Rebecca Brachman: A new class of drug that could prevent depression and PTSD
레베카 브라크만 (Rebecca Brachman): 우울증과 외상 후 스트레스 장애의 예방접종
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
쓰다 남은 것이죠.
one in five soldiers develop depression,
우울증과 외상 후 스트레스 장애로
이해가 되기도 합니다.
that are at high risk for these diseases.
시달리는 것은 아닙니다.
cancer patients, aid workers, refugees --
or major life stress.
다른 이들도 예외가 아닙니다.
these disorders are,
if they work at all,
잘 듣기나 하면 다행이지만
discovered the first vaccine --
천연두 백신을 처음 발견했을 때
a prophylactic for a disease,
한 가지 질병에 대한 예방법이 아니라
뒤집는 아이디어였습니다.
있다는 사실이었죠.
to extend to psychiatric diseases.
확장되지 못했습니다.
accidentally discovered
우울증과 외상 후 스트레스 장애의
depression and PTSD.
whether they work in humans.
보이는지 연구되고 있습니다.
psychopharmaceuticals
stress resilience,
증가시킵니다.
회복력 강화제라고 부르겠습니다.
that you've since recovered from.
힘들었던 시간을 되새겨보세요.
you missed a flight.
비행기를 놓쳤던 때일 수도 있죠.
is the active biological process
활동적인 생체작용입니다.
to bounce back after stress.
이겨낼 수 있게 해주죠.
and your immune system fights it off.
감기를 물리치는 것처럼요.
enough stressor,
such as depression.
갖게 될 수 있습니다.
of major depressive disorder
against purely biological stressors,
순수한 생물학적 스트레스원으로부터
like bullying and isolation.
사회적, 심리적 요인에서도 같습니다.
쥐에게 3주간 투여한 결과입니다.
of stress hormones.
without a psychological component.
생물학적 스트레스만을 준 거죠.
of antidepressant treatment beforehand,
항우울제를 투약했을 때는
enhancer given a week before
단 한 번의 투약만으로도
the depressive behavior.
스트레스 상황을 견뎌냈죠.
a drug has ever been shown
부정적 영향에 효과를 보인
often lifelong, clinical diseases.
만성적이고
될 수도 있는 질병입니다.
of substance abuse, homelessness,
위험도 증가합니다.
is over three trillion dollars per year.
비용이 소모됩니다.
where we know someone is predictively
노출될 위험이 매우 큰 경우를
to extreme stress.
going into an earthquake zone.
지진 발생 지역에 파견된다고 해보죠.
of a resilience enhancer
또는 주사약 하나를
by looters or worse,
혹은 더 안 좋은 상황에서
against developing depression or PTSD
우울증이나 외상 후 스트레스 장애로부터
from experiencing the stress,
자체를 막을 수는 없지만
도움을 줄 수 있습니다.
her susceptibility to depression and PTSD,
민감성을 극적으로 줄일 수 있습니다.
her home, her family or even her life.
심지어 인생을 구할 수도 있습니다.
the smallpox vaccine,
빠르게 뒤를 이었습니다.
was widely available.
sensitive and creative and empathetic.
체질 때문이라고 믿었기 때문입니다.
by constitution and not biology.
today about depression.
비슷한 주장을 하는 사람들이 있습니다.
opened the door
길을 열어준 것처럼
that followed after,
open the possibility of a whole new field:
새로운 영역의 가능성을 열었습니다.
의존되는 문제가 아니라
choose to do with it.
하느냐에 달린 문제입니다.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com