Faith Osier: The key to a better malaria vaccine
Faith Osier: Klucz do lepszej szczepionki na malarię
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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200 milionów zachorowań
in Africa every year,
to przypadki śmiertelne.
about malaria vaccines.
o szczepionkach na malarię.
are simply not good enough.
nie są zadowalające.
for 100 plus years.
of what the parasite really looked like.
nauk "omnicznych" ,
transkryptomiki czy proteomiki.
the parasite really is.
do tworzenia szczepionek
has remained pretty rudimentary.
we must go back to basics
żeby stworzyć dobrą szczepionkę,
z czymś tak złożonym.
handle this complexity.
infected with malaria
but they don't get ill.
tym złożonym pasożytem,
od Afrykańczyków, którzy pokonali malarię,
who had overcome malaria
reakcja immunologiczna?".
antibody response look like?"
przy szczepionce na malarię.
on the radar for malaria vaccines.
important parts of the parasite.
być może pomija ważne części pasożyta.
a protein of interest,
jeśli odkryto znaczące białko,
important for a vaccine
participants in a village in Africa,
300 uczestników z jednej wioski w Afryce,
w odpowiedzi na dane białko,
would predict who got malaria
niewielką liczbę białek
a small number of proteins
30 years of this type of research
przeprowadzony w ciągu trzech miesięcy.
conducted over just three months.
zebraliśmy 10 000 próbek
in seven African countries,
and the variable intensity
występowania malarii w Afryce.
to prioritize our parasite proteins,
żeby skupić się na białkach pasożyta,
pasożyta malarii na chipie.
the malaria parasite on a chip.
and we're very proud of that.
z czego jesteśmy bardzo dumni.
on over 100 antibody responses.
ponad 100 reakcji immunologicznych.
antibody response,
what might make a good malaria vaccine.
do to the parasite.
Występuje synergia?
Is there synergy?
a bit of one antibody won't be enough.
ilość jednego przeciwciała nie wystarczy.
concentrations of antibodies
przeciwko kilku różnym białkom pasożyta.
kill the parasite in multiple ways,
zabijają pasożyta na kilka sposobów.
może prowadzić do nieadekwatnych wyników.
may not adequately reflect reality.
in greater definition,
skupiamy się na tym,
overcome this complexity.
radzi sobie z czymś tak złożonym.
the breakthroughs that we need
skutecznej szczepionki przeciw malarii.
through vaccination.
are we actually to a malaria vaccine?
at the beginning of a process
czego potrzeba do jej wytworzenia,
what we need to put in the vaccine
but we're getting there.
ale zmierzamy w tym kierunku.
tell me what does it stand for
Malaria Antigen Research Partnership.
Malaria Antigen Research Partnership.
is referring to us in Africa,
in collaboration,
w stronę Ameryki i Europy,
and looking to Europe,
some strength within Africa.
stworzenia szczepionki przeciw malarii,
to develop a malaria vaccine,
of disease in Africa is high,
którzy będą rozwijali naukę w Afryce.
to push the boundaries
mentioned this a little bit,
gdyby istniała szczepionka na malarię.
if there were a malaria vaccine?
half a million lives every year.
pół miliona ludzi rocznie,
na malarię 12 miliardów dolarów rocznie.
12 billion US dollars a year.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com