TEDMED 2011
Bill Doyle: Treating cancer with electric fields
Bil Dojl (Bill Doyle): Lečenje raka električnim poljima
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Operacija, hemoterapija i zračenje su najpoznatije metode za lečenje raka. Bil Dojl na konferenciji TEDMED predstavlja novo rešenje, koje se naziva "Polja za terapiju tumora", pristup koji koristi elekrično polje koje interferira sa ćelijskom deobom. Iako je i dalje u povoju i odobrena je kao tretman za samo određene tipove raka, ova terapija nosi u sebi veliku prednost, a to je kvalitet života.
Bill Doyle - Engineer
With his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients. Full bio
With his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients. Full bio
Double-click the English transcript below to play the video.
00:15
Everybody in our society's life is touched by cancer --
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Rak utiče na život svih ljudi u našem društvu,
00:18
if not personally,
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ako ne baš lično,
00:20
then through a loved one, a family member,
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onda je deo priče naših voljenih, članova porodice,
00:23
colleague, friend.
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kolega, prijatelja.
00:25
And once our lives are touched by cancer,
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U momentu kada rak prodre u naše živote,
00:28
we quickly learn
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veoma brzo naučimo
00:30
that there are basically
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da postoje u osnovi
00:32
three weapons, or three tools, that are available
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tri tipa oružja, tri alata, kojima se
00:35
to fight the disease:
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borimo protiv ove bolesti:
00:38
surgery, radiation and chemotherapy.
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operacija, zračenje i hemoterapija.
00:41
And once we get involved
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U momentu kada postanemo deo
00:44
in the therapeutic decisions,
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donošenja odluka o terapiji
00:47
again either personally
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bilo baš lično
00:49
or with our loved ones and family members,
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ili preko naših voljenih i članova porodice,
00:52
we also very quickly learn
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veoma brzo shvatimo
00:55
the benefits, the trade-offs and the limitations
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prednosti, sporedne efekte i ograničenja
00:58
of these tools.
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ovih alata.
01:00
I'm very thankful to Jay and to Mark
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Veoma sam zahvalan Džeju i Marku
01:02
and the TEDMED team
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i ekipi TEDMED-a
01:04
for inviting me today
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na pozivu da vam danas
01:06
to describe a fourth tool, a new tool,
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opišem četvrto oruđe, novo oruđe,
01:09
that we call Tumor Treating Fields.
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koje nazivamo "Polja za tretiranje tumora".
01:12
Tumor Treating Fields
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Polja za tretiranje tumora
01:14
were invented by Dr. Yoram Palti,
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je izumeo dr Joram Palti,
01:17
professor emeritus at the Technion in Israel.
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počasni profesor na Tehnionu u Izraelu.
01:20
And they use low-intensity
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Oni koriste električna polja
01:22
electric fields
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slabe jačine
01:24
to fight cancer.
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u borbi protiv raka.
01:26
To understand how Tumor Treating Fields work,
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Da bismo razumeli kako ova polja rade,
01:29
we first need to understand
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moramo prvo shvatiti
01:31
what are electric fields.
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šta su električna polja.
01:33
Let me first address
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Prvo bih obrazložio
01:36
a few popular misconceptions.
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nekoliko opštih pogrešaka.
01:39
First of all, electric fields
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Pre svega, električna polja
01:41
are not an electric current
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nisu električna struja
01:43
that is coursing through the tissue.
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koja prolazi kroz tkivo.
01:46
Electric fields
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Električna polja
01:48
are not ionizing radiation,
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nisu jonizujuće zračenje
01:50
like X-rays or proton beams,
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kao što su X-zraci ili snopovi protona,
01:52
that bombard tissue
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koji bombarduju tkivo
01:54
to disrupt DNA.
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kako bi uništili DNK.
01:56
And electric fields
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Električna polja nisu
01:58
are not magnetism.
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ni magnetizam.
02:00
What electric fields are
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Električna polja
02:02
are a field of forces.
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su polje sila.
02:05
And these forces
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Ove sile ispoljavaju
02:07
act on, attract, bodies
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svoje dejstvo, deluju protiv tela
02:10
that have an electrical charge.
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koja imaju električnu maržu.
02:13
The best way to visualize an electric field
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Najbojli način da predstavite električno polje
02:15
is to think of gravity.
