Joy Wolfram: How nanoparticles could change the way we treat cancer
Joy Wolfram: Cómo las nanopartículas podrían cambiar el tratamiento del cáncer
Joy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic. Full bio
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back in April of this year.
en abril de este año,
what are you talking about?"
you have to let me go.
y debes dejarme ir.
with breast cancer.
contra un cáncer de mama.
researchers are committed
nos hemos comprometido
a los que les fallamos.
over 100 billion on cancer research
ha gastado más de 100 mil millones
in regards to patient survival,
ha tenido un progreso limitado,
of very aggressive cancers.
de cánceres muy agresivos.
hasta ahora no ha funcionado.
has not been working.
is to send out firefighters,
es enviar a los bomberos,
are the cancer drugs.
los medicamentos contra el cáncer.
without a fire truck --
de transporte, sin escaleras
never make it to the fire.
nunca llega al incendio.
never make it to the tumor
contra el cáncer nunca llegan al tumor
de transporte y de las herramientas
they're aiming for.
al que deben dirigirse.
location, location, location.
es lo más importante.
to get to the right location.
para que lleguen al lugar correcto.
that nanoparticles are the fire trucks.
son el camión de los bomberos.
inside nanoparticles,
el cáncer dentro de las nanopartículas,
can function as the carrier
to the heart of the tumor.
hasta el centro del tumor.
to be nano-sized?
tener un tamaño nano?
types of nanoparticles
de nanopartículas
what it means to be nano-sized,
lo que es el tamaño nano,
40,000 nanometers in diameter.
40 000 nanómetros de diámetro.
400 of our nanoparticles
400 nanopartículas
of a single hair strand.
to fight cancer and other diseases
y otras enfermedades
to make a difference for patients,
una diferencia en los pacientes,
and grants to fund our research.
donaciones y subvenciones
manage to transport cancer drugs
transportar los medicamentos
de herramientas.
are quickly washed out of the body
se eliminan rápidamente del cuerpo
to reach the tumor.
de llegar al tumor.
the cancer drugs.
washed out of the body
inside the tumor.
inside nanoparticles,
dentro de nanopartículas
to circulate in the blood,
para encontrar el tumor.
the firefighters,
es decir, los bomberos,
reaching the tumor.
do nanoparticles have?
tienen las nanopartículas?
from getting destroyed inside the body.
para que el cuerpo no los destruya.
but sensitive drugs
muy importantes, pero sensibles,
by enzymes in the blood.
por las enzimas de la sangre.
this nanoparticle protection,
la protección de las nanopartículas,
are these surface extensions
son unas extensiones,
that grab on to the tumor
con dedos que se aferran al tumor
are circulating,
las nanopartículas circulan
a las células cancerígenas,
more time to do their job.
para que realicen su trabajo.
that nanoparticles can have.
herramientas de las nanopartículas.
nanoparticles for cancer
contra el cáncer aprobadas clínicamente
all over the world.
en todo el mundo.
like Rebecca, who die.
como Rebecca, que mueren.
challenges and limitations
retos y las principales limitaciones
que ya están aprobadas?
filtration system,
de filtrado del cuerpo.
and destroys foreign objects,
los agentes extraños,
and also nanoparticles.
y también las nanopartículas.
eat the nanoparticles,
"comen" las nanopartículas,
where the kidney is no longer a problem,
que el riñón ya no es un problema,
o las nanopartículas,
end up reaching the tumor.
muy pocos llegan al tumor.
to improve nanoparticles
para mejorar las nanopartículas
the immune cells in the liver.
las células inmunitarias del hígado.
that were already clinically approved
que ya han sido aprobados clínicamente
could stop the immune cells
que las células inmunitarias
in one of our preclinical studies,
de nuestros estudios preclínicos,
la malaria, que existe desde hace 70 años,
from internalizing the nanoparticles
internalizaran las nanopartículas
to their goal, the tumor.
hasta su objetivo, el tumor.
of blocking the liver.
de cómo bloquean el hígado.
are made in science
conexiones inesperadas
for preventing nanoparticles
que las nanopartículas
nanopartículas del cuerpo.
have a lot of nanoparticles
tenemos muchas nanopartículas
to label them as foreign.
las reconozca como algo extraño.
can be found in the saliva,
se encuentran en la saliva,
in pancreatic juice.
en el jugo pancreático.
for cancer drugs.
para los medicamentos contra el cáncer.
are less likely to eat
que las células del hígado
a Trojan-horse-based concept
del caballo de Toya
the biological nanoparticles
nature's own nanoparticles
propias de la naturaleza
contra el cáncer,
secundarios y salvar vidas
from being in the wrong location.
el cáncer lleguen al lugar equivocado.
nanoparticles in large quantities
biológicas en grandes cantidades
an efficient method for doing this.
un método eficiente para lograrlo.
of liquids from the body
de líquidos del cuerpo
high-quality formulation
altamente concentrada, de gran calidad
are not yet in clinical use,
no se usan clínicamente,
llegue hasta el botiquín de la gente.
that requires teamwork
requiere trabajo de equipo
thanks to inspiration from patients.
que los pacientes nos dan.
on these nanomedicines,
en estos nanofármacos,
to healthy organs,
a los órganos sanos,
had been available for Rebecca,
acceder a estos tratamientos,
ABOUT THE SPEAKER
Joy Wolfram - NanotechnologistJoy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic.
Why you should listen
Dr. Joy Wolfram has designed many preclinical nanoparticles for treating cancer and other life-threatening diseases, and has authored more than 50 publications in the past five years. She is the director of the Nanomedicine and Extracellular Vesicles Laboratory at Mayo Clinic in Jacksonville, Florida, and holds affiliate faculty positions at the Houston Methodist Hospital, the University of North Florida and the Chinese Academy of Sciences. She is a board member and scientific advisor of several companies around the world with a cumulative customer base of more than 18 million.
Wolfram's mission is to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education, including serving as the chair of an education and outreach working group of the National Cancer Institute in the United States. She was included in the Amgen Scholars "ten to watch" list, which highlights the best and brightest up-and-comers in science and medicine across 42 countries.
A native of Finland, Wolfram was selected as one of 12 internationally accomplished Finns, alongside Nobel laureates. She was also listed on the Forbes "30 under 30" in healthcare in 2019. Additionally, she is part of the Global Young Academy, which represents 83 countries and is limited to 200 members who are selected based on scientific excellence and commitment to service.
Joy Wolfram | Speaker | TED.com