Joy Wolfram: How nanoparticles could change the way we treat cancer
جوي ولفرام: كيف يمكن لجزيئات النانو أن تغير من الطريقة التي نعالج بها السرطان
Joy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic. Full bio
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back in April of this year.
من هذا العام
what are you talking about?"
you have to let me go.
with breast cancer.
researchers are committed
over 100 billion on cancer research
يزيد عن مائة مليار على أبحاث السرطان
in regards to patient survival,
بعلاج المريض وشفائه
of very aggressive cancers.
has not been working.
is to send out firefighters,
رجال إطفاء
are the cancer drugs.
without a fire truck --
never make it to the fire.
لم يتمكنوا من الوصول إلي تلك النيران
never make it to the tumor
للسرطان لا تتمكن من الوصول للورم
they're aiming for.
location, location, location.
بالمكان، المكان، المكان
to get to the right location.
لكي نتمكن من الوصول للمكان الصحيح
that nanoparticles are the fire trucks.
النانو هي ما تمثل سيارات الإطفاء
inside nanoparticles,
بداخل جزيئات النانو
can function as the carrier
to the heart of the tumor.
to be nano-sized?
types of nanoparticles
what it means to be nano-sized,
في حجم النانو
40,000 nanometers in diameter.
400 of our nanoparticles
جزيئات النانو التي لدينا
of a single hair strand.
to fight cancer and other diseases
السرطان وأمراض أخرى
to make a difference for patients,
إحداث فرق للمرضى
and grants to fund our research.
لتمويل أبحاثنا
manage to transport cancer drugs
نقل العلاج الخاص بالسرطان
are quickly washed out of the body
سريعاً خارج الجسم
to reach the tumor.
the cancer drugs.
washed out of the body
inside the tumor.
inside nanoparticles,
جزيئات النانو
to circulate in the blood,
the firefighters,
reaching the tumor.
do nanoparticles have?
تحتوي عليها جزيئات النانو؟
from getting destroyed inside the body.
من أن يُدمَر داخل الجسم
but sensitive drugs
by enzymes in the blood.
this nanoparticle protection,
جزيئات النانو
are these surface extensions
تلك الامتدادات السطحية
that grab on to the tumor
are circulating,
more time to do their job.
لأداء وظيفتها
that nanoparticles can have.
تتميز بها جزيئات النانو
nanoparticles for cancer
طبياً لعلاج السرطان
all over the world.
like Rebecca, who die.
challenges and limitations
الموافق عليها حالياً؟
filtration system,
بجسم الإنسان
and destroys foreign objects,
and also nanoparticles.
eat the nanoparticles,
جزيئات النانو
where the kidney is no longer a problem,
تمثل أي مشكلة
end up reaching the tumor.
to improve nanoparticles
جزيئات النانو
the immune cells in the liver.
that were already clinically approved
الموافقة عليها طبياً
could stop the immune cells
الخلايا المناعية
in one of our preclinical studies,
دراستنا التمهيدية
from internalizing the nanoparticles
أكل جزيئات النانو
to their goal, the tumor.
of blocking the liver.
are made in science
روابط غير متوقعة
for preventing nanoparticles
بالجسم نفسه
have a lot of nanoparticles
من جزيئات النانو
to label them as foreign.
على أنهم أجسام غريبة
can be found in the saliva,
يمكن أن توجد في اللعاب
in pancreatic juice.
for cancer drugs.
كعقاقير للسرطان
are less likely to eat
الخلايا المناعية في الكبد
a Trojan-horse-based concept
فكرة حصان طروادة
the biological nanoparticles
nature's own nanoparticles
الخاصة بالطبيعة نفسها
إنقاذ حياة المرضى
from being in the wrong location.
تكون في المكان الخطأ
nanoparticles in large quantities
من جزيئات النانو
an efficient method for doing this.
للقيام بذلك
of liquids from the body
من السوائل من الجسم
high-quality formulation
are not yet in clinical use,
طبيا حتى الآن
that requires teamwork
thanks to inspiration from patients.
الذي يأتي من المرضى
on these nanomedicines,
الادوية المصنعة بتكنولوجيا النانو
to healthy organs,
يلحق بأجهزة الجسم
had been available for Rebecca,
ABOUT THE SPEAKER
Joy Wolfram - NanotechnologistJoy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic.
Why you should listen
Dr. Joy Wolfram has designed many preclinical nanoparticles for treating cancer and other life-threatening diseases, and has authored more than 50 publications in the past five years. She is the director of the Nanomedicine and Extracellular Vesicles Laboratory at Mayo Clinic in Jacksonville, Florida, and holds affiliate faculty positions at the Houston Methodist Hospital, the University of North Florida and the Chinese Academy of Sciences. She is a board member and scientific advisor of several companies around the world with a cumulative customer base of more than 18 million.
Wolfram's mission is to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education, including serving as the chair of an education and outreach working group of the National Cancer Institute in the United States. She was included in the Amgen Scholars "ten to watch" list, which highlights the best and brightest up-and-comers in science and medicine across 42 countries.
A native of Finland, Wolfram was selected as one of 12 internationally accomplished Finns, alongside Nobel laureates. She was also listed on the Forbes "30 under 30" in healthcare in 2019. Additionally, she is part of the Global Young Academy, which represents 83 countries and is limited to 200 members who are selected based on scientific excellence and commitment to service.
Joy Wolfram | Speaker | TED.com