Jennifer Pluznick: You smell with your body, not just your nose
ג'ניפר פלצניק: אתם מריחים עם הגוף, לא רק האף
Jennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors. Full bio
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do you think you can smell,
שאתם מסוגלים להריח,
detect up to one trillion different odors.
כטריליון ריחות שונים.
machinery to make it happen.
to be activated by the odor,
like all vertebrates,
to genes for different olfactory receptors
be doing something else
uncovered the molecular identity
של קולטני חוש הריח --
led to a Nobel Prize.
were only found in the nose.
receptor expressed in a tissue
נמצאו ברקמות
are found all over the body,
נמצאים בכל הגוף,
unexpected places --
act as sensitive chemical sensors
פועלים כחיישני כימיקלים רגישים באף --
our sense of smell.
as sensitive chemical sensors
detect the aroma of your morning coffee
לקלוט את הארומה של הקפה של הבוקר
your morning coffee,
the change in concentration
through your bloodstream.
use chemical sensors,
משתמשים בחיישנים כימיים
of hormones, metabolites
הורמונים, מטבוליטים
are olfactory receptors.
מהסוג של קולטני חוש הריח.
of a specific molecule,
found outside the nose
express an olfactory receptor,
בזרע של בני אדם,
will seek out the chemical
will swim toward the ligand.
with the highest ligand concentration?
הליגנד הגבוה ביותר?
because it clearly demonstrates
שהיא מדגימה בצורה מאוד ברורה
is to be a chemical sensor,
הם להיות חיישנים כימים,
implicated in muscle cell migration,
בנדידת תאי שריר,
and respond to inhaled chemicals,
לכימיכלים שנקלטו בשאיפה,
to be found only in the tongue,
נחשב כי היו קיימים על הלשון בלבד,
in cells and tissues throughout the body.
בתאים וברקמות בכל חלקי הגוף.
also play a role in our blood vessels.
גם משחקים תפקיד חשוב בכלי הדם שלנו.
of olfactory receptors and taste receptors
של קולטני חוש הריח וחוש הטעם
control center for homeostasis.
control center would be a logical place
יהיה מקום מתקבל על הדעת
of different olfactory and taste receptors
in cells and tissues
in the regulation of blood pressure.
was found to respond
short-chain fatty acids
that reside in your gut --
by your gut microbiota,
into your bloodstream
interact with receptors
in metabolism of your gut microbiota
של המיקרוביוטה במעי
of different olfactory and taste receptors
to tease out their different functions
each of them responds to.
for many other organs and tissues --
עבור רקמות ואיברים רבים ואחרים --
has been studied to date.
of the scope of influence
to change our understanding
of something we're following.
של משבו שאנו עוקבים אחריו
ABOUT THE SPEAKER
Jennifer Pluznick - PhysiologistJennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors.
Why you should listen
Jennifer Pluznick's fascination with understanding how interactions at the molecular level affect functions at the organismal level led her to pursue a Ph.D. in renal physiology from the University of Nebraska Medical Center. While researching kidney disease as part of her postdoc at Yale University, Pluznick came across scent receptors in the kidney. She initially wrote off this surprising finding as a fluke, but after taking a second look, she realized how important this discovery could be for understanding kidney function. Since 2010, Pluznick and her lab at the Johns Hopkins School of Medicine have researched the role of the olfactory signaling system. Most recently, they’ve found a possible connection between the bacteria in your gut and how your kidney manages blood pressure.
Jennifer Pluznick | Speaker | TED.com