Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Rebecca Brachman: Nový druh léků, díky kterým můžeme předcházet rozvoji deprese a PTSD
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
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were made from, of all things,
antidepresiva byla vyrobena
které tu zbylo po 2. světové válce.
one in five soldiers develop depression,
že jeden z pěti vojáků má deprese
stresovou poruchu, nebo obojí.
that are at high risk for these diseases.
nehrozí jen vojákům.
cancer patients, aid workers, refugees --
pacientům s rakovinou,
nebo velkému životnímu stresu.
or major life stress.
these disorders are,
if they work at all,
discovered the first vaccine --
objevil první vakcínu -
a prophylactic for a disease,
proti nějaké nemoci,
to extend to psychiatric diseases.
nelze prevenci uplatnit.
accidentally discovered
kdy jsme já a moje kolegyně
který dokáže předcházet depresi a PTSD.
depression and PTSD.
whether they work in humans.
zda funguje u lidí.
psychopharmaceuticals
stress resilience,
že zvyšují odolnost vůči stresu,
that you've since recovered from.
ze které jste se již zotavili.
you missed a flight.
uletělo vám letadlo.
is the active biological process
aktivní biologický proces,
to bounce back after stress.
ze stresu zpátky do normálu.
and your immune system fights it off.
a váš imunitní systém proti tomu bojuje.
enough stressor,
such as depression.
jako je deprese.
of major depressive disorder
je vlastně vyvolána stresem.
against purely biological stressors,
proti čistě biologickým stresorům
like bullying and isolation.
jako šikana a odloučení.
kdy jsme myším po tři týdny
of stress hormones.
without a psychological component.
bez psychické složky.
of antidepressant treatment beforehand,
třítýdenní antidepresivní léčbu,
enhancer given a week before
podaná týden předem
the depressive behavior.
a drug has ever been shown
negativním účinkům stresu.
often lifelong, clinical diseases.
často celoživotní klinická onemocnění.
of substance abuse, homelessness,
návykových látek, bezdomovectví,
choroby a sebevražd.
is over three trillion dollars per year.
více než tři biliony dolarů ročně.
where we know someone is predictively
že je někdo předvídatelně
to extreme stress.
vystavení extrémnímu stresu.
going into an earthquake zone.
která jede do zóny zemětřesení.
k vakcíně proti tyfu dát
of a resilience enhancer
s posilovačem odolnosti.
by looters or worse,
nebo někdo ještě horší,
against developing depression or PTSD
proti rozvinutí deprese nebo PTSD.
from experiencing the stress,
her susceptibility to depression and PTSD,
k depresi a posttraumatickému stresu
her home, her family or even her life.
domov, rodinu, dokonce i její život.
the smallpox vaccine,
vakcínu proti neštovicím,
was widely available.
vakcína na tuberkulózu.
sensitive and creative and empathetic.
více citliví a kreativní a empatičtí.
by constitution and not biology.
stavba těla, ne biologie.
today about depression.
opened the door
jako Jennerův objev otevřel dveře
that followed after,
open the possibility of a whole new field:
otevírají dveře úplně novému oboru:
choose to do with it.
s tím rozhodneme udělat.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com