancer and ophthalmic diseases such as age-related macular degeneration. His research efforts span both basic science and clinically translatable work.
de la Zerda has received many awards and honors for his work, including the Pew-Stewart Scholar for Cancer Research, the AFOSR Young Investigator Award, Baxter Faculty Scholar Award, Dale F. Frey Award, Forbes Magazine 30 Under 30 in Science and Healthcare for 2012 and 2014, NIH Director’s Early Independence Award, Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, Era of Hope Distinguished Predoctoral Poster Award, Best Poster Presentation at SPIE Photonics West, the Young Investigator Award at the World Molecular Imaging Congress, the Department of Defense Breast Cancer Research Program Award for Predoctoral researchers, the Bio-X Graduate Student Fellowship and first place at the Bay Area Entrepreneurship Contest. He has published papers in leading journals including Nature Medicine, Nature Nanotechnology and PNAS. He holds a number of patents and is the founder of a medical device company, Click Diagnostics.
Adam de la Zerda | Speaker | TED.com