Faith Osier: The key to a better malaria vaccine
Фејт Осије (Faith Osier): Кључ за бољу вакцину против маларије
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
Double-click the English transcript below to play the video.
клиничких случајева
in Africa every year,
пола милиона смртних случајева.
about malaria vaccines.
о вакцинама против маларије.
are simply not good enough.
једноставно нису довољно добре.
for 100 plus years.
технологија је била ограничена.
of what the parasite really looked like.
стварног изгледа паразита.
наука са суфиксом -омика:
да јасније видимо
the parasite really is.
has remained pretty rudimentary.
остао је прилично неразвијен.
we must go back to basics
морамо се вратити основама
handle this complexity.
излази на крај са овом сложеношћу.
infected with malaria
but they don't get ill.
на нашег сложеног паразита
who had overcome malaria
од Африканаца који су пребродили маларију
antibody response look like?"
on the radar for malaria vaccines.
за вакцине против маларије.
important parts of the parasite.
можда пропушта важне делове паразита.
a protein of interest,
идентификовао протеин од значаја,
important for a vaccine
бити важно за вакцину
participants in a village in Africa,
око 300 учесника у једном селу у Африци,
would predict who got malaria
могла предвидети ко је добио маларију,
a small number of proteins
мали број протеина
30 years of this type of research
30 година ове врсте истраживања
conducted over just three months.
спроведен за само три месеца.
in seven African countries,
and the variable intensity
и променљиви интензитет
to prioritize our parasite proteins,
да приоритетизујемо протеине паразита,
the malaria parasite on a chip.
паразит маларије на чипу.
and we're very proud of that.
и веома смо поносни на то.
on over 100 antibody responses.
о преко 100 реакција антитела.
antibody response,
what might make a good malaria vaccine.
чинити добру вакцину против маларије.
do to the parasite.
Is there synergy?
Да ли постоји синергија?
a bit of one antibody won't be enough.
имати мало једне врсте антитела.
concentrations of antibodies
високе концентрације антитела
kill the parasite in multiple ways,
убијају паразита на више начина,
may not adequately reflect reality.
одражавати стварност.
in greater definition,
у бољој дефиницији,
overcome this complexity.
превазилазе ову сложеност.
the breakthroughs that we need
напретке који су нам потребни
through vaccination.
постане прошлост путем вакцинације.
are we actually to a malaria vaccine?
вакцини против маларије?
at the beginning of a process
what we need to put in the vaccine
шта треба да ставимо у вакцину
да је правимо.
but we're getting there.
али стижемо тамо.
tell me what does it stand for
реците ми за шта значи
Malaria Antigen Research Partnership.
за истраживање антигена маларије.
is referring to us in Africa,
in collaboration,
and looking to Europe,
у Америку и Европу,
some strength within Africa.
to develop a malaria vaccine,
развоја вакцине против маларије,
of disease in Africa is high,
to push the boundaries
који ће наставити да померају границе
mentioned this a little bit,
if there were a malaria vaccine?
када би постојала вакцина против маларије?
пола милиона живота.
half a million lives every year.
12 billion US dollars a year.
12 милијарди америчких долара годишње.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com