David Brenner: A new weapon in the fight against superbugs
David Brenner: Un nou instrument în lupta împotriva superbacteriilor
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
în acest moment,
împotriva superbacteriilor.
despre superbacterii,
of some soccer fans --
cu niște microbiști,
celebrating a famous victory
care sărbătoresc o mare victorie
that's my friend Paul Rice.
acela era prietenul meu, Paul Rice.
after this picture was taken,
fotografie a fost făcută,
for some minor surgery,
pentru o operație ușoară,
a superbug-related infection,
from a couple of TEDsters,
din partea unor contributori TED,
personal war on superbugs.
împotriva superbacteriilor.
for a moment.
introduction of antibiotics.
a antibioticelor.
have continued to emerge,
au continuat să apară,
newer and newer drugs
noi și noi medicamente
acestor noi bacterii.
actually is the origin of superbugs,
originea superbacteriilor,
for which we don't have effective drugs.
medicamente eficiente.
at least some of these superbugs.
măcar câteva dintre aceste superbacterii.
common ones around today.
în jur de 700.000 de oameni
provocate de superbacterii.
approach to the problem,
problema folosind antibiotice,
by the middle of this century
la mijlocul secolului
from superbugs will be 10 million.
vor ajunge la 10 milioane.
that's actually more
asta reprezintă mai mult
that died of cancer worldwide last year.
care au murit de cancer anul trecut.
that we're not on a good road,
nu suntem pe calea cea bună,
to this problem is not working.
folosind antibiotice nu funcționează.
a physics-based approach --
o abordare a problemei prin fizică,
every kind of microbe,
fiecare tip de microb,
for more than 100 years.
what ultraviolet light is.
ce e lumina ultravioletă.
that includes infrared,
ce include infraroșu,
of this group is ultraviolet light.
e lumina ultravioletă.
by a completely different mechanism
printr-un mecanism complet diferit
distrug bacteriile.
of killing a drug-resistant bacteria
bacterii rezistente la medicament,
is so good at killing all bugs,
eficientă în a distruge toate bacteriile,
to sterilize rooms,
pentru a steriliza încăperi,
o sală de operații
ultraviolet light.
ultravioletă germicidă.
in this picture, actually,
is actually a health hazard,
e periculoasă pentru sănătate
celulele din piele,
precum cataracta.
germicidal, ultraviolet light
lumina ultravioletă convențională
when there are people around.
acolo unde sunt oameni.
to kill all bacteria,
să distrugă toate bacteriile,
și pentru oameni.
background kicked into this story.
cunoștințele mele de fizică.
wavelength of ultraviolet light
o lungime de undă a luminii ultraviolete
toate bacteriile,
pentru expunerea umană.
lumina ultravioletă UV-C,
of the ultraviolet spectrum.
cea mai scurtă din spectrul ultraviolet.
is the surface of our skin,
some bacteria in the air above the skin.
ultraviolet light impinges on this.
intră în contact cu pielea.
is really good at killing bacteria,
e foarte eficace în a distruge bacterii,
into the upper layers of our skin,
în straturile superioare ale pielii,
those key cells in our skin
acele celule cheie din piele
can lead to skin cancer.
când sunt deteriorate.
cu lumina ultravioletă UV-C,
in the air above them.
cu bacteriile din aer.
perfectly fine at killing bacteria,
e perfect letală pentru bacterii.
is penetrate into our skin.
nu poate penetra în piele.
solid physics reason for that:
și întemeiat pentru aceasta:
absorbed by all biological materials,
absorbită de toate materialele biologice,
are really, really, really small,
foarte, foarte mici,
penetrate them and kill them,
în mod sigur să îi distrugă,
is penetrate into skin,
the dead-cell area
zona de celule moarte
should be able to kill bacteria,
poate distruge toate bacteriile,
ar trebui să fie sigură.
has been working on
să dovedească acest lucru
to both these questions
la ambele întrebări
surprised to say that,
of physics at work.
a completely new weapon,
o armă complet nouă,
superbacteriilor.
în sălile de operații.
in food preparation areas.
în locurile unde se prepară alimente,
the spread of viruses,
răspândirii virusurilor,
in airports or airplanes,
în aeroporturi și avioane,
of viruses like H1N1 virus.
a unor virusurilor precum H1N1.
Paul Rice.
and well-loved local politician
cunoscut și iubit de toți
in the center of Liverpool,
în memoria sa în centrul orașului,
in this war against superbugs.
în războiul împotriva superbacteriilor.
I've got a question for you.
am o întrebare pentru tine.
in developing this,
în acest proces,
to trying to roll out
that it kills all bacteria,
că distruge toate bacteriile,
that before we started,
of tests about safety,
cu privire la siguranță,
than it is about efficacy.
decât de eficacitate.
melanoma many years on.
cauzează apariția melanomului peste ani.
are pretty well done at this point.
până în acest punct.
we have to deal with,
cu reglementările FDA,
in the real world without FDA approval.
în lumea reală fără aprobarea FDA.
to launch first in the US,
prima dată în SUA,
biologists, doctors,
there is a certain skepticism
o doză de scepticism
that UV light is not safe.
că lumina ultravioletă nu e sigură.
este sigură,”
we're going to be standing on.
că ne-ai împărtășit asta.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com