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TED2009

Nathan Wolfe: The jungle search for viruses

February 5, 2009

Virus hunter Nathan Wolfe is outwitting the next pandemic by staying two steps ahead: discovering deadly new viruses where they first emerge -- passing from animals to humans among poor subsistence hunters in Africa -- before they claim millions of lives.

Nathan Wolfe - Virus hunter
Armed with blood samples, high-tech tools and a small army of fieldworkers, Nathan Wolfe hopes to re-invent pandemic control -- and reveal hidden secrets of the planet's dominant lifeform: the virus. Full bio

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Double-click the English subtitles below to play the video.
When most people think about the beginnings
00:12
of AIDS, they're gonna think back to the 1980s.
00:14
And certainly, this was the decade in which we discovered AIDS
00:17
and the virus that causes it, HIV.
00:20
But in fact this virus crossed over into humans many decades before,
00:23
from chimpanzees, where the virus originated, into humans who hunt these apes.
00:27
This photo was taken before the Great Depression
00:31
in Brazzaville, Congo.
00:34
At this time, there were thousands of individuals,
00:36
we think, that were infected with HIV.
00:38
So I have a couple of really important questions for you.
00:40
If this virus was in thousands
00:42
of individuals at this point,
00:43
why was it the case that it took us until 1984
00:45
to be able to discover this virus?
00:48
OK now, more importantly,
00:50
had we been there in the '40s and '50s, '60s,
00:52
had we seen this disease, had we understood
00:55
exactly what was going on with it, how might that have changed and completely
00:58
transformed the nature of the way this pandemic moved?
01:01
In fact, this is not unique to HIV. The vast majority of
01:06
viruses come from animals.
01:09
And you can kind of think of this as a pyramid of this bubbling up of viruses
01:11
from animals into human populations.
01:14
But only at the very top of this pyramid do these things become completely human.
01:16
Nevertheless, we spend the vast majority
01:19
of our energy focused on this level of the pyramid,
01:22
trying to tackle things that are already completely adapted to human beings,
01:24
that are going to be very very difficult to address --
01:28
as we've seen in the case of HIV.
01:30
So during the last 15 years,
01:32
I've been working to actually study the earlier interface here --
01:34
what I've labeled "viral chatter," which was a term coined
01:37
by my mentor Don Burke.
01:39
This is the idea that we can study the sort of
01:41
pinging of these viruses into human populations,
01:43
the movement of these agents over into humans;
01:46
and by capturing this moment,
01:48
we might be able to move to a situation where we can catch them early.
01:50
OK, so this is a picture, and I'm going to show you
01:53
some pictures now from the field.
01:55
This is a picture of a central African hunter.
01:57
It's actually a fairly common picture.
01:59
One of the things I want you to note from it
02:01
is blood -- that you see a tremendous amount of blood contact.
02:03
This was absolutely key for us. This is a
02:06
very intimate form of connection.
02:08
So if we're going to study viral chatter, we need to
02:10
get to these populations who have intensive contact with wild animals.
02:12
And so we've been studying people like this individual.
02:15
We collect blood from them, other specimens.
02:19
We look at the diseases, which are in the animals as well as the humans.
02:22
And ideally, this is going to allow us to catch these things
02:25
early on, as they're moving over into human populations.
02:28
And the basic objective of this work is not to just
02:31
go out once and look at these individuals,
02:33
but to establish thousands of individuals
02:35
in these populations that we would monitor
02:37
continuously on a regular basis.
02:40
When they were sick, we would collect specimens from them.
02:42
We would actually enlist them --
02:44
which we've done now -- to collect specimens from animals.
02:46
We give them these little pieces of filter paper.
02:48
When they sample from animals,
02:50
they collect the blood on the filter paper
02:52
and this allows us to identify yet-unknown viruses from exactly the right animals --
02:54
the ones that are actually being hunted.
02:58
(Video) Narrator: Deep in a remote region of Cameroon,
03:04
two hunters stalk their prey.
03:06
Their names are Patrice and Patee.
03:09
They're searching for bush meat;
03:11
forest animals they can kill to feed their families.
03:14
Patrice and Patee set out most days to go out hunting
03:18
in the forest around their homes.
03:20
They have a series of traps, of snares that they've set up
03:23
to catch wild pigs, snakes, monkeys,
03:25
rodents -- anything they can, really.
03:29
Patrice and Patee have been out for hours but found nothing.
03:33
The animals are simply gone.
03:39
We stop for a drink of water.
03:43
Then there is a rustle in the brush.
03:48
A group of hunters approach,
03:53
their packs loaded with wild game.
03:58
There's at least three viruses
04:02
that you know about, which are in this particular monkey.
04:04
Nathan Wolfe: This species, yeah. And there's many many more pathogens
04:07
that are present in these animals.
04:09
These individuals are at specific risk,
04:11
