David Brenner: A new weapon in the fight against superbugs
David Brenner: Dirençli bakterilere karşı savaşta yeni bir silah
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
olduğumuzu söyleyebilirim
of some soccer fans --
gösterdiğimi merak edebilirsiniz.
celebrating a famous victory
10 yıl önce İstanbul'da,
that's my friend Paul Rice.
arkadaşım Paul Rice.
after this picture was taken,
iki yıl sonra
for some minor surgery,
hastaneye yattı,
a superbug-related infection,
bir enfeksiyona yakalandı
from a couple of TEDsters,
personal war on superbugs.
for a moment.
introduction of antibiotics.
tanıtımıyla başlıyor.
have continued to emerge,
ortaya çıkmaya devam etti,
newer and newer drugs
sürekli yeni ilaç geliştirmek
actually is the origin of superbugs,
aslında dirençli bakterilerin hikâyesi,
for which we don't have effective drugs.
bakteriler yani.
at least some of these superbugs.
tanıyor olmalısınız.
common ones around today.
dirençli bakterilere bağlı
approach to the problem,
ilaç temelli bir yaklaşım,
by the middle of this century
en iyi ihtimalle
from superbugs will be 10 million.
sebebiyle ölüm oranı 10 milyon olacak.
that's actually more
that died of cancer worldwide last year.
insan sayısından daha fazla.
that we're not on a good road,
to this problem is not working.
işe yaramıyor.
a physics-based approach --
geliştirebilir miyiz diye merak ettim,
every kind of microbe,
for more than 100 years.
zamandır biliyoruz.
what ultraviolet light is.
biliyorsunuzdur.
that includes infrared,
içine alan
of this group is ultraviolet light.
ultraviyole ışını.
by a completely different mechanism
ilaçlara kıyasla çok daha farklı
of killing a drug-resistant bacteria
dirençli bakterileri
is so good at killing all bugs,
öldürebildiği için de
to sterilize rooms,
ultraviyole ışını kullanılarak
ultraviolet light.
görüyorsunuz.
in this picture, actually,
is actually a health hazard,
sağlık açısından tehlikelidir,
germicidal, ultraviolet light
ultraviyole ışınlarını
when there are people around.
to kill all bacteria,
background kicked into this story.
devreye girdi.
wavelength of ultraviolet light
tüm bakterileri öldürecek,
of the ultraviolet spectrum.
sadece kısa dalga uzunluğu parçası.
is the surface of our skin,
some bacteria in the air above the skin.
bakteri ekliyorum,
ultraviolet light impinges on this.
olduğunu bir bakalım.
is really good at killing bacteria,
bakteriyi öldürmede oldukça etkili
into the upper layers of our skin,
those key cells in our skin
cilt kanseri gibi
can lead to skin cancer.
önemli hücrelere zarar verebiliyor.
in the air above them.
perfectly fine at killing bacteria,
bakterileri kusursuzca öldürürken
is penetrate into our skin.
solid physics reason for that:
makul bir açıklaması var:
absorbed by all biological materials,
tarafından inanılmaz bir güçle emiliyor,
are really, really, really small,
penetrate them and kill them,
ve onları öldürebilir
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
has been working on
laboratuvarımız
to both these questions
yanıtlamaktan
surprised to say that,
of physics at work.
fizik kurallarından ibaret.
a completely new weapon,
tamamen yeni bir silahımız
görebiliyorum.
in food preparation areas.
the spread of viruses,
in airports or airplanes,
H1N1 gibi virüslerin
of viruses like H1N1 virus.
kullanıldığını görebiliyorum.
and well-loved local politician
tanınan ve çok sevilen
in the center of Liverpool,
bir heykel diktiler,
in this war against superbugs.
büyük bir ilerlemeyi temsil etmesi.
I've got a question for you.
Sana bir sorum var.
in developing this,
hangi aşamada olduğumuzu
to trying to roll out
hangi engellerin olduğunu
that it kills all bacteria,
öldürdüğü bildiğimiz bir gerçek
that before we started,
biliyorduk
of tests about safety,
çok test yapmamız gerek.
than it is about efficacy.
güvenliğiyle ilgili.
hem kısa vadeli
melanoma many years on.
yapmamız gerek.
are pretty well done at this point.
iyi bir şekilde yapılıyor.
we have to deal with,
in the real world without FDA approval.
bunu gerçek hayatta kullanamayız.
to launch first in the US,
yoksa başka bir yerde mi
biologists, doctors,
bunun güvenli bir yaklaşım olduğu
there is a certain skepticism
buna karşı büyük bir şüphe var
that UV light is not safe.
olmadığını herkes biliyor.
we're going to be standing on.
dayanabileceğimizi düşünüyorum.
for sharing this with us.
teşekkürler.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com