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je da zamislite gravitaciju.
02:17
Gravity is also a field of forces
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Gravitacija je takođe polje sila
02:20
that act on masses.
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koje deluje na masu.
02:22
We can all picture astronauts in space.
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Svi možemo da zamislimo astronaute u svemiru.
02:25
They float freely in three dimensions
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Oni slobodno plutaju u trodimenzionalnom prostoru
02:27
without any forces acting on them.
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bez ikakve sile koja deluje na njih.
02:29
But as that space shuttle
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Ali kada se svemirska letelica
02:32
returns to Earth,
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vrati na Zemlju,
02:34
and as the astronauts enter the Earth's gravitational field,
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i kada astronauti uđu u gravitacioni prostor Zemlje,
02:37
they begin to see the effects of gravity.
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oni počnu da osećaju uticaj gravitacije.
02:40
They begin to be attracted towards Earth.
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Zemlja počinje da ih privlači.
02:42
And as they land,
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U momentu prizemljenja
02:44
they're fully aligned in the gravitational field.
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su u potpunosti pod dejstvom gravitacionog polja.
02:46
We're, of course, all stuck in the Earth's gravitational field right now.
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Naravno, svi smo sada privezani gravitacionom silom za Zemlju.
02:49
That's why you're all in your chairs.
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Usled toga ste svi u svojim stolicama.
02:52
And that's why we have to use our muscle energy
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Zato moramo da koristimo energiju u mišićima
02:54
to stand up, to walk around
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kako bismo ustali, šetali okolo
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and to lift things.
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i kako bismo podigli stvari.
02:59
In cancer,
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U slučaju raka,
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cells rapidly divide
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ćelije se brzo umnožavaju
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and lead to uncontrolled tumor growth.
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što dovodi do nekontrolisanog rasta tumora.
03:06
We can think of a cell
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Ćeliju možemo zamisliti
03:09
from an electrical perspective
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sa stanovišta elekricizma
03:11
as if it's a mini space station.
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kao mini kosmičku stanicu.
03:14
And in that space station
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U toj stanici
03:16
we have the genetic material, the chromosomes,
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se nalazi genetički materijal, hromozomi,
03:19
within a nucleus.
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u jedru.
03:21
And out in the cytoplasmic soup
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A izvan toga, u citoplazmi
03:23
we have special proteins
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se nalaze posebni proteini,
03:25
that are required for cell division
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koji su neophodni kako bi se ćelije delile,
03:27
that float freely in this soup
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koji slobodno plutaju u tom buljonu
03:29
in three dimensions.
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u sve tri dimenzije.
03:31
Importantly, those special proteins
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Značajno je da su ti posebni proteini
03:34
are among the most highly charged objects
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među najelektrisanijim objektima
03:37
in our body.
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u našem telu.
03:39
As cell division begins
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Kada počne ćelijska deoba
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the nucleus disintegrates,
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dolazi do dezintegracije jedra,
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the chromosomes line up
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hromozomi se poređaju u ravan
03:45
in the middle of the cell
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na sredini ćelije
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and those special proteins
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i ovi posebni proteini
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undergo a three-dimensional sequence
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prolaze kroz seriju događaja
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whereby they attach
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pri čemu se prikače
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and they literally click into place end-on-end
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i bukvalno se uklope jedan za drugog
03:58
to form chains.
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kako bi formirali lanac.
04:00
These chains
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Ovi lanci se potom
04:02
then progress and attach
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izdužuju kako bi se prikačili
04:04
to the genetic material
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za genetički materijal
04:07
and pull the genetic material
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i razdvojili taj genetički materijal
04:09
from one cell into two cells.
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iz jedne u dve ćelije.
04:11
And this is exactly how
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Upravo na ovaj način
04:13
one cancer cell becomes two cancer cells,
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od jedne ćelije raka nastanu dve,
04:15
two cancer cells become four cancer cells,
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od dve ćelije raka nastanu četiri,
04:17
and we have ultimately
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i na kraju dođe do
04:19
uncontrolled tumor growth.
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nekontrolisanog rasta tumora.
04:22
Tumor Treating Fields
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Ova tehnologija
04:25
use externally placed transducers
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koristi spoljašnje transduktore
04:29
attached to a field generator
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koji su povezani za generatorom polja
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to create an artificial electric field
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kako bi stvorile veštačko električno polje
04:36
on that space station.
