Faith Osier: The key to a better malaria vaccine
Faith Osier: A chave para uma vacina melhor contra a malária
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
na África todos os anos,
about malaria vaccines.
sobre vacinas contra a malária.
are simply not good enough.
simplesmente não são boas o bastante.
for 100 plus years.
por mais de 100 anos.
a tecnologia era limitada.
of what the parasite really looked like.
da aparência real do parasita.
uma visão mais clara
the parasite really is.
has remained pretty rudimentary.
tem permanecido bem rudimentar.
we must go back to basics
devemos voltar ao básico
handle this complexity.
lida com essa complexidade.
infected with malaria
infectadas com malária
but they don't get ill.
à nossa parasita complexa,
who had overcome malaria
que superaram a malária
antibody response look like?"
de anticorpos bem-sucedida?"
on the radar for malaria vaccines.
para vacinas contra a malária.
important parts of the parasite.
perdendo partes importantes do parasita.
a protein of interest,
identificada uma proteína de interesse,
important for a vaccine
ser importante para uma vacina
participants in a village in Africa,
300 participantes de uma aldeia na África,
would predict who got malaria
iriam prever quem tinha malária
a small number of proteins
um pequeno número de proteínas
30 years of this type of research
30 anos desse tipo de pesquisa
conducted over just three months.
conduzido em apenas três meses.
in seven African countries,
em 7 países africanos,
and the variable intensity
e a intensidade variável
to prioritize our parasite proteins,
nossas proteínas parasitas,
the malaria parasite on a chip.
a parasita da malária em um chip.
and we're very proud of that.
e estamos muito orgulhosos disso.
on over 100 antibody responses.
em mais de 100 respostas de anticorpos.
antibody response,
de anticorpos de sucesso,
what might make a good malaria vaccine.
fazer uma boa vacina contra a malária.
do to the parasite.
fazem com o parasita.
Is there synergy?
Existe sinergia?
de um anticorpo não será o bastante.
a bit of one antibody won't be enough.
concentrations of antibodies
concentrações de anticorpos
kill the parasite in multiple ways,
matam o parasita de várias maneiras,
may not adequately reflect reality.
não refletiria a realidade adequadamente.
in greater definition,
em maior definição,
overcome this complexity.
supera essa complexidade.
the breakthroughs that we need
os avanços que precisamos
through vaccination.
através da vacinação.
are we actually to a malaria vaccine?
de uma vacina contra a malária?
at the beginning of a process
no início de um processo
what we need to put in the vaccine
o que precisamos colocar na vacina
but we're getting there.
da vacina, mas estamos chegando lá.
tell me what does it stand for
diga-nos o que significa
Malaria Antigen Research Partnership.
Malaria Antigen Research Partnership.
is referring to us in Africa,
in collaboration,
and looking to Europe,
para os EUA e para a Europa,
some strength within Africa.
to develop a malaria vaccine,
uma vacina contra a malária,
cientistas africanos,
of disease in Africa is high,
to push the boundaries
que continuarão a empurrar os limites
¶
mentioned this a little bit,
if there were a malaria vaccine?
se houvesse uma vacina contra a malária?
half a million lives every year.
12 billion US dollars a year.
US$ 12 bilhões ao ano.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com