ABOUT THE SPEAKER
Juan Enriquez - Futurist
Juan Enriquez thinks and writes about the profound changes that genomics and other life sciences will bring in business, technology, politics and society.

Why you should listen

A broad thinker who studies the intersections of these fields, Enriquez has a talent for bridging disciplines to build a coherent look ahead. He is the managing director of Excel Venture Management, a life sciences VC firm. He recently published (with Steve Gullans) Evolving Ourselves: How Unnatural Selection and Nonrandom Mutation Are Shaping Life on Earth. The book describes a world where humans increasingly shape their environment, themselves and other species.

Enriquez is a member of the board of Synthetic Genomics, which recently introduced the smallest synthetic living cell. Called “JCVI-syn 3.0,” it has 473 genes (about half the previous smallest cell). The organism would die if one of the genes is removed. In other words, this is the minimum genetic instruction set for a living organism.

More profile about the speaker
Juan Enriquez | Speaker | TED.com
TEDxSummit

Juan Enriquez: Will our kids be a different species?

Juan Enriquez: Hoće li naša djeca biti druga vrsta?

Filmed:
2,006,663 views

Kroz čovjekov razvoj, istovremeno su postojale višestruke verzije ljudi. Bismo li mi sada mogli biti na pola nadogradnje? Na TEDxSummit-u Juan Enriquez leti kroz vrijeme i prostor da bi nas doveo do sadašnjosti -- i pokazuje nam kako tehnologija otkriva dokaze koji govore da bi u toku mogla biti brza evolucija.
- Futurist
Juan Enriquez thinks and writes about the profound changes that genomics and other life sciences will bring in business, technology, politics and society. Full bio

Double-click the English transcript below to play the video.

