David Brenner: A new weapon in the fight against superbugs
大衛布倫納: 對抗超級病菌的新武器
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
一些足球迷的照片?
of some soccer fans --
celebrating a famous victory
正在慶祝一場著名的勝仗,
是我的朋友保羅萊斯。
that's my friend Paul Rice.
after this picture was taken,
for some minor surgery,
a superbug-related infection,
from a couple of TEDsters,
personal war on superbugs.
for a moment.
introduction of antibiotics.
have continued to emerge,
newer and newer drugs
actually is the origin of superbugs,
有效藥物可以對抗的細菌。
for which we don't have effective drugs.
at least some of these superbugs.
其中幾種超級病菌。
common ones around today.
approach to the problem,
為基礎的方法來解決問題,
by the middle of this century
因為感染超級病菌而死亡,
from superbugs will be 10 million.
that's actually more
that died of cancer worldwide last year.
that we're not on a good road,
不是很理想。
來解決這個問題是行不通的。
to this problem is not working.
可以用以物理為基礎的方法,
a physics-based approach --
every kind of microbe,
殺死每一種微生物,
for more than 100 years.
what ultraviolet light is.
that includes infrared,
光譜上包括了紅外線,
of this group is ultraviolet light.
by a completely different mechanism
of killing a drug-resistant bacteria
那些能抵抗藥物的細菌,
is so good at killing all bugs,
殺死所有的細菌,
to sterilize rooms,
ultraviolet light.
in this picture, actually,
is actually a health hazard,
germicidal, ultraviolet light
when there are people around.
to kill all bacteria,
background kicked into this story.
進入這個故事的地方了。
wavelength of ultraviolet light
of the ultraviolet spectrum.
is the surface of our skin,
加上一些的細菌。
some bacteria in the air above the skin.
在上面照射後會發生什麼事。
ultraviolet light impinges on this.
is really good at killing bacteria,
真的很擅長殺死細菌,
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
最終可能就會導致皮膚癌。
in the air above them.
perfectly fine at killing bacteria,
is penetrate into our skin.
solid physics reason for that:
而且很可靠的物理理由:
absorbed by all biological materials,
以不可思議的程度強力吸收,
are really, really, really small,
可以穿透並殺死它們。
penetrate them and kill them,
is penetrate into skin,
the dead-cell area
表面的死細胞區域。
should be able to kill bacteria,
has been working on
我們的實驗室在努力的,
to both these questions
這兩個問題的答案,
surprised to say that,
of physics at work.
a completely new weapon,
我感到很興奮,
in food preparation areas.
the spread of viruses,
in airports or airplanes,
of viruses like H1N1 virus.
and well-loved local politician
且受愛戴的當地政治家,
in the center of Liverpool,
為他立了一座紀念雕像,
在超級病菌之戰中的重大進展。
in this war against superbugs.
I've got a question for you.
我有個問題想請教。
in developing this,
你們開發這個的目的是什麼?
to trying to roll out
that it kills all bacteria,
我們現在知道它能殺死所有細菌,
that before we started,
of tests about safety,
安全相關的測試,
than it is about efficacy.
在多年之後得到黑色素瘤。
melanoma many years on.
are pretty well done at this point.
we have to deal with,
食品及藥物管理局批准,
in the real world without FDA approval.
就一定要先有食品及藥物管理局的核准。
to launch first in the US,
biologists, doctors,
說服了生物學家及醫生,
there is a certain skepticism
一定有人會抱持懷疑態度,
that UV light is not safe.
we're going to be standing on.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com