Faith Osier: The key to a better malaria vaccine
페이스 오지어(Faith Osier): 더 나은 말라리아 백신개발을 위한 열쇠
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
Double-click the English transcript below to play the video.
열대성 말라리아로 진단받는 경우가
in Africa every year,
그로 인한 사망자는
about malaria vaccines.
말씀드리고 싶습니다.
are simply not good enough.
충분히 효과적이지가 않습니다.
for 100 plus years.
연구를 해오고 있습니다.
기술의 한계가 있었죠.
of what the parasite really looked like.
극히 일부분만 관찰할 수 있었죠.
the parasite really is.
has remained pretty rudimentary.
여전히 기초적 수준에 머물러 있죠.
we must go back to basics
기본으로 돌아가야 합니다.
handle this complexity.
처리하는지 이해하기 위해서 말이죠.
infected with malaria
but they don't get ill.
다시 살펴봤습니다.
who had overcome malaria
샘플을 조사했습니다.
antibody response look like?"
단백질을 발견하였고
on the radar for malaria vaccines.
범위에 없었습니다.
important parts of the parasite.
중요한 것을 놓치고 있었던 것 같아요.
a protein of interest,
식별한 경우에는
important for a vaccine
여부를 판단하기 위해서
participants in a village in Africa,
300여명의 참여자를 대상으로 하며
would predict who got malaria
알아보기 위해서 샘플을 분석하였습니다.
a small number of proteins
테스트 해왔었죠.
30 years of this type of research
이러한 유형의 연구들을 단 3개월안에
conducted over just three months.
하나의 실험으로 압축하였습니다.
샘플을 수집했죠.
in seven African countries,
and the variable intensity
말라리아의 강도 등을 고려해서요.
to prioritize our parasite proteins,
기생충 단백질의 우선순위를 정하고
the malaria parasite on a chip.
재탄생시켰다는 의미입니다.
and we're very proud of that.
저희는 매우 자랑스럽게 생각합니다.
on over 100 antibody responses.
항체반응 자료를 수집하였습니다.
antibody response,
어떻게 일어나는지 알아서
what might make a good malaria vaccine.
무엇이 필요한지 예측하고자 합니다.
do to the parasite.
어떤 작용을 하는지입니다 .
Is there synergy?
시너지 효과가 있을까?
a bit of one antibody won't be enough.
충분하지 않음을 시사합니다.
concentrations of antibodies
kill the parasite in multiple ways,
다양한 방법이 있음을 알아냈습니다.
may not adequately reflect reality.
현실을 충분히 반영할 수 없습니다.
in greater definition,
관찰할 수 있는 것처럼
overcome this complexity.
이해하는데 초점을 맞추고 있습니다.
the breakthroughs that we need
말라리아의 새로운 역사를 쓰기 위해서
through vaccination.
있다고 믿고 있습니다.
are we actually to a malaria vaccine?
실질적으로 얼마나 근접해 있는거죠?
at the beginning of a process
걸음마 단계에 있는거죠.
what we need to put in the vaccine
무엇을 백신에 포함시켜야 할지를
but we're getting there.
아니지만 서서히 다가가는 중이죠.
tell me what does it stand for
어떤 의미가 있고
Malaria Antigen Research Partnership.
항원 연구 조합을 의미하구요.
is referring to us in Africa,
아프리카의 저희 연구팀을 가리켜요.
in collaboration,
and looking to Europe,
배우던 것과는 대조적으로
some strength within Africa.
발휘하는 중입니다.
to develop a malaria vaccine,
목표도 있을 뿐만 아니라,
힘쓰고 있죠.
of disease in Africa is high,
질병에 대한 위험부담이 높고
to push the boundaries
지속적으로 넓혀 나가야 할
mentioned this a little bit,
if there were a malaria vaccine?
실제로 상황은 어떻게 달라지나요?
half a million lives every year.
구할 수 있을 거예요.
12 billion US dollars a year.
약 120억 달러의 비용이 들죠.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com