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u toj kosmičkoj stanici.
04:39
And when that cellular space station
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Kada je ćelijska kosmička stanica
04:42
is within the electric field,
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u okviru tog električnog polja
04:44
it acts on those highly charged proteins
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ona deluje na te visoko naelektrisane proteine
04:48
and aligns them.
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i poređa ih u red.
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And it prevents them from forming those chains,
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To ih sprečava da naprave te lance,
04:53
those mitotic spindles,
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to deobno vreteno,
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that are necessary to pull the genetic material
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koje je neophodno da bi se genetički materijal razdvojio
04:58
into the daughter cells.
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u dve ćerke ćelije.
05:00
What we see is that the cells will attempt to divide
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Uočili smo da ćelije pokušavaju da se podele
05:03
for several hours.
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po nekoliko sati.
05:05
And they will either enter into
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Ili će doći do
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this so-called cellular suicide,
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takozvanog samoubistva ćelije,
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programmed cell death,
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to je programirana ćelijska smrt,
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or they will form unhealthy daughter cells
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ili će od njih nastati nezdrave ćerke ćelije
05:15
and enter into apoptosis
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koje će ući u proces apoptoze
05:18
once they have divided.
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nakon ćelijske deobe.
05:20
And we can observe this.
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Možemo to uočiti.
05:22
What I'm going to show you next
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Ono što ću vam sada pokazati
05:24
are two in vitro experiments.
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su dva in vitro eksperimenta.
05:26
This is cultures, identical cultures,
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Ovo su kulture, identične kulture,
05:29
of cervical cancer cells.
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ćelija raka grlića materice.
05:31
And we've stained these cultures
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Obeležili smo ove ćelije
05:33
with a green florescent dye
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zelenom fluorescentnom bojom
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so that we can look at these proteins
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kako bismo mogli da posmatramo proteine
05:38
that form these chains.
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koji formiraju te lance.
05:40
The first clip shows
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Prvi snimak prikazuje
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a normal cell division
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normalnu ćelijsku deobu
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without the Tumor Treating Fields.
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bez primene "Polja za tretiranje tumora".
05:48
What we see
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Možemo uočiti
05:50
are, first of all, a very active culture,
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pre svega veoma aktivnu kulturu,
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a lot of divisions,
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mnogo deoba,
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and then very clear nuclei
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a potom veoma jasno definisana jedra
05:56
once the cells have separated.
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nakon razdvajanja ćelija.
05:58
And we can see them dividing throughout.
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Možemo uočiti ceo proces ćelijske deobe.
06:00
When we apply the fields --
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Kada primenimo polja,
06:02
again, in the identical time-scale
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ponovo, u istom vremenskom periodu
06:04
to the identical culture --
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na istovetnu kulturu,
06:06
you're going to see something different.
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videćete nešto drukčije.
06:08
The cells round up for division,
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Ćelije se spreme za deobu,
06:10
but they're very static in that position.
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ali su veoma statične u tom momentu.
06:13
We'll see two cells
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Možemo uočiti dve ćelije
06:15
in the upper part of the screen
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u pokušaju ćelijske deobe
06:20
attempting to divide.
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u gornjem delu ekrana.
06:22
The one within the circle manages.
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Ćeliji u okviru kruga to i uspeva.
06:24
But see how much of the protein
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Ali uočite koliko je proteina
06:26
is still throughout the nucleus,
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ostalo u jedru
06:28
even in the dividing cell.
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čak i u ćeliji koja se deli.
06:30
The one up there can't divide at all.
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Ova gore ne može da se podeli uopšte.
06:32
And then this bubbling, this membrane bubbling,
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Ovo bubrenje, bubrenje membrane,
06:35
is the hallmark
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je zaštitni znak
06:37
of apoptosis in this cell.
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apoptoze kod ćelija.
06:40
Formation of healthy mitotic spindles
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Formiranje funkcionalnog deobnog vretena
06:44
is necessary for division
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je neophodno za deobu
06:47
in all cell types.
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svih tipova ćelija.
06:49
We've applied Tumor Treating Fields
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Primenili smo "Polja za tretman tumora"
06:51
to over 20 different cancers in the lab,
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na oko 20 različitih tipova raka u laboratoriji,
06:54
and we see this effect
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i uočavamo isti efekat
06:56
in all of them.