00:16
All right. So, like all good storiespriče,
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U redu. Kao i svaka dobra priča,
00:18
this startspočinje a long, long time agoprije
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i ova počinje nekada davno
00:20
when there was basicallyu osnovi nothing.
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kada praktički nije bilo ničega.
00:22
So here is a completepotpun pictureslika of the universesvemir
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Ovdje je cjelokupna slika svemira
00:24
about 14-odd-neparan billionmilijardi yearsgodina agoprije.
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prije oko 14 milijardi godina.
00:28
All energyenergija is concentratedkoncentriran into a singlesingl pointtočka of energyenergija.
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Sva energija je koncentrirana u jednoj jedinoj točki energije.
00:31
For some reasonrazlog it explodeseksplodira,
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Iz nekog razloga eksplodira,
00:32
and you beginpočeti to get these things.
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i počinjete dobivati ovo.
00:35
So you're now about 14 billionmilijardi yearsgodina into this.
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Sada ste 14 milijardi godina u prošlosti.
00:37
And these things expandproširiti and expandproširiti and expandproširiti
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I to se širi i širi
00:39
into these giantgigantski galaxiesgalaksije,
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u ove ogromne galaksije,
00:41
and you get trillionstrilijuna of them.
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i dobijete ih na bilijune.
00:42
And withinunutar these galaxiesgalaksije
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A unutar ovih galaksija
00:44
you get these enormousogroman dustprah cloudsoblaci.
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dobijete ove ogromne oblake prašine.
00:47
And I want you to payplatiti particularposebno attentionpažnja
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Posebnu pažnju želim posvetiti
00:48
to the threetri little prongsParožak
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ovim trima šiljcima
00:50
in the centercentar of this pictureslika.
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u središtu ove slike.
00:52
If you take a close-upzatvori of those,
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Ako ih uvećate,
00:53
they look like this.
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izgledaju ovako.
00:55
And what you're looking at is columnsStupci of dustprah
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Gledate stupce prašine
00:58
where there's so much dustprah --
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gdje ima toliko prašine --
01:00
by the way, the scaleljestvica of this is a trillionbilijuna verticalvertikala milesmilja --
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usput, mjerilo je bilijun vertikalnih milja,
01:04
and what's happeningdogađa is there's so much dustprah,
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a ovdje ima toliko prašine,
01:07
it comesdolazi togetherzajedno and it fusesosigurači
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da se skuplja i sjedinjuje
01:09
and ignitesZapali a thermonucleartermonuklearna reactionreakcija.
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i dovodi do termonuklearne reakcije.
01:12
And so what you're watchinggledanje
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Upravo gledate
01:13
is the birthrođenja of starszvijezde.
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rođenje zvijezde.
01:15
These are starszvijezde beingbiće bornrođen out of here.
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Ove se zvijezde rađaju odavde.
01:17
When enoughdovoljno starszvijezde come out,
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Kada dovoljno zvijezda izađe,
01:19
they createstvoriti a galaxygalaksija.
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stvore galaksiju.
01:21
This one happensdogađa se to be a particularlynaročito importantvažno galaxygalaksija,
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Ovo je, naime, veoma važna galaksija,
01:24
because you are here.
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zato što ste vi ovdje.
01:27
(LaughterSmijeh)
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(Smijeh)
01:28
And as you take a close-upzatvori of this galaxygalaksija,
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I kako uvećavate snimku ove galaksije,
01:30
you find a relativelyrelativno normalnormalan,
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pronađete jednu relativno normalnu,
01:32
not particularlynaročito interestingzanimljiv starzvijezda.
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ne baš zanimljivu zvijezdu.
01:34
By the way, you're now about two-thirdsdvije trećine of the way into this storypriča.
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Usput, sad smo na dvije trećine ove priče.
01:38
So this starzvijezda doesn't even appearpojaviti
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Dakle, ova zvijezda se ni ne pojavi
01:40
untildo about two-thirdsdvije trećine of the way into this storypriča.
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do oko dvije trećine priče.
01:43
And then what happensdogađa se
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A onda
01:44
is there's enoughdovoljno dustprah left over
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je dovoljno prašine preostalo
01:46
that it doesn't ignitezapaliti into a starzvijezda,
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pa se ne upali u zvijezdu,
01:48
it becomespostaje a planetplaneta.
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već postane planet.
01:50
And this is about a little over fourčetiri billionmilijardi yearsgodina agoprije.
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A to se dogodilo prije malo više od 4 milijarde godina.
01:54
And soonuskoro thereafterNakon toga
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A uskoro nakon toga
01:56
there's enoughdovoljno materialmaterijal left over
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preostalo je dovoljno materijala
01:58
that you get a primordialpraiskonski soupjuha,
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da dobijete svemirsku juhu,
02:02
and that createsstvara life.
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iz koje nastaje život.
02:04
And life startspočinje to expandproširiti and expandproširiti and expandproširiti,
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I život se počne širiti i širiti,
02:08
untildo it goeside kaputpokvaren.
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dok ne ode k vragu.
02:10
(LaughterSmijeh)
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(Smijeh)
02:13
Now the really strangečudan thing
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Zbilja je neobično što
02:15
is life goeside kaputpokvaren, not oncejednom, not twicedvaput,
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život ne ode k vragu jednom, dvaput,
02:18
but fivepet timesputa.
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već pet puta.
