Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Rebecca Brachman: Depresyon ve TSSB'yi önleyebilecek yeni bir ilaç sınıfı
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
roket yakıtlarından yapılırdı.
one in five soldiers develop depression,
çünkü beş askerden biri depresyon
ya da ikisini birden yaşıyor.
that are at high risk for these diseases.
olanlar, yalnızca askerler değil.
cancer patients, aid workers, refugees --
hastası, yardım görevlisi, mülteci --
or major life stress.
stresine maruz kalan herkes.
these disorders are,
ne kadar sıradan olursa olsun,
if they work at all,
discovered the first vaccine --
ilk aşıyı bulduğunda
a prophylactic for a disease,
korucuyu bulmamıştı,
to extend to psychiatric diseases.
uzanabileceğine inanılmıyordu.
accidentally discovered
ilk ilaçları keşfedene dek.
depression and PTSD.
whether they work in humans.
üzerinde çalışıyoruz.
psychopharmaceuticals
stress resilience,
işe yarıyorlar,
that you've since recovered from.
stresli bir zamanı düşünün.
you missed a flight.
belki uçağı kaçırmışsınızdır.
is the active biological process
kendimizi toparlamamızı sağlayan
to bounce back after stress.
and your immune system fights it off.
sisteminin onunla savaşması gibi.
bir stres etkeni karşısında
enough stressor,
such as depression.
bozuklukla sonuçlanabilir.
of major depressive disorder
depresif bozukluk durumuna,
against purely biological stressors,
saf biyolojik stres etkenlerine karşı,
psikolojik stres etkenlerine karşı
like bullying and isolation.
verdiğimiz bir örnek var burada.
of stress hormones.
without a psychological component.
bulundurmayan, biyolojik bir stres etkeni.
of antidepressant treatment beforehand,
antidepresan tedavisi verirsek
enhancer given a week before
tek doz direnç artırıcı,
the depressive behavior.
a drug has ever been shown
negatif etkilerini önlediği,
often lifelong, clinical diseases.
yaşam boyu süren klinik hastalıklardır.
of substance abuse, homelessness,
kalp hastalığı, Alzheimer, intihar
is over three trillion dollars per year.
bedeli, yılda üç trilyon dolar.
where we know someone is predictively
tahminen aşırı stresten ötürü
to extreme stress.
bir senaryo hayal edelim.
going into an earthquake zone.
bir deprem bölgesine gidiyor.
of a resilience enhancer
by looters or worse,
tutulduğunda veya daha kötü bir durumda,
against developing depression or PTSD
veya TSSB gelişimine karşı
from experiencing the stress,
her susceptibility to depression and PTSD,
çarpıcı şekilde azaltabiliyoruz
her home, her family or even her life.
hatta hayatını kaybetmemesini sağlıyoruz.
the smallpox vaccine,
aşısını bulduktan sonra,
yaygın biçimde mevcut olması,
was widely available.
sensitive and creative and empathetic.
ve anlayışlı yaptığına inanmasıydı.
by constitution and not biology.
anayasa sağlıyordu.
today about depression.
depresyon için de hala söyleniyor.
opened the door
kapıyı açtığı gibi,
that followed after,
open the possibility of a whole new field:
yeni bir alan olasılığını ortaya çıkardı:
choose to do with it.
ne yapmayı seçeceğine de bağlı.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com