particularly if there's blood contact, they're at risk for transmission
04:14
and possibly infection with novel viruses.
04:17
Narrator: As the hunters display their kills, something surprising happens.
04:22
They show us filter paper they've used to collect the animals' blood.
04:25
The blood will be tested for zoonotic viruses,
04:29
part of a program Dr. Wolfe has spent years setting up.
04:32
NW: So this is from this animal right here,
04:35
Greater Spot-Nosed Guenon.
04:37
Every person who has one of those filter papers has at least,
04:39
at a minimum, been through our basic health education
04:41
about the risks associated with these activities,
04:44
which presumably, from our perspective,
04:47
gives them the ability to decrease their own risk,
04:49
and then obviously the risk to their families,
04:51
the village, the country, and the world.
04:54
NW: OK, before I continue, I think it's important to take just a moment
04:58
to talk about bush meat. Bush meat is the hunting of wild game.
05:01
OK? And you can consider all sorts of different bush meat.
05:04
I'm going to be talking about this.
05:06
When your children and grandchildren
05:08
sort of pose questions to you about this period of time,
05:10
one of the things they're gonna ask you,
05:12
is how it was they we allowed some of our closest living relatives,
05:14
some of the most valuable and endangered species
05:17
on our planet, to go extinct because we
05:19
weren't able to address some of the issues
05:22
of poverty in these parts of the world.
05:24
But in fact that's not the only question they're going to ask you about this.
05:26
They're also going to ask you the question
05:29
that when we knew that this was the way that HIV entered
05:31
into the human population,
05:33
and that other diseases had the potential to enter like this,
05:35
why did we let these behaviors continue?
05:37
Why did we not find some other solution to this?
05:39
They're going to say, in regions of profound
05:41
instability throughout the world,
05:44
where you have intense poverty, where populations are growing
05:46
and you don't have sustainable resources like this,
05:49
this is going to lead to food insecurity.
05:51
But they're also going to ask you probably a different question.
05:56
It's one that I think we all need to ask ourselves,
05:58
which is, why we thought the responsibility rested with this individual here.
06:00
Now this is the individual -- you can see just right up over his right shoulder --
06:04
this is the individual that hunted the monkey
06:07
from the last picture that I showed you.
06:09
OK, take a look at his shirt.
06:11
You know, take a look at his face.
06:13
Bush meat is one of the central crises,
06:16
which is occurring in our population right now,
06:19
in humanity, on this planet.
06:21
But it can't be the fault of somebody like this.
06:23
OK? And solving it cannot be his responsibility alone.
06:26
There's no easy solutions,
06:30
but what I'm saying to you is that we neglect this problem
06:32
at our own peril.
06:34
So, in 1998, along with my mentors
06:36
Don Burke and Colonel Mpoudi-Ngole,
06:39
we went to actually start this work
06:41
in Central Africa, to work with hunters
06:43
in this part of the world.
06:45
And my job -- at that time I was a post-doctoral fellow,
06:47
and I was really tasked with setting this up.
06:50
So I said to myself, "OK, great --
06:52
we're gonna collect all kinds of specimens. We're gonna go to all these
06:54
different locations. It's going to be wonderful."
06:56
You know, I looked at the map; I picked out 17 sites;
06:59
I figured, no problem.
07:01
(Laughter)
07:03
Needless to say, I was drastically wrong.
07:05
This is challenging work to do.
07:07
Fortunately, I had and continue to have
07:09
an absolutely wonderful team of colleagues and collaborators in my own team,
07:11
and that's the only way that this work can really occur.
07:14
We have a whole range of challenges about this work.
07:16
One of them is just obtaining trust
07:19
from individuals that we work with in the field.
07:21
The person you see on the right hand side is Paul DeLong-Minutu.
07:23
He's one of the best communicators that I've really ever dealt with.
07:27
When I arrived I didn't speak a word of French,
07:29
and I still seemed to understand what it was he was saying.
07:31
Paul worked for years
07:34
on the Cameroonian national radio and television,
07:36
and he spoke about health issues. He was a health correspondent.
07:38
So we figured we'd hire this person -- when we got there he could
07:41
be a great communicator.
07:43
When we would get to these rural villages, though, what we found out
07:45
is that no one had television,
07:47
so they wouldn't recognize his face.
07:49
But -- when he began to speak
07:52
they would actually recognize his voice from the radio.
07:55
And this was somebody who had incredible
07:57
potential to spread aspects of our message,
07:59
whether it be with regards to wildlife conservation
08:01
or health prevention.
08:04
Often we run into obstacles. This is us coming back from
08:07
one of these very rural sites,
08:09
with specimens from 200 individuals
08:11
that we needed to get back to the lab within 48 hours.
08:13
I like to show this shot -- this is
08:15
Ubald Tamoufe, who's the lead
08:17
investigator in our Cameroon site.
08:19
Ubald laughs at me when I show this photo
08:21
because of course you can't see his face.