02:20
So almostskoro all life on EarthZemlja
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Pa je skoro sav život na Zemlji
02:22
is wipedBrisanje out about fivepet timesputa.
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izbrisan oko pet puta.
02:24
And as you're thinkingmišljenje about that,
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I kako razmišljate o tome,
02:26
what happensdogađa se is you get more and more complexitysloženost,
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dobivate sve više kompleksnosti,
02:28
more and more stuffstvari
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sve više stvari
02:30
to buildizgraditi newnovi things with.
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za izgradnju novih stvari.
02:34
And we don't appearpojaviti
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A mi se ne pojavljujemo
02:35
untildo about 99.96 percentposto of the time into this storypriča,
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do oko 99.96% priče,
02:41
just to put ourselvessebe and our ancestorspreci in perspectiveperspektiva.
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tek da bismo to usporedili sa sobom i našim precima.
02:44
So withinunutar that contextkontekst, there's two theoriesteorije of the casespis
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Unutar tog konteksta postoje dvije teorije
02:48
as to why we're all here.
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zašto smo svi ovdje.
02:50
The first theoryteorija of the casespis
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Prva teorija
02:51
is that's all she wrotenapisao.
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je da je to gotova priča.
02:55
UnderPod that theoryteorija,
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Prema toj teoriji,
02:56
we are the be-allbiti sve and end-allkraj
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mi smo sve što postoji i kraj
02:58
of all creationstvaranje.
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svega što postoji.
03:00
And the reasonrazlog for trillionstrilijuna of galaxiesgalaksije,
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A razlog za postojanje bilijuna galaksija,
03:02
sextillionssextillions of planetsplaneti,
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trilijuna planeta,
03:04
is to createstvoriti something that looksizgled like that
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jest stvoriti nešto što izgleda ovako
03:09
and something that looksizgled like that.
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i nešto što izgleda onako.
03:13
And that's the purposesvrha of the universesvemir;
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I to je svrha svemira;
03:14
and then it flat-lineszaziva,
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kada umre,
03:16
it doesn't get any better.
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neće biti ništa bolje.
03:17
(LaughterSmijeh)
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(Smijeh)
03:21
The only questionpitanje you mightmoć want to askpitati yourselfsami is,
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Jedino pitanje koje biste si možda željeli postaviti
03:24
could that be just mildlyblago arrogantarogantni?
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jest: Nije li to pomalo arogantno?
03:29
And if it is --
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A ako jest --
03:31
and particularlynaročito givendan the factčinjenica that we camedošao very closeblizu to extinctionizumiranje.
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posebice zato što smo došli veoma blizu izumiranju.
03:37
There were only about 2,000 of our speciesvrsta left.
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U prošlosti je bilo preostalo samo 2.000 jedinki naše vrste.
03:40
A fewnekoliko more weeksTjedni withoutbez rainkiša,
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Još nekoliko tjedana bez kiše
03:42
we would have never seenvidio any of these.
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i nikada ne bismo vidjeli ništa od ovoga.
03:45
(LaughterSmijeh)
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(Smijeh)
03:52
(ApplausePljesak)
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(Pljesak)
03:56
So maybe you have to think about a seconddrugi theoryteorija
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Pa možda trebate razmisliti o drugoj teoriji
03:59
if the first one isn't good enoughdovoljno.
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ako prva nije dovoljno dobra.
04:02
SecondDrugi theoryteorija is: Could we upgradenadogradnja?
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Druga teorija je: Možemo li se nadograditi?
04:04
(LaughterSmijeh)
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(Smijeh)
04:07
Well, why would one askpitati a questionpitanje like that?
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Pa zašto bi netko tako nešto pitao?
04:10
Because there have been at leastnajmanje 29 upgradesnadogradnje so fardaleko
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Zato što je bilo barem 29 nadogradnji humanoida
04:13
of humanoidshumanoida.
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do sada.
04:15
So it turnsokreti out that we have upgradedažurirati na.
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Ispada da smo se već nadograđivali.
04:18
We'veMoramo upgradedažurirati na time and again and again.
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Nadograđivali smo se opet i opet iznova.
04:20
And it turnsokreti out that we keep discoveringotkrivanja upgradesnadogradnje.
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I ispada da i dalje otkrivamo nadogradnje.
04:22
We foundpronađeno this one last yeargodina.
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Ovu smo našli prošle godine.
04:25
We foundpronađeno anotherjoš one last monthmjesec.
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Još jednu smo našli prošli mjesec.
04:27
And as you're thinkingmišljenje about this,
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I dok razmišljate o tome,
04:29
you mightmoć alsotakođer askpitati the questionpitanje:
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mogli biste se zapitati:
04:32
So why a singlesingl humanljudski speciesvrsta?
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Pa zašto samo jedna ljudska vrsta?
04:35
Wouldn'tNe bi it be really oddneparan
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Ne bi li bilo stvarno čudno
04:36
if you wentotišao to AfricaAfrika and AsiaAsia and AntarcticaAntarktika
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da odete u Afriku, Aziju i na Antartiku
04:40
and foundpronađeno exactlytočno the sameisti birdptica --
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i nađete u potpunosti istu pticu --
04:43
particularlynaročito givendan that we co-existedživio zajedno at the sameisti time
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osobito ako uzmemo u obzir da smo postojali istovremeno
04:47
with at leastnajmanje eightosam other versionsverzije of humanoidhumanoida
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s barem osam drugih verzija humanoida
04:49
at the sameisti time on this planetplaneta?
