Joy Wolfram: How nanoparticles could change the way we treat cancer
Joy Wolfram: Hogyan módosíthatják a nanorészecskék a rák kezelését?
Joy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic. Full bio
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back in April of this year.
what are you talking about?"
you have to let me go.
with breast cancer.
researchers are committed
over 100 billion on cancer research
mint 100 milliárdot költött rákkutatásra
in regards to patient survival,
csak kevéssé javult,
of very aggressive cancers.
agresszív rákfajtákban.
has not been working.
is to send out firefighters,
are the cancer drugs.
without a fire truck --
never make it to the fire.
never make it to the tumor
sosem jut el a daganatig,
they're aiming for.
location, location, location.
a helytől és még egyszer a helytől függ.
to get to the right location.
hogy a megfelelő helyre jussunk.
that nanoparticles are the fire trucks.
a nanorészecskék a tűzoltóautók.
inside nanoparticles,
a nanorészecskékbe,
can function as the carrier
to the heart of the tumor.
a daganat kellős közepébe juttassuk.
to be nano-sized?
types of nanoparticles
what it means to be nano-sized,
40,000 nanometers in diameter.
400 of our nanoparticles
of a single hair strand.
akkor éri el a hajszálamét.
to fight cancer and other diseases
nanorészecske-labort vezetek
to make a difference for patients,
hogy javítsunk pácienseink életén,
and grants to fund our research.
adományoknak és juttatásoknak.
manage to transport cancer drugs
are quickly washed out of the body
a rákgyógyszerek a vesén keresztül
to reach the tumor.
the cancer drugs.
washed out of the body
inside the tumor.
inside nanoparticles,
to circulate in the blood,
the firefighters,
reaching the tumor.
do nanoparticles have?
from getting destroyed inside the body.
a testben való fölbomlástól.
but sensitive drugs
by enzymes in the blood.
könnyen fölbomolhatnak.
this nanoparticle protection,
are these surface extensions
a felületnövelő,
that grab on to the tumor
are circulating,
more time to do their job.
jut feladatuk elvégzésére.
that nanoparticles can have.
a nanorészecskék eszköztárából.
nanoparticles for cancer
nanorészecskénk van,
all over the world.
like Rebecca, who die.
pácienseink, akik elhunynak.
challenges and limitations
filtration system,
and destroys foreign objects,
a testünknek idegen anyagokat,
and also nanoparticles.
de a nanorészecskéket is.
eat the nanoparticles,
emésztik el a nanorészecskéket,
where the kidney is no longer a problem,
amikor már nem a vese okoz gondot,
a nanorészecskék
end up reaching the tumor.
to improve nanoparticles
the immune cells in the liver.
a máj immunsejtjeit.
that were already clinically approved
could stop the immune cells
a nanorészecskék elemésztésében.
in one of our preclinical studies,
tanulmányban váratlanul
from internalizing the nanoparticles
hogy bekebelezzék a nanorészecskéket.
to their goal, the tumor.
of blocking the liver.
are made in science
bukkannak föl a tudományban,
for preventing nanoparticles
a májban a nanorészecskék:
have a lot of nanoparticles
to label them as foreign.
idegen testként fogja föl őket.
can be found in the saliva,
megtalálhatók a nyálban,
in pancreatic juice.
és a hasnyálmirigy nedvében.
for cancer drugs.
használhatjuk őket.
are less likely to eat
a Trojan-horse-based concept
the biological nanoparticles
nature's own nanoparticles
és életmentésre, megakadályozva,
from being in the wrong location.
rossz helyre kerüljenek.
nanoparticles in large quantities
e nagy mennyiségű nanorészecskét,
an efficient method for doing this.
of liquids from the body
tudunk földolgozni,
kiváló minőségű
high-quality formulation
állíthatunk elő.
are not yet in clinical use,
nem alkalmazzák klinikailag,
that requires teamwork
thanks to inspiration from patients.
sarkallnak minket.
on these nanomedicines,
dolgozunk e nanogyógyszereken,
to healthy organs,
az egészséges szervekben okozott kárt,
had been available for Rebecca,
Rebecca rendelkezésére álltak volna,
ABOUT THE SPEAKER
Joy Wolfram - NanotechnologistJoy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic.
Why you should listen
Dr. Joy Wolfram has designed many preclinical nanoparticles for treating cancer and other life-threatening diseases, and has authored more than 50 publications in the past five years. She is the director of the Nanomedicine and Extracellular Vesicles Laboratory at Mayo Clinic in Jacksonville, Florida, and holds affiliate faculty positions at the Houston Methodist Hospital, the University of North Florida and the Chinese Academy of Sciences. She is a board member and scientific advisor of several companies around the world with a cumulative customer base of more than 18 million.
Wolfram's mission is to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education, including serving as the chair of an education and outreach working group of the National Cancer Institute in the United States. She was included in the Amgen Scholars "ten to watch" list, which highlights the best and brightest up-and-comers in science and medicine across 42 countries.
A native of Finland, Wolfram was selected as one of 12 internationally accomplished Finns, alongside Nobel laureates. She was also listed on the Forbes "30 under 30" in healthcare in 2019. Additionally, she is part of the Global Young Academy, which represents 83 countries and is limited to 200 members who are selected based on scientific excellence and commitment to service.
Joy Wolfram | Speaker | TED.com