Faith Osier: The key to a better malaria vaccine
Faith Osier: Kulcs egy jobb malária oltáshoz
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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diagnosztizált klinikai esetet
in Africa every year,
about malaria vaccines.
önöknek beszélni.
are simply not good enough.
egyszerűen nem elég jók.
for 100 plus years.
technológiával rendelkeztünk.
of what the parasite really looked like.
ahogy a paraziták kinéznek.
adtak nekünk arról,
the parasite really is.
has remained pretty rudimentary.
kezdetleges maradt.
we must go back to basics
vissza kell mennünk az alapokhoz,
handle this complexity.
testünk ezt az összetettséget.
infected with malaria
megfertőz a malária,
but they don't get ill.
de nem betegszenek meg.
az összetett parazitákat,
who had overcome malaria
tesztelték, melyek leküzdötték a maláriát,
antibody response look like?"
on the radar for malaria vaccines.
a malária-oltóanyagok radarján.
important parts of the parasite.
a parazita fontos részeit.
a protein of interest,
egy számunkra érdekes fehérjét,
important for a vaccine
vezetésével tesztelték,
participants in a village in Africa,
300 résztvevőt érintett,
hogy lássák,
would predict who got malaria
megjósolják-e: ki lesz maláriás,
a small number of proteins
fehérjét teszteltek
30 years of this type of research
ilyen jellegű kutatásait sűrítette bele
conducted over just three months.
három hónap leforgása alatt.
in seven African countries,
and the variable intensity
az Afrikában észlelt malária
és az életkort.
to prioritize our parasite proteins,
a paraziták fehérjéit,
a laboratóriumban,
the malaria parasite on a chip.
a malária parazitát egy csipen.
and we're very proud of that.
és nagyon büszkék vagyunk rá.
on over 100 antibody responses.
válaszából gyűjtöttünk adatot.
antibody response,
what might make a good malaria vaccine.
egy jó malária elleni oltás.
do to the parasite.
az antitestek a parazitával.
Is there synergy?
Vagy szinergia érvényesül?
a bit of one antibody won't be enough.
hogy egy antitest kis darabja nem elég.
concentrations of antibodies
kill the parasite in multiple ways,
különböző módokon ölik meg a parazitát,
may not adequately reflect reality.
az nem tükrözi híven a valóságot.
in greater definition,
látjuk a paraziták működését,
overcome this complexity.
ezt az összetettséget.
the breakthroughs that we need
a szükséges áttörést,
through vaccination.
a múlté legyen.
are we actually to a malaria vaccine?
a malária elleni vakcinához?
at the beginning of a process
a folyamat elején járunk,
what we need to put in the vaccine
hogy mit kell a vakcinába tenni,
but we're getting there.
de közeledünk felé.
tell me what does it stand for
Malaria Antigen Research Partnership.
Malária Antigén Kutatási Partnerség.
is referring to us in Africa,
in collaboration,
and looking to Europe,
és az európaiakra,
some strength within Africa.
to develop a malaria vaccine,
afrikai tudósokat is képezünk,
of disease in Africa is high,
to push the boundaries
akik tovább feszegetik
mentioned this a little bit,
if there were a malaria vaccine?
ha lenne malária elleni oltás?
half a million lives every year.
életet mentenénk meg.
12 billion US dollars a year.
évi 12 milliárd USA dollárjába kerül.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com