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na ovom planetu?
04:52
So the normalnormalan statedržava of affairsposlovi
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Normalno stanje
04:54
is not to have just a HomoHomo sapienssapiensa;
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nije imati samo Homo sapiensa;
04:56
the normalnormalan statedržava of affairsposlovi
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normalno stanje je da
04:57
is to have variousraznovrstan versionsverzije of humansljudi walkinghodanje around.
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uokolo hodaju različite verzije ljudi.
05:01
And if that is the normalnormalan statedržava of affairsposlovi,
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A ako je to normalno stanje,
05:04
then you mightmoć askpitati yourselfsami,
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tada biste se mogli zapitati:
05:06
all right, so if we want to createstvoriti something elsedrugo,
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Ako želimo stvoriti nešto drugo,
05:08
how bigvelika does a mutationmutacija have to be?
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koliko velika mutacija treba biti?
05:11
Well SvanteSvante PaaboPabo has the answerodgovor.
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Svante Paabo ima odgovor.
05:14
The differencerazlika betweenizmeđu humansljudi and NeanderthalNeandertalac
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Razlika između ljudi i Neandertalaca
05:17
is 0.004 percentposto of genegen codekodirati.
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iznosi 0.004% genetskog koda.
05:20
That's how bigvelika the differencerazlika is
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Tolika je razlika
05:22
one speciesvrsta to anotherjoš.
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između te dvije vrste.
05:24
This explainsobjašnjava mostnajviše contemporarysuvremeni politicalpolitički debatesrasprave.
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To objašnjava najsuvremenije političke rasprave.
05:28
(LaughterSmijeh)
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(Smijeh)
05:30
But as you're thinkingmišljenje about this,
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Ali dok razmišljate o tome,
05:33
one of the interestingzanimljiv things
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jedna od zanimljivosti
05:35
is how smallmali these mutationsmutacije are and where they take placemjesto.
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jest koliko su te mutacije male i gdje se odvijaju.
05:38
DifferenceRazlika humanljudski/NeanderthalNeandertalac
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Razlika između čovjeka i Neandertalca
05:40
is spermsperme and testistestisa,
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je u spermi i testisima,
05:41
smellmiris and skinkoža.
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njuhu i koži.
05:43
And those are the specificspecifično genesgeni
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A to su konkretni geni
05:44
that differrazlikuju from one to the other.
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koji se razlikuju od jednog do drugog.
05:47
So very smallmali changespromjene can have a bigvelika impactudar.
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Dakle, veoma male promjene mogu imati veliki učinak.
05:50
And as you're thinkingmišljenje about this,
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A dok razmišljate o tome,
05:52
we're continuingnastavlja to mutatemutirati.
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nastavljamo mutirati.
05:54
So about 10,000 yearsgodina agoprije by the BlackCrna SeaMore,
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Prije oko 10.000 godina kraj Crnog mora
05:57
we had one mutationmutacija in one genegen
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dogodila se jedna mutacija u jednom genu
05:59
whichkoji led to blueplava eyesoči.
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koja je dovela do plavih očiju.
06:02
And this is continuingnastavlja and continuingnastavlja and continuingnastavlja.
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I to se nastavlja i nastavlja.
06:05
And as it continuesnastavlja,
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I kako se nastavlja,
06:07
one of the things that's going to happendogoditi se this yeargodina
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ove godine ćemo otkriti
06:09
is we're going to discoverotkriti the first 10,000 humanljudski genomesgenomi,
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prvih 10.000 ljudskih genoma,
06:12
because it's gottendobivši cheapjeftino enoughdovoljno to do the genegen sequencingsekvencioniranje.
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zato što je sekvenciranje gena postalo dovoljno jeftino.
06:15
And when we find these,
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A kada ih nađemo,
06:17
we maysvibanj find differencesRazlike.
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mogli bismo naći razlike.
06:19
And by the way, this is not a debatedebata that we're readyspreman for,
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Usput, to nije rasprava za koju smo spremni
06:22
because we have really misusedzloupotrebljavati the scienceznanost in this.
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zato što smo uistinu zloupotrijebili znanost u tome.
06:26
In the 1920s, we thought there were majorglavni differencesRazlike betweenizmeđu people.
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U 1920-ima, mislili smo da postoje važne razlike između ljudi.
06:29
That was partlydjelimično basedzasnovan on FrancisFranjo Galton'sGalton je work.
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To je dijelom bilo zbog rada Francisa Galtona.
06:33
He was Darwin'sDarwinova cousinrođak.
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Bio je Darwinov rođak.
06:35
But the U.S., the CarnegieCarnegie InstituteInstitut,
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Ali SAD, Carnegie institut,
06:38
StanfordStanford, AmericanAmerički NeurologicalNeurološki AssociationUdruga
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Stanford, American Neurological Association
06:40
tookuzeo this really fardaleko.
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su zbilja otišli daleko s tim.
06:42
That got exportedizvozi and was really misusedzloupotrebljavati.
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Ideja je izvezena i zbilja zloupotrebljena.
06:46
In factčinjenica, it led to some absolutelyapsolutno horrendousgrozan
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U biti, dovela je do nekih zbilja groznih
06:48
treatmentliječenje of humanljudski beingsbića.
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postupaka prema ljudskim bićima.
06:50
So sinceod the 1940s, we'veimamo been sayingizreka there are no differencesRazlike,
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Od 1940-ih govorimo da ne postoje razlike,
06:53
we're all identicalidentičan.
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da smo svi isti.
06:54
We're going to know at yeargodina endkraj if that is truepravi.
