Joy Wolfram: How nanoparticles could change the way we treat cancer
조이 울프램(Joy Wolfram): 나노입자 기술이 항암 치료에 미칠 영향
Joy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic. Full bio
Double-click the English transcript below to play the video.
back in April of this year.
“나 레베카야.
what are you talking about?"
“레베카, 도대체 무슨 말이야?”
you have to let me go.
“조이, 친구로서 이제 나를 놓아줘.
with breast cancer.
researchers are committed
마지막이기를 바라며
over 100 billion on cancer research
천억 달러가 넘는 예산을
in regards to patient survival,
높아지지 못했습니다.
of very aggressive cancers.
암에 걸렸을 때 생존율이 낮습니다.
has not been working.
통하지 않기 때문입니다.
is to send out firefighters,
보내는 것과 같습니다.
비슷하기 때문입니다.
are the cancer drugs.
without a fire truck --
소방차도 없이 보냅니다.
never make it to the fire.
화재 현장에 도착하지 못합니다.
never make it to the tumor
종양에 도달하지 못합니다.
they're aiming for.
location, location, location.
종양이 있는 위치였습니다.
to get to the right location.
보낼 소방차가 필요합니다.
that nanoparticles are the fire trucks.
역할을 할 수 있습니다.
inside nanoparticles,
나노입자 내부에 실을 수 있고
can function as the carrier
to the heart of the tumor.
보낼 수 있습니다.
to be nano-sized?
types of nanoparticles
what it means to be nano-sized,
작은 크기를 실제로 보려면
한 올이 있습니다.
40,000 nanometers in diameter.
대략 4만 나노미터쯤 됩니다.
400 of our nanoparticles
of a single hair strand.
두께가 된다는 이야기입니다.
to fight cancer and other diseases
싸우기 위해 설립한 나노입자 연구소를
(Mayo Clinic)에서 이끌고 있습니다.
to make a difference for patients,
환자들을 치료합니다.
and grants to fund our research.
연구에 자금을 대주신 덕분입니다.
manage to transport cancer drugs
are quickly washed out of the body
콩팥을 거치며
빠져나가는 것과 비슷합니다.
to reach the tumor.
도달할 시간이 부족합니다.
the cancer drugs.
washed out of the body
inside the tumor.
inside nanoparticles,
약해지지 않을 것입니다.
to circulate in the blood,
순환을 지속하며
시간을 더 벌여줄 것입니다.
the firefighters,
reaching the tumor.
do nanoparticles have?
도구들을 지니고 있을까요?
from getting destroyed inside the body.
파괴되지 않게 보호할 수 있습니다.
but sensitive drugs
민감한 약물로
by enzymes in the blood.
this nanoparticle protection,
보호하지 않으면
are these surface extensions
표면 연장입니다.
that grab on to the tumor
작은 손처럼 종양을 잡고
are circulating,
more time to do their job.
있게 시간을 벌어줍니다.
that nanoparticles can have.
많은 도구를 지니고 있습니다.
nanoparticles for cancer
암세포를 치료하기 위해
임상적으로 입증되었습니다.
all over the world.
like Rebecca, who die.
사망한 환자들이 있습니다.
challenges and limitations
filtration system,
and destroys foreign objects,
찾아내어 파괴합니다.
and also nanoparticles.
그리고 나노입자 또한 파괴합니다.
eat the nanoparticles,
나노입자를 먹어 치워
where the kidney is no longer a problem,
더 이상 문제 되지 않음에도
end up reaching the tumor.
to improve nanoparticles
개선하기 위한 향후 전략은
the immune cells in the liver.
일시적으로 무력화하는 것입니다.
무력화할 수 있을까요?
that were already clinically approved
임상적으로 승인된
could stop the immune cells
나노입자를 못 먹게
보기 위해서였죠.
in one of our preclinical studies,
말라리아 치료제가
from internalizing the nanoparticles
내복화하는 것을 막아
to their goal, the tumor.
한다는 것을 발견했습니다.
of blocking the liver.
are made in science
for preventing nanoparticles
사용하는 것입니다.
have a lot of nanoparticles
많은 나노입자가
신체의 일부이기 때문에
to label them as foreign.
취급할 가능성이 작습니다.
can be found in the saliva,
췌액에서 발견할 수 있습니다.
in pancreatic juice.
for cancer drugs.
사용할 수 있습니다.
are less likely to eat
a Trojan-horse-based concept
비슷한 방법을 사용해
the biological nanoparticles
nature's own nanoparticles
막히는 것을 방지해
from being in the wrong location.
생명을 살리고자 합니다.
다음과 같습니다.
nanoparticles in large quantities
나노입자에 손상을 가하지 않고
an efficient method for doing this.
효율적인 방법을 개발했습니다.
of liquids from the body
high-quality formulation
만들 수 있습니다.
are not yet in clinical use,
임상에서 사용할 수 없습니다.
소요되기 때문입니다.
that requires teamwork
thanks to inspiration from patients.
통해 계속 연구합니다.
on these nanomedicines,
나노의학을 연구한다면
to healthy organs,
구할 수 있으리라 믿습니다.
had been available for Rebecca,
레베카에게 쓸 수 있었다면
ABOUT THE SPEAKER
Joy Wolfram - NanotechnologistJoy Wolfram leads a nanomedicine research lab with the goal of developing innovative nanoparticles that bring the next generation of treatments directly to the clinic.
Why you should listen
Dr. Joy Wolfram has designed many preclinical nanoparticles for treating cancer and other life-threatening diseases, and has authored more than 50 publications in the past five years. She is the director of the Nanomedicine and Extracellular Vesicles Laboratory at Mayo Clinic in Jacksonville, Florida, and holds affiliate faculty positions at the Houston Methodist Hospital, the University of North Florida and the Chinese Academy of Sciences. She is a board member and scientific advisor of several companies around the world with a cumulative customer base of more than 18 million.
Wolfram's mission is to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education, including serving as the chair of an education and outreach working group of the National Cancer Institute in the United States. She was included in the Amgen Scholars "ten to watch" list, which highlights the best and brightest up-and-comers in science and medicine across 42 countries.
A native of Finland, Wolfram was selected as one of 12 internationally accomplished Finns, alongside Nobel laureates. She was also listed on the Forbes "30 under 30" in healthcare in 2019. Additionally, she is part of the Global Young Academy, which represents 83 countries and is limited to 200 members who are selected based on scientific excellence and commitment to service.
Joy Wolfram | Speaker | TED.com