Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Ребека Брахман: Нов клас лекарства, които могат да предотвратят депресия или ПТСР
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
били произведени не от какво да е,
от Втората световна война.
one in five soldiers develop depression,
една-пета от войниците развиват депресия
that are at high risk for these diseases.
на висок риск от тези заболявания.
cancer patients, aid workers, refugees --
болни, хуманитарни работници, бежанци -
or major life stress.
или сериозен стрес.
these disorders are,
на тези заболявания,
if they work at all,
ако изобщо работят,
discovered the first vaccine --
открива първата ваксина --
a prophylactic for a disease,
профилактика срещу едно заболяване,
предотвратява заболяванията.
повече от 200 години,
to extend to psychiatric diseases.
се простира до психиатричните заболявания.
accidentally discovered
не открихме случайно
depression and PTSD.
да предотвратят депресия и ПТСР.
whether they work in humans.
дали работят при хората.
psychopharmaceuticals
психофармацевтични препарати
stress resilience,
устойчивостта на стрес,
усилватели на устойчивостта.
that you've since recovered from.
от който вече сте се възстановили.
you missed a flight.
изпуснали сте полет.
is the active biological process
е активният биологичен процес,
to bounce back after stress.
да се изправим на крака след стреса.
and your immune system fights it off.
имунната ви система да пребори настинката.
достатъчно значителен стрес,
enough stressor,
such as depression.
като депресия.
of major depressive disorder
на тежко депресивно разстройство
което сме видяли досега при мишките,
against purely biological stressors,
да предпазват от чисто биологични стресори
like bullying and isolation.
като тормоза и изолацията.
в който давахме на мишките
of stress hormones.
в продължение на три седмици.
without a psychological component.
без психологически компонент.
of antidepressant treatment beforehand,
в продължение на три седмици преди това,
enhancer given a week before
устойчивостта дадена седмица предварително
the depressive behavior.
депресивното поведение.
a drug has ever been shown
когато лекарство доказано
отрицателните ефекти от стреса.
often lifelong, clinical diseases.
често доживотни, клинични разстройства.
of substance abuse, homelessness,
от злоупотреба с наркотици, бездомност,
Алцхаймер, самоубийство.
is over three trillion dollars per year.
е над три трилиона долара годишно.
where we know someone is predictively
в който знаем, че някой предсказуемо
to extreme stress.
на екстремни нива на стрес.
going into an earthquake zone.
който отива в земетръсна зона.
of a resilience enhancer
с усилвател на устойчивостта
by looters or worse,
от грабители или още по-лошо,
against developing depression or PTSD
да развие депресия или ПТСР
from experiencing the stress,
преживяване на стреса,
her susceptibility to depression and PTSD,
податливостта ѝ към депресия и ПТСР,
her home, her family or even her life.
да загуби работата,
the smallpox vaccine,
ваксината срещу едра шарка,
was widely available.
да стане широко достъпна.
sensitive and creative and empathetic.
чувствителни, изобретателни и емпатични.
by constitution and not biology.
а не на биология.
today about depression.
днес относно депресията.
opened the door
проправя път
that followed after,
open the possibility of a whole new field:
отварят възможността за цяла нова област:
choose to do with it.
ще изберем да направим с нея.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com