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Do kraja godine ćemo znati je li to istina.
06:58
And as we think about that,
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I dok razmišljamo o tome,
06:59
we're actuallyzapravo beginningpočetak to find things
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počeli smo zbilja pronalaziti stvari.
07:01
like, do you have an ACEAS genegen?
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3466
Na primjer, imate li ACE gen?
07:04
Why would that matterstvar?
161
408998
1978
Zašto bi to bilo važno?
07:06
Because nobody'sNitko nije ever climbedpopeo an 8,000-meter-metar peakvrh withoutbez oxygenkisik
162
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4038
Zato što su svi koji su se ikad popeli na vrh visok 8.000 metara bez kisika
07:10
that doesn't have an ACEAS genegen.
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imali ACE gen.
07:13
And if you want to get more specificspecifično,
164
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Ako želite ići u detalje,
07:15
how about a 577R genotypegenotip?
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3015
što kažete na 577R genotip?
07:18
Well it turnsokreti out that everysvaki malemuški OlympicOlimpijski powervlast atheleteathelete ever testedtestiran
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4700
Ispada da svaki muški olimpijski atletičar ikad testiran
07:23
carriesnosi at leastnajmanje one of these variantsvarijante.
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ima barem jednu od ovih varijanti.
07:26
If that is truepravi,
168
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1654
Ako je to točno,
07:28
it leadsvodi to some very complicatedsložen questionspitanja
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dolazi do nekih vrlo složenih pitanja
07:30
for the LondonLondon OlympicsOlimpijske igre.
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za londonske Olimpijske igre.
07:32
ThreeTri optionsopcije:
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Postoje tri mogućnosti.
07:33
Do you want the OlympicsOlimpijske igre to be a showcaseizlog
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Želite li da Olimpijske igre budu izlog
07:36
for really hardworkingRadin mutantsmutanti?
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za veoma marljive mutante?
07:39
(LaughterSmijeh)
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(Smijeh)
07:40
OptionMogućnost numberbroj two:
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Druga mogućnost:
07:43
Why don't we playigrati it like golfgolf or sailingjedrenje?
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Zašto se ne bismo natjecali kao u golfu ili jedrenju?
07:47
Because you have one and you don't have one,
177
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Zato što ga ti imaš, a on nema,
07:49
I'll give you a tenthdeseti of a seconddrugi headglava startpočetak.
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njemu ću dati desetinku sekunde prednosti.
07:53
VersionVerzija numberbroj threetri:
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1071
Verzija broj tri:
07:54
Because this is a naturallyprirodno occurringjavljaju genegen
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2069
Zato šo je to gen koji se prirodno javlja,
07:56
and you've got it and you didn't pickodabrati the right parentsroditelji,
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2782
ti ga imaš, a on nije odabrao prave roditelje,
07:59
you get the right to upgradenadogradnja.
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ima pravo na nadogradnju.
08:03
ThreeTri differentdrugačiji optionsopcije.
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Tri različite mogućnosti.
08:05
If these differencesRazlike are the differencerazlika
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1622
Ako su te razlike one razlike
08:06
betweenizmeđu an OlympicOlimpijski medalmedalja and a non-OlympicOlimpijski medalmedalja.
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koje odlučuju o osvajanju ili ne-osvajanju olimpijske medalje.
08:10
And it turnsokreti out that as we discoverotkriti these things,
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2834
I čini se da kako otkrivamo te stvari,
08:12
we humanljudski beingsbića really like to changepromijeniti
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3335
mi ljudska bića zbilja volimo mijenjati
08:16
how we look, how we actčin,
188
480388
1694
način na koji izgledamo, kako se ponašamo,
08:17
what our bodiestjelesa do.
189
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1594
što naša tijela rade.
08:19
And we had about 10.2 millionmilijuna plasticplastika surgeriesOperacija in the UnitedUjedinjeni StatesDržava,
190
483676
4374
Bilo je oko 10,2 milijuna plastičnih operacija u SAD-u,
08:23
exceptosim that with the technologiestehnologije that are comingdolazak onlinena liniji todaydanas,
191
488050
3317
samo što će se s tehnologijama koje će doći online ovih dana,
08:27
today'sdanas je correctionskorekcije, deletionsbrisanja,
192
491367
2701
današnje korekcije, brisanja,
08:29
augmentationsaugmentations and enhancementspoboljšanja
193
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povećanja i poboljšanja
08:31
are going to seemčiniti se like child'sdjeteta playigrati.
194
495987
2913
činiti kao dječja igra.
08:34
You alreadyveć saw the work by TonyTony AtalaAtala on TEDTED,
195
498900
3701
Već ste vidjeli rad Tonyja Atale na TED-u,
08:38
but this abilitysposobnost to startpočetak fillingpunjenje
196
502601
3567
ali ta sposobnost da se počnu puniti
08:42
things like inkjetinkjet cartridgespatrone with cellsStanice
197
506168
2933
stvari poput spremnika boje stanicama
08:45
are allowingomogućujući us to printotisak skinkoža, organsorgana
198
509101
4674
dopušta nam da tiskamo kožu, organe
08:49
and a wholečitav seriesniz of other bodytijelo partsdijelovi.
199
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2750
i cijeli niz drugih dijelova tijela.
08:52
And as these technologiestehnologije go forwardnaprijed,
200
516525
1884
A kako te tehnologije napreduju,
08:54
you keep seeingvidim this, you keep seeingvidim this, you keep seeingvidim things --
201
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3784
stalno viđate ovo, i ovo, viđate stvari --
08:58
2000, humanljudski genomegenom sequenceslijed --
202
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2774
2000., sekvenca humanog genoma --
09:00
and it seemsčini se like nothing'sNišta nije happeningdogađa,
203
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3782
i čini se da se ništa ne događa,
09:04
untildo it does.
204
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3112
sve dok se ne dogodi.
09:07
And we maysvibanj just be in some of these weeksTjedni.
205
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3524
A možda smo baš u nekom od tih tjedana.
09:11
And as you're thinkingmišljenje about
206
535385
1599
I dok razmišljate o
09:12
these two guys sequencingsekvencioniranje a humanljudski genomegenom in 2000
207
536984
3451
njih dvoje kako sekvenciraju ljudski genom u 2000.
09:16
and the PublicJavnim ProjectProjekt sequencingsekvencioniranje the humanljudski genomegenom in 2000,
208
540435
3553
i o Public Projectu koji također sekvencira ljudski genom u 2000.,
09:19
then you don't hearčuti a lot,
