Faith Osier: The key to a better malaria vaccine
فايذ أوسير: المفتاح للقاح ملاريا أفضل
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
about malaria vaccines.
are simply not good enough.
ببساطة لم تكن جيدة.
for 100 plus years.
of what the parasite really looked like.
من شكل الطفيل الحقيقي
the parasite really is.
has remained pretty rudimentary.
we must go back to basics
علينا الرجوع إلى الأساسيات
handle this complexity.
infected with malaria
but they don't get ill.
who had overcome malaria
تغلبوا على الملاريا
antibody response look like?"
للأجسام المضادة؟"
on the radar for malaria vaccines.
في كاشوف لقاحات الملاريا
important parts of the parasite.
أجزاء مهمة من الطفيلي
a protein of interest,
عن بروتين ذو أهمية
important for a vaccine
participants in a village in Africa,
من قرية في أفريقيا
would predict who got malaria
تستطيع التنبؤ بمن أصيب بالملاريا
a small number of proteins
صغيرة من البروتينات
30 years of this type of research
30 عاماً من هذا النوع من الأبحاث
conducted over just three months.
أجريت في ثلاثة شهور فقط
in seven African countries,
and the variable intensity
to prioritize our parasite proteins,
أولويات بروتينات الطفيلي
the malaria parasite on a chip.
طفيلي الملاريا على رقاقة.
and we're very proud of that.
ونحن فخورون بذلك جداً.
on over 100 antibody responses.
استجابة جسم مضاد في آن واحد
antibody response,
الناجحة للأجسام المضادة
what might make a good malaria vaccine.
يصنع لقاح ملاريا جيد.
do to the parasite.
Is there synergy?
a bit of one antibody won't be enough.
مضاد لن يكون كافيًا.
concentrations of antibodies
من الأجسام المضادة
kill the parasite in multiple ways,
تقتل الطفيلي بطرق متعددة،
may not adequately reflect reality.
العزل قد لا يعكس الواقع بشكل كافي.
in greater definition,
الطفيلي بوضوح أفضل
overcome this complexity.
أجسادنا على هذا التعقيد.
the breakthroughs that we need
الاختراقات التي نحتاجها
through vaccination.
are we actually to a malaria vaccine?
الفعلي من لقاح الملاريا؟
at the beginning of a process
what we need to put in the vaccine
but we're getting there.
لكننا سنصل الى ذلك.
tell me what does it stand for
أخبريني إلى ماذا يرمز
Malaria Antigen Research Partnership.
شراكة بحث مستضد الملاريا
is referring to us in Africa,
in collaboration,
and looking to Europe,
some strength within Africa.
to develop a malaria vaccine,
الذي هو تطوير لقاح للملاريا،
of disease in Africa is high,
to push the boundaries
سيستمرون في توسيع نطاقات
mentioned this a little bit,
if there were a malaria vaccine?
كان هناك تطعيم للملاريا؟
half a million lives every year.
مليون حياة كل عام،
12 billion US dollars a year.
أفريقيا 12 مليار دولار أمريكي كل عام
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com