Rebecca Brachman: A new class of drug that could prevent depression and PTSD
麗貝卡‧布拉赫曼: 能預防憂鬱症和創傷後壓力症候群的全新藥物
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
火箭燃料所製成。
one in five soldiers develop depression,
有五分之一軍人罹患了憂鬱症,
that are at high risk for these diseases.
cancer patients, aid workers, refugees --
援助工作者和難民等 ––
或重大生活壓力下的人都可能罹患。
or major life stress.
these disorders are,
如果它們真的有效的話,
if they work at all,
discovered the first vaccine --
發現了首支疫苗 ––
a prophylactic for a disease,
to extend to psychiatric diseases.
可擴展運用到精神疾病。
accidentally discovered
當我和同事偶然發現
和創傷後壓力症的藥物。
depression and PTSD.
whether they work in humans.
psychopharmaceuticals
stress resilience,
恢復過來的時刻。
that you've since recovered from.
you missed a flight.
或是你錯過班機所引起。
is the active biological process
to bounce back after stress.
and your immune system fights it off.
免疫系統會對抗一樣。
enough stressor,
such as depression.
of major depressive disorder
against purely biological stressors,
單純的生物性壓力,
like bullying and isolation.
如欺凌與孤立。
of stress hormones.
without a psychological component.
心理因素的生物壓力。
of antidepressant treatment beforehand,
enhancer given a week before
復原力增強劑,
the depressive behavior.
a drug has ever been shown
often lifelong, clinical diseases.
通常是種慢性、終生的疾病。
of substance abuse, homelessness,
is over three trillion dollars per year.
每年全球就超過 3 兆美元。
where we know someone is predictively
to extreme stress.
going into an earthquake zone.
of a resilience enhancer
by looters or worse,
或遇到更糟的情況時,
against developing depression or PTSD
她經歷這種壓力,
from experiencing the stress,
her susceptibility to depression and PTSD,
和創傷後壓力症的發病機率,
her home, her family or even her life.
家人,甚至是她的生命。
the smallpox vaccine,
was widely available.
sensitive and creative and empathetic.
富創造性和同理心。
by constitution and not biology.
today about depression.
opened the door
that followed after,
open the possibility of a whole new field:
可能開啟了一個全新領域:
choose to do with it.
選擇要如何看待處理 。
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com