209
543988
3164
tada ne čujete mnogo,
09:23
untildo you hearčuti about an experimenteksperiment last yeargodina in ChinaKina,
210
547152
3984
dok ne čujete o jednom pokusu u Kini prošle godine.
09:27
where they take skinkoža cellsStanice from this mousemiš,
211
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4017
U tom pokusu su uzeli stanice kože ovog miša,
09:31
put fourčetiri chemicalskemikalije on it,
212
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1733
stavili četiri kemikalije na njih,
09:32
turnskretanje those skinkoža cellsStanice into stemstabljika cellsStanice,
213
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3566
pretvorili te stanice kože u matične stanice,
09:36
let the stemstabljika cellsStanice growrasti
214
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1465
dopustili matičnim stanicama da rastu
09:37
and createstvoriti a fullpuni copykopirati of that mousemiš.
215
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3087
i stvorili pravu kopiju tog miša.
09:40
That's a bigvelika dealdogovor.
216
565004
3247
To je velika stvar.
09:44
Because in essencesuština
217
568251
1016
Zato što to u osnovi
09:45
what it meanssredstva is you can take a cellćelija,
218
569267
2148
znači da možete uzeti stanicu,
09:47
whichkoji is a pluripotentpluripotentne stemstabljika cellćelija,
219
571415
2286
koja je pluripotentna matična stanica.
09:49
whichkoji is like a skierskijaš at the topvrh of a mountainplanina,
220
573701
2684
Ta stanica je poput skijaša na vrhu planine,
09:52
and those two skiersskijaši becomepostati two pluripotentpluripotentne stemstabljika cellsStanice,
221
576385
3817
a ova dva skijaša postanu dvije pluripotentne matične stanice,
09:56
fourčetiri, eightosam, 16,
222
580202
1782
četiri, osam, 16,
09:57
and then it getsdobiva so crowdedprometan
223
581984
1668
i tada nastaje takva gužva
09:59
after 16 divisionspodjela
224
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1800
nakon 16 dijeljenja
10:01
that those cellsStanice have to differentiaterazlikovati.
225
585452
2502
da se te stanice moraju diferencirati.
10:03
So they go down one sidestrana of the mountainplanina,
226
587954
1433
Dakle, spuste se niz jednu stranu planine,
10:05
they go down anotherjoš.
227
589387
1233
spuste se niz drugu.
10:06
And as they pickodabrati that,
228
590620
1534
I kako to odaberu,
10:08
these becomepostati bonekost,
229
592154
2250
postaju kosti,
10:10
and then they pickodabrati anotherjoš roadcesta and these becomepostati plateletsTrombociti,
230
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2932
a onda odaberu drugu stazu i postaju trombociti,
10:13
and these becomepostati macrophagesmakrofagi,
231
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2117
ove postaju makrofagi,
10:15
and these becomepostati T cellsStanice.
232
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1267
a ove postaju T limfociti.
10:16
But it's really hardteško, oncejednom you skiskijati down,
233
600720
1952
Ali zbilja je teško, jednom kad se spustite,
10:18
to get back up.
234
602672
1523
popeti se natrag gore.
10:20
UnlessOsim ako, of coursenaravno, if you have a skiskijati liftlift.
235
604195
5412
Osim ako, naravno, imate žičaru.
10:25
And what those fourčetiri chemicalskemikalije do
236
609607
2449
A te četiri kemikalije
10:27
is they take any cellćelija
237
612056
2069
uzmu bilo koju stanicu
10:30
and take it way back up the mountainplanina
238
614125
1932
i odnesu je natrag gore na planinu
10:31
so it can becomepostati any bodytijelo partdio.
239
616057
2033
pa može postati bilo koji dio tijela.
10:33
And as you think of that,
240
618090
1728
Kada razmislite,
10:35
what it meanssredstva is potentiallypotencijalno
241
619818
1980
to znači da potencijalno
10:37
you can rebuildobnoviti a fullpuni copykopirati
242
621798
2175
možete ponovno sagraditi pravu kopiju
10:39
of any organismorganizam
243
623973
1867
bilo kojeg organizma
10:41
out of any one of its cellsStanice.
244
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2586
iz bilo koje od njegovih stanica.
10:44
That turnsokreti out to be a bigvelika dealdogovor
245
628426
2531
To je velika stvar
10:46
because now you can take, not just mousemiš cellsStanice,
246
630957
2566
zato što možete uzeti, ne samo mišje stanice,
10:49
but you can humanljudski skinkoža cellsStanice
247
633523
2318
već ljudske stanice kože
10:51
and turnskretanje them into humanljudski stemstabljika cellsStanice.
248
635841
3650
i pretvoriti ih u ljudske matične stanice.
10:55
And then what they did in OctoberTravanj
249
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3198
A onda su u listopadu
10:58
is they tookuzeo skinkoža cellsStanice, turnedokrenut them into stemstabljika cellsStanice
250
642689
3400
uzeli stanice kože, pretvorili ih u matične stanice
11:01
and beganpočeo to turnskretanje them into liverjetra cellsStanice.
251
646089
3673
i počeli ih pretvarati u stanice jetre.
11:05
So in theoryteorija,
252
649762
1044
Dakle, teoretski,
11:06
you could growrasti any organorgulje from any one of your cellsStanice.
253
650806
5184
mogli biste uzgojiti bilo koji organ iz bilo koje od vaših stanica.
11:11
Here'sOvdje je a seconddrugi experimenteksperiment:
254
655990
1718
Evo drugog pokusa:
11:13
If you could photocopyfotokopija your bodytijelo,
255
657708
3133
Kada biste mogli fotokopirati svoje tijelo,
11:16
maybe you alsotakođer want to take your mindum.
256
660841
3052
možda biste također željeli uzeti i svoj um.
11:19
And one of the things you saw at TEDTED
257
663893
1565
A jedna od stvari koje ste vidjeli na TED-u
11:21
about a yeargodina and a halfpola agoprije
258
665458
1250
prije nekih godinu i pol
11:22
was this guy.
259
666708
1435
bio je ovaj tip.
11:24
And he gavedali a wonderfulpredivan technicaltehnička talk.
260
668143
2600
A on je održao prekrasan govor o tehnici.
11:26
He's a professorprofesor at MITMIT.
261
670743
1599
Profesor je na MIT-u.
11:28
But in essencesuština what he said
262
672342
1916
Ali, u suštini, rekao je da
11:30
is you can take retrovirusesretrovirusa,
263
674258
1700
možete uzeti retroviruse,
11:31
whichkoji get insideiznutra brainmozak cellsStanice of micemiševi.
264
675958
2800
koji dođu unutar mozgova miševa.
11:34
You can tagoznaka them with proteinsproteini
265
678758
2440
Možete ih označiti proteinima
11:37
that lightsvjetlo up when you lightsvjetlo them.
266
681198
2094
koji svijetle kada ih upalite.
11:39
And you can mapkarta the exacttočno pathwaysputevi
267
683292
3716
I možete mapirati točne puteve
11:42
when a mousemiš seesvidi, feelsosjeća, touchesdotakne,
268
687008
3483
kada miš vidi, osjeća, dodiruje,
11:46
rememberspamti, lovesvoli.
269
690491
2183
pamti, voli.
11:48
And then you can take a fibervlakno opticoptički cablekabel
270
692674
2373
A onda možete uzeti kabel s optičkim vlaknima
11:50
and lightsvjetlo up some of the sameisti things.
271
695047
3819
i upaliti neke od njih.
11:54
And by the way, as you do this,
272
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1832
A to što radite,
11:56
you can imageslika it in two colorsboje,
273
700698
2017
možete prikazati u dvije boje,
11:58
whichkoji meanssredstva you can downloadpreuzimanje datoteka this informationinformacija
274
702715
2399
što znači da možete downloadati tu informaciju
12:01
as binarybinarni codekodirati directlydirektno into a computerračunalo.
