Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Rebecca Brachman: Een nieuwe categorie van medicijnen die depressie en PTSS zouden kunnen voorkomen
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
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were made from, of all things,
van nota bene raketbrandstof
na de Tweede Wereldoorlog.
one in five soldiers develop depression,
op de vijf soldaten depressie ontwikkelen
that are at high risk for these diseases.
een verhoogd risico op deze ziekten.
kankerpatiënten, hulpverleners,
cancer patients, aid workers, refugees --
aan trauma of enorme stress.
or major life stress.
these disorders are,
alledaags deze ziektes zijn,
if they work at all,
slechts de symptomen, als ze al werken.
discovered the first vaccine --
het eerste vaccin ontdekte --
a prophylactic for a disease,
preventieve behandeling voor een ziekte
to extend to psychiatric diseases.
voor psychiatrische stoornissen.
accidentally discovered
toevallig het eerste medicijn ontdekten
depression and PTSD.
zou kunnen voorkomen.
whether they work in humans.
of het ook bij mensen werkt.
psychopharmaceuticals
zijn geen antidepressiva.
stress resilience,
bij stress te verhogen,
veerkrachtversterkers noemen.
that you've since recovered from.
periode waarvan je hersteld bent --
you missed a flight.
of je miste een vliegtuig.
is the active biological process
is het actieve biologische proces
to bounce back after stress.
and your immune system fights it off.
een verkoudheid bestrijdt.
enough stressor,
such as depression.
psychische ziekte zoals depressie.
of major depressive disorder
kunnen beschermen
against purely biological stressors,
zoals stresshormonen,
like bullying and isolation.
stressfactoren als pesten en eenzaamheid.
hoge niveaus van stresshormonen gaven.
of stress hormones.
without a psychological component.
zonder psychologische component.
of antidepressant treatment beforehand,
antidepressiva toedienen,
enhancer given a week before
één dosis veerkrachtversterker toedienen,
the depressive behavior.
het depressieve gedrag.
a drug has ever been shown
often lifelong, clinical diseases.
vaak levenslange, klinische ziekten.
of substance abuse, homelessness,
op drugsmisbruik, dakloosheid,
van Alzheimer, zelfmoord --
is over three trillion dollars per year.
al meer dan drie biljoen dollar per jaar.
where we know someone is predictively
waarvan we kunnen voorspellen
op blootstelling aan extreme stress.
to extreme stress.
die een aardbevingsgebied betreedt.
going into an earthquake zone.
of a resilience enhancer
met een veerkrachtversterker
by looters or worse,
door overvallers of erger
against developing depression or PTSD
het ontwikkelen van depressie of PTSS
from experiencing the stress,
ervan kan herstellen.
her susceptibility to depression and PTSD,
voor depressie en PTSS sterk reduceren,
her home, her family or even her life.
huis, gezin of zelfs haar leven verliest.
the smallpox vaccine,
tegen pokken ontdekte,
was widely available.
tuberculose beschikbaar was.
de maatschappij geloofde
sensitive and creative and empathetic.
creatiever en meer empathisch maakte.
by constitution and not biology.
door constitutie en niet biologie.
today about depression.
tegenwoordig over depressie beweerd.
opened the door
ontdekking de deur opende
that followed after,
open the possibility of a whole new field:
de mogelijkheid van een nieuw gebied:
choose to do with it.
kiezen om ermee te doen.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com