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kod svih tipova.
06:59
Now importantly,
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Značajno je to
07:01
these Tumor Treating Fields have no effect
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da ova "Polja za tretman tumora" nemaju nikakav efekat
07:04
on normal undividing cells.
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na ćelije koje nisu u procesu deobe.
07:06
10 years ago,
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Dr. Palti je pre 10 godina
07:08
Dr. Palti founded a company called Novocure
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osnovao kompaniju "Novocure"
07:11
to develop his discovery
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kako bi svoje otkriće
07:14
into a practical therapy for patients.
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razvio do nivoa primene u lečenju pacijenata.
07:17
In that time, Novocure's developed two systems --
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U tu svrhu "Novocure" je razvio dva sistema -
07:21
one system for cancers in the head
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jedan za primenu u slučaju raka mozga,
07:24
and another system for cancers in the trunk of the body.
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i drugi za lečenja raka trupa tela.
07:27
The first cancer that we have focused on
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Prvi tip raka na koji smo se skoncentrisali
07:30
is the deadly brain cancer, GBM.
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je smrtonosni rak mozga, glioblastoma (GBM).
07:33
GBM affects about 10,000 people
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Od GBM-a oboli oko 10.000 osoba
07:36
in the U.S. each year.
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u SAD-u svake godine.
07:39
It's a death sentence.
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To je smrtna kazna.
07:41
The expected five year survival
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Verovatnoća za petogodišnje preživljanje
07:43
is less than five percent.
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je manja od 5 odsto.
07:45
And the typical patient
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Tipičan pacijent
07:47
with optimal therapy
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koji prima optimalnu terapiju
07:49
survives just a little over a year,
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će živeti malo duže od godinu dana,
07:52
and only about seven months
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i samo sedam meseci
07:54
from the time that the cancer is first treated
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od perioda kada je lečenje raka počelo
07:57
and then comes back and starts growing again.
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i kada dođe do relapsiranja tumora.
08:02
Novocure conducted
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"Novocure" je sproveo
08:04
its first phase three randomized trial
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prvu studiju treće faze uz nasumičan izbor pacijenata
08:06
in patients with recurrent GBM.
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sa relapsirajućim GBM-om.
08:08
So these are patients
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To su pacijenti koji
08:10
who had received surgery,
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su bili podvrgnuti operacijama,
08:14
high dose radiation to the head
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visokoj dozi zračenja glave
08:16
and first-line chemotherapy,
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i inicijalnoj hemoterapiji,
08:18
and that had failed and their tumors had grown back.
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sve to je bilo bezuspešno i tumor je relapsirao.
08:21
We divided the patients into two groups.
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Podelili smo pacijente u dve grupe.
08:24
The first group received second-line chemotherapy,
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Prva grupa pacijenata je tretirana sekundarnim režimom hemoterapije,
08:27
which is expected to double the life expectancy,
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koja bi trebalo da udvostruči period preživljavanja,
08:30
versus no treatment at all.
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u poređenju sa periodom preživljavanja bez ikakvog tretmana.
08:32
And then the second group
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Druga grupa pacijenata
08:34
received only Tumor Treating Field therapy.
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je bila podvrgnuta lečenju "Poljima za tretiranje tumora".
08:37
What we saw in that trial
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Ono što smo uočili u studiji je
08:39
is that that the life expectancies of both groups --
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da je period preživljavanja u slučaju obe grupe,
08:42
so the chemotherapy treated group
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dakle i onih koji su tretirani hemoterapijom,
08:44
and the Tumor Treating Field group --
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i onih koji su tretirani "Poljima za tretiranje tumora",
08:46
was the same.
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bio jednak.
08:48
But importantly,
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Međutim,
08:50
the Tumor Treating Field group
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ljudi koji su tretirani poljima koja leče tumor
08:53
suffered none of the side effects
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nisu patili ni od jedne kontraindikacije
08:56
typical of chemotherapy patients.
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koje su tipične za hemoterapiju.
08:59
They had no pain,
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Nisu bili u bolovima,
09:01
suffered none of the infections.
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nije došlo do infekcija.
09:04
They had no nausea, diarrhea,
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Nije bilo mučnine, dijareje,
09:07
constipation, fatigue
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zatvora, zamora
09:10
that would be expected.
