Tal Danino: Programming bacteria to detect cancer (and maybe treat it)
Tal Danino - Synthetic biologist
Tal Danino explores the emerging frontier of combining biology and engineering (and art). He is a 2015 TED Fellow. Full bio
than stars in our entire galaxy.
of bacteria inside of us
like we program computers.
some kind of sports play,
the first bacterial program I developed.
we can print and write DNA
and programs inside of bacteria.
is produces fluorescent proteins
to communicate and synchronize,
that you see here
is that our genetic program
to each produce small molecules,
the thousands of individual bacteria
quite well at this scale,
them together can only travel so fast,
this results in traveling waves
far away from each other,
from right to left across the screen.
relies on a natural phenomenon
and sometimes virulent behaviors
in action in this movie,
only begins to glow
or critical density.
rhythmic patterns of fluorescent proteins
we call The Supernova,
these beautiful patterns,
these bacteria to do?
how we can program bacteria
in our bodies like cancer.
inside of tumors.
has no access,
to grow and thrive.
that have a health benefit,
when orally delivered to mice,
grow inside of liver tumors.
of the probiotics,
to produce a signal
programmed these probiotics
the color of your urine
detect liver cancer,
to detect otherwise.
specifically localize to tumors,
to not only detect cancer
from within the tumor environment
using quorum sensing programs
taking a programmed probiotic
I worked with artist Vik Muniz
or cancer cells.
and purpose of this microscopic universe
for the future of cancer research.
About the speaker:Tal Danino - Synthetic biologist
Tal Danino explores the emerging frontier of combining biology and engineering (and art). He is a 2015 TED Fellow.
Why you should listen
Tal Danino's research focuses on understanding how networks of genes interact in biological systems, and developing design principles to re-engineer new biological behaviors that have practical applications.
He is a postdoctoral fellow at MIT in the Laboratory for Multiscale Regenerative Technologies, Sangeeta Bhatia's lab, as well as a visiting fellow at the Rockefeller University in New York City. As a postdoctoral fellow, he researches the use of bacteria as cancer diagnostics and therapeutics. His research has been published in scientific journals such as Nature, Science, and Cell.
Tal Danino | Speaker | TED.com