Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Rebeka Brakman (Rebecca Brachman): Nova vrsta lekova koja bi mogla da spreči depresiju i PTSP
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
pored svih mogućih opcija,
nakon Drugog svetskog rata.
one in five soldiers develop depression,
svaki peti vojnik razvije depresiju,
that are at high risk for these diseases.
pod visokim rizikom od ovih oboljenja.
cancer patients, aid workers, refugees --
lekari hitne pomoći,
humanitarci, izbeglice -
or major life stress.
ili velikom životnom stresu.
these disorders are,
if they work at all,
discovered the first vaccine --
otkrio prvu vakcinu -
a prophylactic for a disease,
za određenu bolest,
to extend to psychiatric diseases.
može proširiti na psihijatrijske bolesti.
accidentally discovered
depression and PTSD.
depresiju i PTSP.
whether they work in humans.
da li deluju na ljudima.
psychopharmaceuticals
stress resilience,
otpornost na stres,
pojačivačima otpornosti.
that you've since recovered from.
od koga ste se u međuvremenu oporavili.
you missed a flight.
ili ste zakasnili na avion.
is the active biological process
je aktivni biološki proces
to bounce back after stress.
da se oporavimo nakon stresa.
and your immune system fights it off.
i vaš imuni sistem se bori protiv toga.
koji je dovoljno značajan
enough stressor,
poremećaja kao što je depresija.
such as depression.
of major depressive disorder
videli kod miševa,
against purely biological stressors,
od čisto bioloških stresora
like bullying and isolation.
kao što je maltretiranje i izolovanost.
of stress hormones.
tokom tri nedelje.
without a psychological component.
bez psihološke komponente.
of antidepressant treatment beforehand,
tretman antidepresivima,
enhancer given a week before
data nedelju dana pre ovog događaja
the depressive behavior.
a drug has ever been shown
often lifelong, clinical diseases.
i često doživotne kliničke bolesti.
of substance abuse, homelessness,
od bolesti zavisnosti, beskućništva,
Alchajmerove bolesti i samoubistva.
is over three trillion dollars per year.
je preko tri biliona dolara godišnje.
where we know someone is predictively
u kome znamo da je neko pouzdano
to extreme stress.
ekstremnom stresu.
going into an earthquake zone.
koja ide u zonu zemljotresa.
of a resilience enhancer
ili injekciju pojačivača otpornosti
by looters or worse,
u nju ili se desi nešto još gore,
against developing depression or PTSD
od razvijanja depresije ili PTSP-a
from experiencing the stress,
da se oporavi od njega.
her susceptibility to depression and PTSD,
njenu podložnost depresiji i PTSP-u,
her home, her family or even her life.
posla, kuće, porodice ili čak života.
the smallpox vaccine,
otkrio vakcinu protiv velikih boginja,
was widely available.
nije postala široko dostupna.
sensitive and creative and empathetic.
činila ljude osetljivijim,
by constitution and not biology.
duševnim sklopom, a ne biologijom.
today about depression.
u vezi sa depresijom.
opened the door
koje su nakon toga usledile,
that followed after,
open the possibility of a whole new field:
otvaraju mogućnost potpuno novog polja:
choose to do with it.
odlučimo da uradimo sa njom.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com