Jennifer Pluznick: You smell with your body, not just your nose
Jennifer Pluznick: Yalnızca burnunuzla değil, tüm vücudunuzla koku alıyorsunuz
Jennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors. Full bio
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do you think you can smell,
ve hatta bu kokuları
detect up to one trillion different odors.
farklı kokuyu alabildiklerini söylüyor.
gerekli moleküler yapıya sahip.
machinery to make it happen.
to be activated by the odor,
like all vertebrates,
to genes for different olfactory receptors
farklı koku alıcıları genlerine,
be doing something else
sağlamanın yanı sıra,
uncovered the molecular identity
koku alıcılarının
led to a Nobel Prize.
olduğunu sanıyorduk.
were only found in the nose.
görülen bir koku alıcısına ilişkin
receptor expressed in a tissue
are found all over the body,
her tarafında olduğunu biliyoruz,
unexpected places --
act as sensitive chemical sensors
hassas kimyasal sensörler
harekete geçiriyorlar.
our sense of smell.
as sensitive chemical sensors
hassas kimyasal sensörler olarak
detect the aroma of your morning coffee
sabah kahvenizin aromasını
your morning coffee,
the change in concentration
through your bloodstream.
use chemical sensors,
kimyasal sensörler kullanırlar,
ve diğer moleküllerin
of hormones, metabolites
koku alıcılarıdır.
are olfactory receptors.
ihtiyacınız olsa,
of a specific molecule,
found outside the nose
express an olfactory receptor,
kullandığını gösterdi,
will seek out the chemical
will swim toward the ligand.
with the highest ligand concentration?
because it clearly demonstrates
çünkü bize şunu açıkça gösteriyor;
is to be a chemical sensor,
kimyasal bir sensör olmaktır,
başka süreçleri etkileyebilir.
implicated in muscle cell migration,
and respond to inhaled chemicals,
sezme ve cevap vermede
to be found only in the tongue,
ilk önce sadece dilde olduğu sanılıyordu,
in cells and tissues throughout the body.
hücre ve dokularda var olduğu biliniyor.
also play a role in our blood vessels.
dolaşım sistemimizde rolü olduğunu buldu.
of olfactory receptors and taste receptors
ne tür bir rol oynadıklarını
control center for homeostasis.
merkezi kontrol birimi.
homeostazi kontrol birimi
control center would be a logical place
of different olfactory and taste receptors
koku ve tat alıcıları
in cells and tissues
in the regulation of blood pressure.
was found to respond
short-chain fatty acids
bakteriler tarafından üretilen,
that reside in your gut --
denilen kimyasallara
by your gut microbiota,
into your bloodstream
tarafından emiliyor,
interact with receptors
in metabolism of your gut microbiota
metabolik değişimlerin
anlamına geliyor.
of different olfactory and taste receptors
koku ve tat alıcısı
to tease out their different functions
each of them responds to.
anlamaya yeni yeni başladık.
for many other organs and tissues --
benzer araştırmalar önümüzde,
has been studied to date.
bir azınlık üzerinde araştırma yapıldı.
of the scope of influence
etki kapsamını anlayabilmek
to change our understanding
of something we're following.
kokusunu alıyorum.
ABOUT THE SPEAKER
Jennifer Pluznick - PhysiologistJennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors.
Why you should listen
Jennifer Pluznick's fascination with understanding how interactions at the molecular level affect functions at the organismal level led her to pursue a Ph.D. in renal physiology from the University of Nebraska Medical Center. While researching kidney disease as part of her postdoc at Yale University, Pluznick came across scent receptors in the kidney. She initially wrote off this surprising finding as a fluke, but after taking a second look, she realized how important this discovery could be for understanding kidney function. Since 2010, Pluznick and her lab at the Johns Hopkins School of Medicine have researched the role of the olfactory signaling system. Most recently, they’ve found a possible connection between the bacteria in your gut and how your kidney manages blood pressure.
Jennifer Pluznick | Speaker | TED.com