Rebecca Brachman: A new class of drug that could prevent depression and PTSD
Rebecca Brachman: Un nou medicament pentru prevenirea depresiei și sindromului post-traumatic
Rebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness. Full bio
Double-click the English transcript below to play the video.
were made from, of all things,
dintre toate lucrurile posibile,
rămas după al Doilea Război Mondial.
one in five soldiers develop depression,
unul din cinci soldați suferă de depresie
sau de ambele.
that are at high risk for these diseases.
predispuși la aceste boli.
cancer patients, aid workers, refugees --
bolnavii de cancer, voluntarii, refugiații
or major life stress.
cu o traumă sau un stres major.
these disorders are,
aceste boli sunt des întâlnite,
if they work at all,
dacă funcționează,
discovered the first vaccine --
a descoperit primul vaccin,
a prophylactic for a disease,
doar un remediu pentru o boală,
to extend to psychiatric diseases.
nu pot fi prevenite.
accidentally discovered
accidental primele medicamente
depression and PTSD.
și sindromul de stres post-traumatic.
whether they work in humans.
asupra oamenilor.
psychopharmaceuticals
stress resilience,
amplificatori de rezistență.
that you've since recovered from.
pe care l-ați depășit.
you missed a flight.
sau ratarea unui zbor.
is the active biological process
este procesul biologic activ
to bounce back after stress.
după o perioadă stresantă.
and your immune system fights it off.
imunitar încearcă să te apere.
cu un eveniment stresant,
enough stressor,
precum depresia.
such as depression.
de depresie severă
of major depressive disorder
de factori de stres pur biologici,
against purely biological stressors,
like bullying and isolation.
precum hărțuirea și izolarea.
în care am administrat unor șoareci
timp de trei săptămâni.
of stress hormones.
without a psychological component.
fără componentă psihologică.
of antidepressant treatment beforehand,
trei săptămâni în prealabil,
enhancer given a week before
administrată cu o săptămână înainte,
the depressive behavior.
a drug has ever been shown
că un medicament
efectele negative ale stresului.
post-traumatic sunt boli cronice,
often lifelong, clinical diseases.
of substance abuse, homelessness,
pentru abuzul de substanțe,
Alzheimer și suicid.
is over three trillion dollars per year.
de dolari doar pe tratarea depresiei.
where we know someone is predictively
în care știm deja că cineva
to extreme stress.
de la Crucea Roșie care merge
going into an earthquake zone.
of a resilience enhancer
sau să-i facem o injecție
înainte să plece.
cu arma de hoți sau poate și mai rău,
by looters or worse,
against developing depression or PTSD
sau de sindromul de stres post-traumatic
from experiencing the stress,
her susceptibility to depression and PTSD,
și sindrom de stres post-traumatic
casa, familia sau chiar viața.
her home, her family or even her life.
the smallpox vaccine,
vaccinul pentru variolă,
de 150 de ani până am început
was widely available.
împotriva tuberculozei.
sensitive and creative and empathetic.
mai sensibili, creativi și empatici.
by constitution and not biology.
nu de bacterii.
today about depression.
spuse și astăzi despre depresie.
opened the door
un deschizător de drumuri
that followed after,
open the possibility of a whole new field:
pot deschide calea unui alt domeniu:
alegem să facem.
choose to do with it.
ABOUT THE SPEAKER
Rebecca Brachman - Neuroscientist, writer, entrepreneurRebecca Brachman is a pioneer in the field of preventative psychopharmacology, developing drugs to enhance stress resilience and prevent mental illness.
Why you should listen
Current treatments for mood disorders only suppress symptoms without addressing the underlying disease, and there are no known cures. The drugs Rebecca Brachman is developing would be the first to prevent psychiatric disorders such as post-traumatic stress disorder (PTSD) and depression.
Brachman completed her PhD at Columbia University, prior to which she was a fellow at the National Institutes of Health, where she discovered that immune cells carry a memory of psychological stress and that white blood cells can act as antidepressants and resilience-enhancers. Brachman's research has been featured in The Atlantic, WIRED and Business Insider, and her work was recently described by Dr. George Slavich on NPR as a "moonshot project that is very much needed in the mental health arena."
In addition to conducting ongoing research at Columbia, Brachman is an NYCEDC Entrepreneurship Lab Fellow and cofounder of Paravax -- a biotech startup developing vaccine-like prophylactic drugs ("paravaccines") -- along with her scientific collaborator, Christine Ann Denny. She is also working on a non-profit venture to repurpose existing generic drugs for use as prophylactics, and previously served as the Interim Program Director for Outreach at the Zuckerman Institute at Columbia University.
Brachman is also a playwright and screenwriter. She holds Bachelor's degrees in both neuroscience and creative wWriting, and she is currently working on a tech-focused writing project with her long-time writing partner, Sean Calder ("Grimm," "Damages," "ER"). She served as the director of NeuWrite, a national network of science-writing groups that fosters ongoing collaboration between scientists, writers and artists, and she has been featured as a storyteller at The Story Collider.
(Photo: Kenneth Willardt)
Rebecca Brachman | Speaker | TED.com