David Brenner: A new weapon in the fight against superbugs
David Brenner: Új fegyver a rezisztens baktériumok elleni küzdelemben
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
of some soccer fans --
készült fotót mutatok,
celebrating a famous victory
that's my friend Paul Rice.
Paul Rice barátom.
after this picture was taken,
for some minor surgery,
miatt került kórházba,
a superbug-related infection,
miatti fertőzést kapott,
from a couple of TEDsters,
personal war on superbugs.
antibiotikum-rezisztens baktériumok ellen.
for a moment.
introduction of antibiotics.
have continued to emerge,
newer and newer drugs
mind újabb gyógyszereket kifejleszteni
actually is the origin of superbugs,
a gyógyszer-rezisztenciát:
for which we don't have effective drugs.
amelyek ellen nincs hatékony gyógyszer.
at least some of these superbugs.
ellenálló baktériumot ismernek.
common ones around today.
ezek a leggyakoribbak.
approach to the problem,
megoldását jelenti,
by the middle of this century
századunk derekára
from superbugs will be 10 million.
halálozások száma eléri a 10 milliót.
that's actually more
that died of cancer worldwide last year.
haltak meg 2016-ban.
that we're not on a good road,
to this problem is not working.
nem működik.
a physics-based approach --
fizikára alapozott módszert,
every kind of microbe,
mindenféle mikrobát elpusztítani,
for more than 100 years.
what ultraviolet light is.
mi az ibolyántúli fény.
that includes infrared,
of this group is ultraviolet light.
az ibolyántúli fény.
by a completely different mechanism
más módon öli el a baktériumokat,
of killing a drug-resistant bacteria
öl el rezisztens baktériumokat,
is so good at killing all bugs,
mindenféle baktérium elölésére,
to sterilize rooms,
ultraviolet light.
fénnyel sterilizálnak.
in this picture, actually,
is actually a health hazard,
pl. szürke hályogot okozhat.
germicidal, ultraviolet light
hagyományos, csíraölő ibolyántúli fényt,
amikor emberek is jelen vannak.
when there are people around.
to kill all bacteria,
background kicked into this story.
wavelength of ultraviolet light
ibolyántúli fény,
magas UV-nek vagy FUV-nak nevezzük.
of the ultraviolet spectrum.
is the surface of our skin,
some bacteria in the air above the skin.
néhány baktériumot.
ultraviolet light impinges on this.
ibolyántúli fény gyakorol rájuk hatást.
is really good at killing bacteria,
a baktériumokat,
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
in the air above them.
perfectly fine at killing bacteria,
elölésére továbbra is jó,
is penetrate into our skin.
solid physics reason for that:
absorbed by all biological materials,
a magas UV-fényt,
are really, really, really small,
penetrate them and kill them,
biztosan beléjük hatol, és elöli őket,
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
has been working on
to both these questions
hogy válaszunk mindkét kérdésre
surprised to say that,
of physics at work.
a completely new weapon,
új fegyverünk akadt,
in food preparation areas.
élelmiszer-feldolgozókban.
the spread of viruses,
el tudom képzelni iskolákban,
in airports or airplanes,
reptereken és repülőgépeken,
of viruses like H1N1 virus.
terjedésének meggátlására.
and well-loved local politician
in the center of Liverpool,
a városközpontban.
in this war against superbugs.
baktériumok elleni küzdelemben.
a megoldáshoz.
I've got a question for you.
kérdésem van hozzád.
in developing this,
to trying to roll out
that it kills all bacteria,
UV-fény minden baktériumot elöl,
that before we started,
of tests about safety,
rengeteg tesztre van szükség,
than it is about efficacy.
és már nem a hatékonyság.
melanoma many years on.
nem okoz évek során melanomát.
are pretty well done at this point.
we have to deal with,
a Szövetségi Gyógyszerhivatallal,
in the real world without FDA approval.
nem hasznosíthatjuk a világban.
to launch first in the US,
biologists, doctors,
orvosokat meggyőznötök,
there is a certain skepticism
that UV light is not safe.
hogy az UV-fény nem biztonságos.
we're going to be standing on.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com