08:23
But the reason I like to show the shot
08:25
is because you can see that he's about to solve this problem.
08:27
(Laughter)
08:30
Which -- which he did, which he did.
08:31
Just a few quick before and after shots.
08:34
This was our laboratory before.
08:36
This is what it looks like now.
08:39
Early on, in order to ship our specimens,
08:41
we had to have dry ice. To get dry ice we had to go
08:43
to the breweries -- beg, borrow, steal to get these folks to give it to us.
08:45
Now we have our own liquid nitrogen.
08:48
I like to call our laboratory the coldest place in Central Africa -- it might be.
08:51
And here's a shot of me, this is the before shot of me.
08:56
(Laughter)
09:00
No comment.
09:02
So what happened? So during the 10 years that we've been doing
09:04
this work, we actually surprised ourselves.
09:06
We made a number of discoveries.
09:09
And what we've found is that if you look in the right place,
09:12
you can actually monitor the flow
09:14
of these viruses into human populations.
09:16
That gave us a tremendous amount of hope.
09:18
What we've found is a whole range of new viruses in these individuals,
09:20
including new viruses in the same group
09:23
as HIV -- so, brand new retroviruses.
09:25
And let's face it, any new retrovirus in the
09:28
human population -- it's something we should be aware of.
09:30
It's something we should be following. It's not something
09:33
that we should be surprised by.
09:35
Needless to say in the past
09:37
these viruses entering into these rural communities
09:39
might very well have gone extinct.
09:41
That's no longer the case. Logging roads provide access to urban areas.
09:43
And critically, what happens in central Africa
09:47
doesn't stay in Central Africa.
09:51
So, once we discovered that it was really possible
09:54
that we could actually do this monitoring,
09:56
we decided to move this from research, to
09:58
really attempt to phase up to a global monitoring effort.
10:00
Through generous support and partnership
10:04
scientifically with Google.org and the Skoll Foundation,
10:06
we were able to start the Global Viral Forecasting Initiative
10:09
and begin work in four different sites
10:13
in Africa and Asia.
10:15
Needless to say, different populations from different parts of the world
10:18
have different sorts of contact.
10:20
So it's not just hunters in Central Africa.
10:22
It's also working in live animal markets --
10:25
these wet markets -- which is exactly the place where
10:27
SARS emerged in Asia.
10:29
But really, this is just the beginning from our perspective.
10:31
Our objective right now, in addition to
10:33
deploying to these sites and getting everything moving,
10:35
is to identify new partners
10:37
because we feel like this effort needs to be extended
10:39
to probably 20 or more sites throughout the world -- to viral hotspots --
10:42
because really the idea here is to cast an incredibly wide net
10:46
so that we can catch these things, ideally,
10:49
before they make it to blood banks,
10:51
sexual networks, airplanes. And that's really our objective.
10:53
There was a time not very long ago
10:57
when the discovery of unknown organisms
10:59
was something that held incredible awe for us.
11:01
It had potential to really change the way that we saw ourselves,
11:04
and thought about ourselves.
11:07
Many people, I think, on our planet right now
11:09
despair, and they think
11:11
we've reached a point where we've discovered most of the things.
11:14
I'm going tell you right now: please don't despair.
11:17
If an intelligent extra-terrestrial
11:20
was taxed with writing the encyclopedia of life on our planet,
11:22
27 out of 30 of these volumes
11:25
would be devoted to bacteria and virus,
11:27
with just a few of the volumes left
11:30
for plants, fungus and animals,
11:32
humans being a footnote;
11:34
interesting footnote but a footnote nonetheless.
11:37
This is honestly the most exciting period
11:40
ever for the study of unknown life forms on our planet.
11:43
The dominant things that exist here
11:47
we know almost nothing about.
11:49
And yet finally, we have the tools, which will allow us to actually explore that world
11:51
and understand them.
11:54
Thank you very much.
11:58
(Applause)
12:00

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Nathan Wolfe - Virus hunter
Armed with blood samples, high-tech tools and a small army of fieldworkers, Nathan Wolfe hopes to re-invent pandemic control -- and reveal hidden secrets of the planet's dominant lifeform: the virus.

Why you should listen

Using genetic sequencing, needle-haystack research, and dogged persistence (crucial to getting spoilage-susceptible samples through the jungle and to the lab), Nathan Wolfe has proven what was science-fiction conjecture only a few decades ago -- not only do viruses jump from animals to humans, but they do so all the time. Along the way Wolfe has discovered several new viruses, and is poised to discover many more.

Wolfe's research has turned the field of epidemiology on its head, and attracted interest from philanthropists at Google.org and the Skoll foundation. Better still, the research opens the door to preventing epidemics before they happen, sidelining them via early-warning systems and alleviating the poverty from which easy transmission emerges.

The original video is available on TED.com
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