Faith Osier: The key to a better malaria vaccine
Faith Osier: Daha iyi bir sıtma aşısının anahtarı
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
about malaria vaccines.
are simply not good enough.
yeterince iyi olmadığı ortada.
for 100 plus years.
fazladır çalışıyoruz.
of what the parasite really looked like.
küçük bir parçasını görerek anlayabildik.
karmaşık olduğunun
the parasite really is.
aşının tasarımına olan
has remained pretty rudimentary.
we must go back to basics
handle this complexity.
anlamak için özümüze dönmek durumundayız.
infected with malaria
but they don't get ill.
ama hastalanmıyorlar.
parazitimizin üstüne gitti,
who had overcome malaria
alınan örneklerle araştırdı.
antibody response look like?"
tepkisi nasıl olur?"
on the radar for malaria vaccines.
important parts of the parasite.
kısımlarını gözden kaçırıyor olabilir.
a protein of interest,
bir protein saptadığında
important for a vaccine
o proteinin aşı için
participants in a village in Africa,
örnekleri alınıp incelenen
would predict who got malaria
sıtma kaptığını ve kimin kapmadığını
a small number of proteins
30 years of this type of research
bu tarzda bir araştırmayı,
conducted over just three months.
heyecan verici deney ile yıktı.
ve değişken yoğunluğu farklı olarak
in seven African countries,
yedi Afrika ülkesinden
and the variable intensity
to prioritize our parasite proteins,
öncelik vermek,
the malaria parasite on a chip.
bir çipte yeniden yarattık.
and we're very proud of that.
gurur duyuyoruz.
on over 100 antibody responses.
tepkisinden veri topladık.
antibody response,
what might make a good malaria vaccine.
nasıl yapılacağını tahmin edebilelim diye.
do to the parasite.
anlamaya çalışıyoruz.
Is there synergy?
Birliktelik var mı?
a bit of one antibody won't be enough.
olmasının yeterli olmayacağını söylüyor.
concentrations of antibodies
antikora gerek olabilir.
kill the parasite in multiple ways,
yolla öldürdüklerini öğreniyor
may not adequately reflect reality.
incelemek gerçeği yansıtmayabilir.
in greater definition,
anlamıyla görebildiğimiz gibi
overcome this complexity.
ettiğine anlamaya odaklanmış durumdayız.
the breakthroughs that we need
geçmemiz için gereken dönüm noktalarını
through vaccination.
are we actually to a malaria vaccine?
ne kadar yakınız?
at the beginning of a process
what we need to put in the vaccine
but we're getting there.
ama o yöne doğru gidiyoruz.
tell me what does it stand for
söyleyecek olursanız mesela
Malaria Antigen Research Partnership.
Araştırma Ortaklık'ı anlamına geliyor.
is referring to us in Africa,
in collaboration,
bizleri temsil ediyor.
and looking to Europe,
Avrupa'ya bakmanın aksine
some strength within Africa.
to develop a malaria vaccine,
amacımızın yanında
of disease in Africa is high,
hastalığın faturası ağır,
to push the boundaries
sınırlarını zorlamaya devam edecek
mentioned this a little bit,
if there were a malaria vaccine?
bazı şeyler gerçekten değişir miydi?
half a million lives every year.
hayatı kurtarmış olurduk.
12 billion US dollars a year.
dolara mal olduğu tahmin ediliyor.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com