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što bi bilo očekivano.
09:12
Based on this trial,
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Na osnovu ove studije,
09:14
in April of this year,
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iz aprila ove godine, Administracija
09:16
the FDA approved Tumor Treating Fields
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za hranu i lekove je odobrila upotrebu "Polja za tretiranje
09:19
for the treatment of patients
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tumora" za lečenje bolesnika
09:21
with recurrent GBM.
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koji pate od relapsirajuće forme GBM-a.
09:24
Importantly, it was the first time ever
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Ono što je važno je da je Administracija po prvi put
09:27
that the FDA included
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u svojim formularima za odobrenje
09:29
in their approval of an oncology treatment
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primene onkološkog tretmana
09:32
a quality of life claim.
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navela kvalitet života kao prednost.
09:36
So I'm going to show you now
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Pokazaću vam sada
09:39
one of the patients
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jednog pacijenta
09:41
from this trial.
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iz studije.
09:44
Robert Dill-Bundi
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Robert Dil-Bandi
09:46
is a famous Swiss cycling champion.
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je poznati švajcarski šampion u biciklizmu.
09:48
He won the gold medal in Moscow
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Osvojio je zlatnu medalju u Moskvi
09:50
in the 4,000 meter pursuit.
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u trci na 4.000 metara.
09:53
And five years ago,
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Pre pet godina,
09:56
Robert was diagnosed with GBM.
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Robertu je dijagnostikovan GBM.
09:59
He received the standard treatments.
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Lečen je standardnim protokolima.
10:01
He received surgery.
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Podvrgnut je operaciji.
10:04
He received high dose radiation to the head.
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Primio je visoku dozu zračenja glave.
10:07
And he received first-line chemotherapy.
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I dobio je inicijalnu hemoterapiju.
10:10
A year after this treatment --
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Godinu dana nakon tog tretmana,
10:12
in fact, this is his baseline MRI.
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ovo je ustvari njegov osnovni MR snimak.
10:15
You can see that the black regions
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Ovi crni delovi koje možete videti
10:18
in the upper right quadrant
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u gornjem desnom kvadrantu
10:20
are the areas where he had surgery.
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su delovi koji su bili podvrgnuti operaciji.
10:22
And a year after that treatment,
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Godinu dana nakon tretmana,
10:24
his tumor grew back with a vengeance.
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tumor se povratio u još agresivnijoj formi.
10:27
That cloudy white mass that you see
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Ova magličasta bela masa koju možete videti
10:30
is the recurrence of the tumor.
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je tumor koji se ponovo stvorio.
10:33
At this point, he was told by his doctors
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U tom momentu lekari su mu rekli
10:36
that he had about 3 months to live.
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da mu je ostalo još oko tri meseca života.
10:39
He entered our trial.
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Uključili smo ga u našu studiju.
10:41
And here we can see him getting the therapy.
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Ovde ga možemo videti u fazi lečenja.
10:44
First of all, these electrodes are noninvasive.
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Pre svega, ovo su neinvazivne elektrode.
10:47
They're attached to the skin
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Prikačene su za kožu
10:49
in the area of the tumor.
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u predelu tumora.
10:51
Here you can see
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Možete videti ovde
10:53
that a technician is placing them on there much like bandages.
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tehničara kako ih postavlja na sličan način kao i zavoj.
10:56
The patients learn to do this themselves
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Pacijenti nauče da sami ovo rade.
10:59
And then the patients
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Nakon toga pacijenti
11:02
can undergo all the activities of their daily life.
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mogu nastaviti sa uobičajenim dnevnim aktivnostima.
11:05
There's none of the tiredness.
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Ne dolazi do zamora.
11:07
There's none of what is called the "chemo head."
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Ne dolazi do sindroma nazvanog "hemo-glava".
11:10
There's no sensation.
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Ništa se ne oseća.
11:12
It doesn't interfere
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To ne interferira
11:14
with computers or electrical equipment.
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sa računarima ili električnom opremom.
11:17
And the therapy is delivered continuously
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Terapija se kontinuirano primenjuje
11:19
at home,
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kod kuće
11:21
without having to go into the hospital
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i nije potrebno odlaziti u bolnicu,
11:23
either periodically or continually.
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bilo periodično ili stalno.
