David Brenner: A new weapon in the fight against superbugs
David Brenner: Una nueva arma para combatir las superbacterias
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
de una verdadera guerra en este momento
por qué les muestro
of some soccer fans --
de hinchas del Liverpool,
celebrating a famous victory
en Estambul hace una década.
bueno, ese soy yo
that's my friend Paul Rice.
está mi amigo Paul Rice.
de que se tomó esta foto
after this picture was taken,
para una cirugía menor,
for some minor surgery,
a superbug-related infection,
debida a las superbacterias y murió.
un hombre sano en la flor de la vida.
de un par de personas de TED,
from a couple of TEDsters,
contra las superbacterias.
personal war on superbugs.
por un momento.
for a moment.
introduction of antibiotics.
de los antibióticos.
bacterias resistentes a las drogas
have continued to emerge,
a desarrollar más y más drogas nuevas
newer and newer drugs
actually is the origin of superbugs,
el origen de las superbacterias,
para las que no tenemos drogas efectivas.
for which we don't have effective drugs.
al menos algunas de estas superbacterias.
at least some of these superbugs.
common ones around today.
que están en circulación hoy.
de 700 000 personas murieron
relacionadas con las superbacterias.
el camino que llevamos,
un enfoque basado en las drogas,
approach to the problem,
para mediados del siglo
by the middle of this century
from superbugs will be 10 million.
por superbacterias estarán en 10 millones.
that's actually more
el año pasado a nivel mundial.
that died of cancer worldwide last year.
que no vamos por buen camino
that we're not on a good road,
to this problem is not working.
en las drogas no está funcionando.
cómo podemos enfocar esto desde la física,
a physics-based approach --
de manera distinta.
lo primeo que sé a ciencia cierta
cómo matar cada tipo de microbio,
every kind of microbe,
for more than 100 years.
lo que es la luz ultravioleta.
what ultraviolet light is.
that includes infrared,
a la luz infrarroja y a la luz visible.
of this group is ultraviolet light.
de ese grupo es la luz ultravioleta.
desde nuestra perspectiva,
mata a las bacterias
by a completely different mechanism
distinto al que usan las drogas.
es tan capaz de matar
of killing a drug-resistant bacteria
como a cualquier otra bacteria.
es buena para matar bacterias
is so good at killing all bugs,
para esterilizar habitaciones
to sterilize rooms,
ultraviolet light.
con luz ultravioleta germicida.
in this picture, actually,
y hay una buena razón para ello.
is actually a health hazard,
es un peligro para la salud,
causar cáncer de piel;
causar enfermedades como las cataratas.
luz ultravioleta germicida convencional
germicidal, ultraviolet light
especialmente cuando hay gente alrededor.
when there are people around.
to kill all bacteria,
incluyendo las superbacterias,
expuestos a ella.
background kicked into this story.
tiene relevancia en esta historia.
wavelength of ultraviolet light
de una longitud de onda particular,
y debería ser segura para los humanos.
se llama "luz UVC lejana"
of the ultraviolet spectrum.
de longitud de onda corta.
es la superficie de nuestra piel
is the surface of our skin,
al aire que está sobre la piel.
some bacteria in the air above the skin.
ultraviolet light impinges on this.
convencional choca contra esto.
germicida es excelente matando bacterias,
is really good at killing bacteria,
las capas superiores de nuestra piel
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
pueden conducir al cáncer.
bacterias en el aire encima de ella.
in the air above them.
es perfectamente capaz de matar bacterias,
perfectly fine at killing bacteria,
no puede hacer es penetrar nuestra piel.
is penetrate into our skin.
razón física para eso:
solid physics reason for that:
absorbed by all biological materials,
y fuertemente absorbida
así que no puede ir muy lejos.
son realmente pequeños,
are really, really, really small,
penetrate them and kill them,
penetrarlos y matarlos... a ellos,
is penetrate into skin,
el área de células muertas
the dead-cell area
should be able to kill bacteria,
debiera poder matar bacterias
debiera ser segura.
¿Realmente es segura?
en esto los últimos seis años
has been working on
a las dos preguntas es un enfático "sí".
to both these questions
aunque no estoy muy sorprendido
surprised to say that,
of physics at work.
las leyes de la física en acción.
a completely new weapon,
un arma completamente nueva,
en la lucha contra las superbacterias.
en los quirófanos.
donde se preparan comidas.
in food preparation areas.
the spread of viruses,
la proliferación de los virus,
previniendo el contagio de la gripe,
in airports or airplanes,
en los aeropuertos y aviones
of viruses like H1N1 virus.
de virus como el H1N1.
and well-loved local politician
en nuestra ciudad natal: Liverpool.
erigieron una estatua en su memoria.
in the center of Liverpool,
in this war against superbugs.
contra las superbacterias,
tengo una pregunta para ti.
I've got a question for you.
in developing this,
en el desarrollo de esto
to trying to roll out
para cumplir este sueño.
sabemos que mata a las bacterias,
that it kills all bacteria,
that before we started,
pero ahora está comprobado.
sobre qué tan seguro es,
of tests about safety,
than it is about efficacy.
que sobre eficacia.
a corto plazo y a largo plazo
de unos años no vayas a tener melanoma.
melanoma many years on.
are pretty well done at this point.
bastante listos en este momento.
we have to deal with,
algo con lo que tenemos que lidiar,
in the real world without FDA approval.
sin la aprobación de la FDA.
to launch first in the US,
en EE. UU. o en algún otro lado?
biologists, doctors,
de que es un tratamiento seguro?
hay cierto escepticismo
there is a certain skepticism
that UV light is not safe.
que la luz UV es peligrosa.
esta luz UV en particular es inofensiva",
pero los datos están ahí
we're going to be standing on.
con lo que lo sustentaremos.
es un trabajo muy importante.
for sharing this with us.
compartirlo con nosotros, David.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com