Faith Osier: The key to a better malaria vaccine
פיית' אוזייר: המפתח לחיסון טוב יותר למלריה
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
about malaria vaccines.
are simply not good enough.
for 100 plus years.
of what the parasite really looked like.
של הטפיל הגורם למחלה.
וחקר מולקולות ביולוגיות מתקדמים -
the parasite really is.
has remained pretty rudimentary.
נותרה בסיסית למדי.
we must go back to basics
עלינו לחזור ליסודות
handle this complexity.
מתמודד עם המורכבות הזו.
infected with malaria
but they don't get ill.
who had overcome malaria
מאפריקאים שהתגברו על המלריה
antibody response look like?"
on the radar for malaria vaccines.
כאפשרות ליצירת חיסונים למלריה.
important parts of the parasite.
החמיצה חלקים חשובים של הטפיל.
a protein of interest,
important for a vaccine
participants in a village in Africa,
would predict who got malaria
מנבאת מי ידבק במלריה
a small number of proteins
30 years of this type of research
conducted over just three months.
שנמשך מעט יותר משלושה חודשים.
in seven African countries,
and the variable intensity
ובדרגות החומרה השונות
to prioritize our parasite proteins,
כדי לתעדף חלבונים טפיליים,
the malaria parasite on a chip.
and we're very proud of that.
on over 100 antibody responses.
על למעלה מ-100 תגובות נוגדניות.
antibody response,
what might make a good malaria vaccine.
חיסון מוצלח למלריה.
do to the parasite.
Is there synergy?
האם יש תיאום ביניהם?
a bit of one antibody won't be enough.
של נוגדן אחד בגוף לא מספיקה.
concentrations of antibodies
kill the parasite in multiple ways,
במגוון דרכים,
may not adequately reflect reality.
עלולה לא לשקף את המציאות כראוי.
in greater definition,
ביתר בירור כעת,
overcome this complexity.
מתגבר על המורכבות הזו.
the breakthroughs that we need
את פריצת הדרך לה אנו זקוקים
through vaccination.
בעזרת חיסונים אפקטיביים.
are we actually to a malaria vaccine?
לפיתוח חיסון למלריה?
at the beginning of a process
what we need to put in the vaccine
but we're getting there.
של יצירת חיסון, אבל אנחנו בדרך.
tell me what does it stand for
Malaria Antigen Research Partnership.
שותפות מחקר באנטיגן למלריה דרום-דרום.
is referring to us in Africa,
in collaboration,
ומשתפים פעולה,
and looking to Europe,
יפתרו את הבעיה,
some strength within Africa.
to develop a malaria vaccine,
לפתח חיסון למלריה,
of disease in Africa is high,
to push the boundaries
mentioned this a little bit,
אני יודע שהזכרת את זה קודם,
if there were a malaria vaccine?
half a million lives every year.
12 billion US dollars a year.
12 מיליארד דולר כל שנה.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com