11:26
These are Robert's MRIs,
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Ovo su Robertovi MR snimci,
11:29
again, under only TTField treatment.
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ponovo, pri isključivoj primeni terapije polja koja leče tumor.
11:32
This is a therapy that takes time to work.
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Neophodno je vreme da bi ova terapija delovala.
11:35
It's a medical device;
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To je medicinski uređaj,
11:37
it works when it's on.
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radi kada je uključen.
11:39
But what we can see is, by month six,
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Ali možemo da vidimo da već u šestom mesecu
11:41
the tumor has responded
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dolazi do delovanja na tumor
11:44
and it's begun to melt away.
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koji počinje lagano da nestaje.
11:47
It's still there.
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Još uvek je tamo.
11:49
By month 12,
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Ovde, u dvanaestom mesecu
11:51
we could argue whether
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možemo polemisati da li je
11:53
there's a little bit of material around the edges,
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preostalo nešto tkiva tumora oko samih ivica
11:55
but it's essentially completely gone.
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ali je u principu nestao potpuno.
11:58
It's now five years
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Prošlo je pet godina
12:00
since Robert's diagnosis,
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od uspostavljanja Robertove dijagnoze
12:02
and he's alive,
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i on je živ,
12:05
but importantly, he's healthy
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i što je važno, on je zdrav
12:07
and he's at work.
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i radi.
12:09
I'm going to let him, in this very short clip,
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U ovom kratkom filmu će vam on
12:11
describe his impressions of the therapy
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opisati svojim rečima
12:13
in his own words.
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utiske o terapiji.
12:15
(Video) Robert Dill-Bundi: My quality of life,
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(Snimak) Robert Dil-Bandi: Kvalitet mog života,
12:17
I rate what I have today
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ja ocenjujem ono što danas posedujem
12:19
a bit different than what most people would assume.
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malo drukčije u odnosu na ono što bi većina ljudi pretpostavila.
12:23
I am the happiest, the happiest person in the world.
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Ja sam najsrećnija, najsrećnija osoba na svetu.
12:28
And every single morning I appreciate life.
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Svakog jutra ja slavim život.
12:32
Every night I fall asleep very well,
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Svake noći lako zaspim,
12:35
and I am, I repeat,
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i ja sam, ponavljam,
12:38
the happiest man in the world,
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najsrećniji čovek na zemlji,
12:40
and I'm thankful I am alive.
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i zahvalan sam što sam živ.
12:45
BD: Novocure's also working on lung cancer
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BD: "Novocure" takođe radi na raku pluća,
12:48
as the second target.
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to je novi cilj.
12:50
We've run a phase two trial
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Sprovodimo drugu fazu studije
12:52
in Switzerland
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u Švajcarskoj
12:54
on, again, recurrent patients --
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i to ponovo na pacijentima sa relapsirajućim tumorom,
12:56
patients who have received standard therapy
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to su pacijenti koji su bili podrvgnuti standardnim tretmanima
12:59
and whose cancer has come back.
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a rak se ponovo javio.
13:02
I'm going to show you another clip
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Pokazaću vam još jedan snimak,
13:04
of a woman named Lydia.
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o ženi koja se zove Lidija.
13:06
Lydia's a 66 year-old farmer
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Lidija ima 66 godina i ona je poljoprivrednik
13:08
in Switzerland.
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u Švajcarskoj.
13:10
She was diagnosed with lung cancer
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Dijagnostifikovan joj je rak pluća
13:12
five years ago.
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pre pet godina.
13:14
She underwent four different regimes of chemotherapy
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U toku lečenja primila je četiri različita režima hemoterapije
13:17
over two years,
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u periodu od dve godine,
13:19
none of which had an effect.
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ni jedan od njih nije pokazao efekat.
13:21
Her cancer continued to grow.
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Njen rak je nastavljao da raste.
13:23
Three years ago,
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Pre tri godine
13:25
she entered the Novocure lung cancer trial.
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je pristupila studiji "Novocure"-a za lečenje raka pluća.
13:29
You can see, in her case,
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Možete vidti da u njenom slučaju
13:31
she's wearing her transducer arrays,
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ona nosi provodničke mreže,
13:33
one of the front of her chest, one on the back,
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jednu na grudima, jednu na leđima,
13:36
and then the second pair side-to-side over the liver.
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i još jedan par koji je postavljen jedan do drugog oko jetre.