275
705114
4740
kao binarni kod izravno na kompjuter.
12:05
So what's the bottomdno linecrta on that?
276
709854
2473
Koja je poanta toga?
12:08
Well it's not completelypotpuno inconceivablenezamislivo
277
712327
2200
Pa, nije u potpunosti nezamislivo
12:10
that somedayjednog dana you'llvi ćete be ableu stanju to downloadpreuzimanje datoteka your ownvlastiti memoriessjećanja,
278
714527
4495
da ćete jednog dana moći downloadati vlastita sjećanja,
12:14
maybe into a newnovi bodytijelo.
279
719022
2387
možda u neko novo tijelo.
12:17
And maybe you can uploadUčitaj other people'snarodno memoriessjećanja as well.
280
721409
5085
A možda ćete moći i uploadati i sjećanja drugih ljudi.
12:22
And this mightmoć have just one or two
281
726494
2514
I to bi moglo imati samo jednu ili dvije
12:24
smallmali ethicaletički, politicalpolitički, moralmoralan implicationsimplikacije.
282
729008
3520
male etičke, političke, moralne implikacije.
12:28
(LaughterSmijeh)
283
732528
1531
(Smijeh)
12:29
Just a thought.
284
734059
2991
To je samo zamisao.
12:32
Here'sOvdje je the kindljubazan of questionspitanja
285
737050
1528
Evo vrste pitanja
12:34
that are becomingpostaje interestingzanimljiv questionspitanja
286
738578
1980
koja postaju zanimljivima
12:36
for philosophersfilozofi, for governingkojima se uređuje people,
287
740558
2484
za filozofe, ljude na vlasti,
12:38
for economistsekonomisti, for scientistsznanstvenici.
288
743042
3366
za ekonomiste, za znanstvenike.
12:42
Because these technologiestehnologije are movingkreće really quicklybrzo.
289
746408
3284
Jer, te tehnologije napreduju veoma brzo.
12:45
And as you think about it,
290
749692
1500
I dok razmišljate o tome,
12:47
let me closeblizu with an exampleprimjer of the brainmozak.
291
751192
3082
dopustite da dovršim jednim primjerom mozga.
12:50
The first placemjesto where you would expectočekivati
292
754274
1683
Prvo mjesto na kojem biste očekivali
12:51
to see enormousogroman evolutionaryevolucioni pressurepritisak todaydanas,
293
755957
3051
vidjeti ogromni evolucijski pritisak danas,
12:54
bothoba because of the inputsulazi,
294
759008
2265
i zbog inputa,
12:57
whichkoji are becomingpostaje massivemasivan,
295
761273
1552
koji postaju obilni,
12:58
and because of the plasticityplastičnost of the organorgulje,
296
762825
1782
i zbog plastičnosti tog organa,
13:00
is the brainmozak.
297
764607
2534
jest mozak.
13:03
Do we have any evidencedokaz that that is happeningdogađa?
298
767141
3318
Imamo li ikakve dokaze da se to događa?
13:06
Well let's take a look at something like autismautizam incidenceučestalost perpo thousandtisuću.
299
770459
4731
Pogledajmo na pojavu autizma na 1.000 ljudi.
13:11
Here'sOvdje je what it looksizgled like in 2000.
300
775190
2502
Evo kako je to izgledalo 2000.
13:13
Here'sOvdje je what it looksizgled like in 2002,
301
777692
2082
Ovako je izgledalo 2002.,
13:15
2006, 2008.
302
779774
4618
2006., 2008.
13:20
Here'sOvdje je the increasepovećati in lessmanje than a decadedesetljeće.
303
784392
4082
Eto povećanja u periodu manjem od jednog desetljeća.
13:24
And we still don't know why this is happeningdogađa.
304
788474
4417
I još ne znamo zašto se to događa.
13:28
What we do know is, potentiallypotencijalno,
305
792891
2485
Ono što znamo jest da, vjerojatno,
13:31
the brainmozak is reactingreakcijom in
306
795376
2032
mozak reagira na
13:33
a hyperactivehiperaktivna, hyper-plastichiper-plastika way,
307
797408
2134
hiperaktivan, hiper-plastičan način,
13:35
and creatingstvaranje individualspojedinci that are like this.
308
799542
2950
i stvara pojedince koji su ovakvi.
13:38
And this is only one of the conditionsUvjeti that's out there.
309
802492
2757
A to je samo jedan od uvjeta koji postoje.
13:41
You've alsotakođer got people with who are extraordinarilyizvanredno smartpametan,
310
805249
3540
Postoje i ljudi koji su natprirodno pametni,
13:44
people who can rememberzapamtiti everything they'vešto ga do seenvidio in theirnjihov livesživot,
311
808789
2397
ljude koji se sjećaju svega što su u životu vidjeli,
13:47
people who'vekoji su got synesthesiaSinestezija,
312
811186
1385
ljude koji imaju sinesteziju,
13:48
people who'vekoji su got schizophreniashizofrenija.
313
812571
1331
one koji imaju shizofreniju.
13:49
You've got all kindsvrste of stuffstvari going on out there,
314
813902
2534
Mnogo se toga tu događa,
13:52
and we still don't understandrazumjeti
315
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1218
a još uvijek ne razumijemo
13:53
how and why this is happeningdogađa.
316
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2233
kako i zašto.
13:55
But one questionpitanje you mightmoć want to askpitati is,
317
819887
2682
No, jedno pitanje koje biste možda željeli postaviti jest:
13:58
are we seeingvidim a rapidbrz evolutionevolucija of the brainmozak
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822569
2628
Vidimo li naglu evoluciju mozga
14:01
and of how we processpostupak datapodaci?
319
825197
1825
i načina na koji obrađujemo podatke?
14:02
Because when you think of how much data'sData je comingdolazak into our brainsmozak,
320
827022
3063
Kada razmislite o tome koliko podataka dolazi u naš mozak,
14:05
we're tryingtežak to take in as much datapodaci in a day
321
830085
3484
pokušavamo u jednom danu usvojiti toliko podataka
14:09
as people used to take in in a lifetimedoživotno.
322
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2551
koliko su ljudi usvajali tijekom cijelog života.
14:12
And as you're thinkingmišljenje about this,
323
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I dok razmišljate o tome,
14:14
there's fourčetiri theoriesteorije as to why this mightmoć be going on,
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postoje četiri teorije o tome zašto bi se to moglo događati,
14:16
plusplus a wholečitav seriesniz of othersdrugi.
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uz cijeli niz drugih.
14:18
I don't have a good answerodgovor.
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Ja nemam dobar odgovor.
14:19
There really needspotrebe to be more researchistraživanje on this.
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Zbilja bi trebalo biti više istraživanja o tome.
14:23
One optionopcija is the fastbrzo foodhrana fetishfetiš.
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Jedna mogućnost je fetiš brze prehrane.
14:25
There's beginningpočetak to be some evidencedokaz
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Počeli su se javljati dokazi da su
14:28
that obesitygojaznost and dietdijeta
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pretilost i prehrana
14:30
have something to do
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nekako povezani
14:32
with genegen modificationsizmjene,
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s modifikacijom gena,
14:33
whichkoji maysvibanj or maysvibanj not have an impactudar
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što može, ali ne mora imati utjecaja
14:36
on how the brainmozak of an infantdječji worksdjela.
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na način na koji mozak novorođenčeta radi.
14:39
A seconddrugi optionopcija is the sexyseksi geekštreber optionopcija.
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Druga mogućnost jest ona sexy štrebera.
14:43
