Faith Osier: The key to a better malaria vaccine
फेथ ओसीयर: बेहतर मलेरिया टीका बनाने की कुंजी।
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
फाल्सीपेरम मलेरिया के,
about malaria vaccines.
आपसे बात करना चाहती हूं।
are simply not good enough.
वे बस पर्याप्त नहीं हैं।
for 100 plus years.
इस पर काम कर रहे हैं।
तंत्रज्ञान काफी सीमित था ।
of what the parasite really looked like.
हम केवल एक छोटा सा अंश देख सकते थे।
the parasite really is.
has remained pretty rudimentary.
बहुत प्राथमिक रहा है।
we must go back to basics
हमें मूल बातें फिर से जाननी चाहिए
handle this complexity.
इस जटिलता को कैसे संभालेंगे।
infected with malaria
अक्सर संक्रमित होते हैं
but they don't get ill.
लेकिन वे बीमार नहीं होते हैं।
who had overcome malaria
मलेरिया से उबरने वाले अफ्रीकी लोगों के
antibody response look like?"
कैसा दिखता है?"
on the radar for malaria vaccines.
टीके रडार पर नहीं हैं।
important parts of the parasite.
हिस्सों को याद कर सकता है।
a protein of interest,
अलग करके पहचान की थी,
important for a vaccine
टीका के लिए समूह अध्यन आयोजित
participants in a village in Africa,
लगभग 300 प्रतिभागियों को शामिल करता था,
विश्लेषण किया गया था
would predict who got malaria
भविष्यवाणी करेंगे कि मलेरिया किसे होगा
a small number of proteins
एक छोटी संख्या का परीक्षण किया है
30 years of this type of research
प्रयोग को एक रोमांचक रूप से ध्वस्त कर दिया,
conducted over just three months.
in seven African countries,
and the variable intensity
और मलेरिया की परिवर्तनीय
to prioritize our parasite proteins,
प्राथमिकता देने के लिए
the malaria parasite on a chip.
परजीवी को फिर से बनाया।
and we're very proud of that.
और हमें उस पर बहुत गर्व है।
on over 100 antibody responses.
प्रतिक्रियाओं पर डेटा इकट्ठा किया।
antibody response,
what might make a good malaria vaccine.
अच्छी मलेरिया टीका क्या हो सकती है।
do to the parasite.
एंटीबॉडी क्या करते हैं।
Is there synergy?
क्या कोई तालमेल है?
a bit of one antibody won't be enough.
concentrations of antibodies
प्रोटीन के खिलाफ
kill the parasite in multiple ways,
परजीवी को कई तरीकों से मार देते हैं,
may not adequately reflect reality.
प्रतिबिंबित नहीं कर सकता है।
in greater definition,
स्पष्टता से देख सकते हैं,
overcome this complexity.
जटिलता को कैसे दूर कर सकती हैं।
the breakthroughs that we need
आवश्यक सफलताएं मिल सकती हैं
through vaccination.
इतिहास बनाने की आवश्यकता है।
are we actually to a malaria vaccine?
मलेरिया टीका के करीब कितने करीब हैं?
at the beginning of a process
प्रक्रिया की शुरुआत में हैं
what we need to put in the vaccine
हमें टीका में क्या रखना है
में इसे बनाना शुरू करें।
but we're getting there.
हैं, लेकिन हम वहां जा रहे हैं।
tell me what does it stand for
बताओ कि इसका क्या मतलब है
Malaria Antigen Research Partnership.
मलेरिया एंटीजन अनुसंधान साझेदारी है।
is referring to us in Africa,
हमें जिक्र कर रहा है,
in collaboration,
लिए बगल में देख रहे हैं,
and looking to Europe,
और यूरोप की तलाश में,
some strength within Africa.
to develop a malaria vaccine,
मलेरिया टीका विकसित करने के,
को भी प्रशिक्षण दे रहे हैं,
of disease in Africa is high,
का बोझ काफी ज़्यादा है,
to push the boundaries
सीमाओं को आगे बढ़ाना जारी रखेंगे
mentioned this a little bit,
आपने इसका थोड़ा सा उल्लेख किया है,
if there were a malaria vaccine?
चीजें वास्तव में कैसे बदलेगी?
half a million lives every year.
12 billion US dollars a year.
अफ्रीका 12 अरब अमेरिकी डॉलर खर्च होता है।
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com