13:39
You can see the Tumor Treating Field field generator,
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Možete uočiti i punjač "Polja za tretiranje tumora"
13:42
but importantly you can also see that she is living her life.
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ali još važnije možete videti da ona živi svoj život.
13:45
She is managing her farm.
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Ona održava svoje imanje.
13:47
She's interacting with her kids and her grand kids.
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Druži se sa svojom decom i unucima.
13:50
And when we talked to her,
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U razgovoru nam je rekla
13:53
she said that when she was undergoing chemotherapy,
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da je morala da ide u bolnicu svakog meseca kako bi primila svoju dozu,
13:55
she had to go to the hospital every month for her infusions.
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dok se lečila hemoterapijom.
13:58
Her whole family suffered
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Čitava njena porodica je patila
14:00
as her side effect profile came and went.
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dok je posmatrala nuz-pojave lečenja kako se javljaju i nestaju.
14:02
Now she can run
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Sada može da se bavi
14:04
all of the activities of her farm.
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svim delatnostima na svom imanju.
14:07
It's only the beginning.
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To je samo početak.
14:09
(Applause)
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(aplauz)
14:16
In the lab, we've observed tremendous synergies
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U laboratoriji smo uočili neverovatne sinergističke efekte
14:20
between chemotherapy and Tumor Treating Fields.
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hemoterapije i polja koja leče rak.
14:23
There's research underway now at Harvard Medical School
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U Školi medicine Harvarda je trenutno u toku istraživanje
14:26
to pick the optimum pairs
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koje iznalazi najbolje parove terapija
14:28
to maximize that benefit.
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koje bi pojačale prednosti tretmana.
14:30
We also believe that Tumor Treating Fields will work with radiation
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Takođe verujemo da će "Polja za tretiranje raka" davati dobre rezultate
14:33
and interrupt the self-repair mechanisms that we have.
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u sinergiji sa zračenjem pri onesposobljavanju mehanizama za reparaciju koje nosimo u sebi.
14:37
There's now a new research project underway
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Novi istraživački projekat, koji treba da
14:39
at the Karolinska in Sweden
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dokaže tu hipotezu, treba da počne
14:41
to prove that hypothesis.
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na institutu Karolinska u Švedskoj.
14:43
We have more trials planned
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Planirali smo još studija
14:45
for lung cancer,
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za izučavanje raka pluća,
14:47
pancreatic cancer, ovarian cancer
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raka gušterače, raka jajnika
14:49
and breast cancer.
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i raka dojki.
14:51
And I firmly believe
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Ja zaista verujem da će
14:53
that in the next 10 years
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u narednih deset godina
14:55
Tumor Treating Fields
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Polja za tretiranje tumora
14:57
will be a weapon available to doctors and patients
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biti dostupno oruđe za lekare i pacijente
15:00
for all of these most-difficult-to-treat solid tumors.
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za sve ove veoma teške forme tumora tvrdog tkiva.
15:06
I'm also very hopeful
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Takođe se nadam
15:08
that in the next decades,
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da ćemo u narednim decenijama
15:10
we will make big strides
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učiniti velike pomake
15:12
on reducing that death rate
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u smanjenju stope smrtnosti
15:15
that has been so challenging in this disease.
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koja je već toliko dugo istinski izazov kod ove bolesti.
15:18
Thank you.
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Hvala vam.
15:20
(Applause)
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(aplauz)
ABOUT THE SPEAKER
Bill Doyle - EngineerWith his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients.
Why you should listen
Bill Doyle is the executive chair of Novocure, a company commercializing a new therapeutic modality for solid tumors using low-intensity electric fields. Recently, Novocure received FDA approval for its first indication, recurrent Glioblastoma Multiforme (GBM), the most virulent form of brain cancer; it is now conducting additional clinical trials.
In 2002, Doyle co-founded medical device venture firm WFD Ventures, which provides financing and business-building expertise to medical device companies with the potential to make a major impact on patient care, working with entrepreneurs, doctors and scientists to improve medical outcomes and maximize the potential of their innovations.
A graduate of MIT, Doyle stablished the MIT FIRST Scholarship for FIRST Robotics Competition participants admitted to MIT.
Watch Jay Walker's onstage Q&A with Bill Doyle >>
Bill Doyle | Speaker | TED.com