These conditionsUvjeti are highlyvisoko rarerijedak.
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Ti uvjeti su zbilja rijetki.
14:47
(LaughterSmijeh)
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(Smijeh)
14:51
(ApplausePljesak)
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(Pljesak)
14:56
But what's beginningpočetak to happendogoditi se
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Počelo se događati da,
14:57
is because these geeksgeeks are all gettinguzimajući togetherzajedno,
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zato što se ti štreberi okupljaju,
15:00
because they are highlyvisoko qualifiedkvalificirani for computerračunalo programmingprogramiranje
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zato što su visoko kvalificirani za programiranje kompjutera
15:03
and it is highlyvisoko remuneratedplaćeni,
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što je veoma isplativo,
15:05
as well as other very detail-orienteddetalja taskszadaci,
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kao i drugi poslovi orijentirani na detalje,
15:08
that they are concentratingkoncentriraju geographicallygeografski
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da su geografski koncentrirani
15:11
and findingnalaz like-mindedistomišljenika matesmates.
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i pronalaze partnere sličnih svjetonazora.
15:14
So this is the assortativeassortative matingparenje hypothesishipoteza
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To je hipoteza selektivnog križanja
15:17
of these genesgeni reinforcingjačanje one anotherjoš
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tih gena koji pojačavaju jedan drugog
15:20
in these structuresstrukture.
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u tim strukturama.
15:22
The thirdtreći, is this too much informationinformacija?
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Treće, je li to previše informacija?
15:25
We're tryingtežak to processpostupak so much stuffstvari
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Pokušavamo obraditi toliko toga
15:27
that some people get synestheticsynesthetic
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da neki ljudi razviju sinesteziju
15:29
and just have hugeogroman pipescijevi that rememberzapamtiti everything.
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i imaju ogromne cijevi koje pamte sve.
15:32
Other people get hyper-sensitivehiper-sjetilni to the amountiznos of informationinformacija.
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Drugi ljudi postaju hiper-osjetljivi na količinu informacija.
15:34
Other people reactreagirati with variousraznovrstan psychologicalpsihološki conditionsUvjeti
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Drugi reagiraju različitim psihološkim stanjima
15:38
or reactionsreakcije to this informationinformacija.
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ili reakcijama na te informacije.
15:40
Or maybe it's chemicalskemikalije.
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Ili su možda kemikalije u pitanju.
15:43
But when you see an increasepovećati
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Ali kada vidite porast
15:44
of that ordernarudžba of magnitudeveličina in a conditionstanje,
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tih razmjera kod nekog stanja,
15:47
eitherili you're not measuringmjerenje it right
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ili ga ne mjerite kako treba
15:48
or there's something going on very quicklybrzo,
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ili se nešto događa veoma brzo,
15:51
and it maysvibanj be evolutionevolucija in realstvaran time.
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a mogla bi to biti evolucija u stvarnom vremenu.
15:55
Here'sOvdje je the bottomdno linecrta.
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Evo poante.
15:57
What I think we are doing
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Mislim da mi
15:59
is we're transitioningPrelaženje as a speciesvrsta.
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kao vrsta prelazimo u neko novo stanje.
16:01
And I didn't think this when SteveSteve GullansGullans and I startedpočeo writingpisanje togetherzajedno.
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A nisam to mislio kad smo Steve Gullans i ja počeli zajedno pisati.
16:07
I think we're transitioningPrelaženje into HomoHomo evolutisevolutis
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Mislim da prelazimo u Homo evolutisa
16:09
that, for better or worsegore,
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koji, bilo to dobro ili loše,
16:11
is not just a hominidhominida that's conscioussvjestan of his or her environmentokolina,
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nije samo hominid svjestan svoje okoline,
16:15
it's a hominidhominida that's beginningpočetak to directlydirektno and deliberatelynamjerno
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već hominid koji će početi izravno i namjerno
16:18
controlkontrolirati the evolutionevolucija of its ownvlastiti speciesvrsta,
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kontrolirati evoluciju vlastite vrste,
16:21
of bacteriabakterija, of plantsbilje, of animalsživotinje.
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bakterija, biljaka, životinja.
16:25
And I think that's suchtakav an ordernarudžba of magnitudeveličina changepromijeniti
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Mislim da je to promjena tolikih razmjera
16:28
that your grandkidsunuke or your great-grandkidspraunuke
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da bi vaši unuci ili praunuci
16:31
maysvibanj be a speciesvrsta very differentdrugačiji from you.
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mogli biti vrsta veoma drugačija od vaše.
16:34
Thank you very much.
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Puno vam hvala.
16:36
(ApplausePljesak)
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(Pljesak)
Translated by Suzana Barić
Reviewed by Tilen Pigac - EFZG

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ABOUT THE SPEAKER
Juan Enriquez - Futurist
Juan Enriquez thinks and writes about the profound changes that genomics and other life sciences will bring in business, technology, politics and society.

Why you should listen

A broad thinker who studies the intersections of these fields, Enriquez has a talent for bridging disciplines to build a coherent look ahead. He is the managing director of Excel Venture Management, a life sciences VC firm. He recently published (with Steve Gullans) Evolving Ourselves: How Unnatural Selection and Nonrandom Mutation Are Shaping Life on Earth. The book describes a world where humans increasingly shape their environment, themselves and other species.

Enriquez is a member of the board of Synthetic Genomics, which recently introduced the smallest synthetic living cell. Called “JCVI-syn 3.0,” it has 473 genes (about half the previous smallest cell). The organism would die if one of the genes is removed. In other words, this is the minimum genetic instruction set for a living organism.

More profile about the speaker
Juan Enriquez | Speaker | TED.com

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