Faith Osier: The key to a better malaria vaccine
Faith Osier: La chiave per un miglior vaccino contro la malaria
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
ogni anno in Africa,
about malaria vaccines.
vaccini per la malaria.
are simply not good enough.
non sono abbastanza efficaci.
for 100 plus years.
le tecnologie erano limitate.
of what the parasite really looked like.
di come appariva il parassita.
di avere una visione più chiara
the parasite really is.
del vaccino è rimasto rudimentale.
has remained pretty rudimentary.
we must go back to basics
dobbiamo ritornare alle basi
handle this complexity.
reagiscono a questa complessità.
infected with malaria
dalla malaria frequentemente
but they don't get ill.
a quel nostro complesso parassita,
che sono sopravvissuti alla malaria
who had overcome malaria
antibody response look like?"
on the radar for malaria vaccines.
per il vaccino della malaria.
important parts of the parasite.
considera parti importanti del parassita.
a protein of interest,
identificato una proteina interessante,
important for a vaccine
importante per il vaccino
participants in a village in Africa,
di un villaggio africano,
i loro campioni per vedere
would predict who got malaria
potessero predire chi aveva la malaria
a small number of proteins
un numero esiguo di proteine
30 anni di questo tipo di ricerca
30 years of this type of research
condotto in appena tre mesi.
conducted over just three months.
abbiamo raccolto 10.000 campioni
in seven African countries,
in sette stati africani,
and the variable intensity
to prioritize our parasite proteins,
privilegiato le proteine del parassita,
the malaria parasite on a chip.
il parassita della malaria.
and we're very proud of that.
e ne siamo molto fieri.
on over 100 antibody responses.
da più di 100 risposte anticorpali.
antibody response,
anticorpale efficace,
what might make a good malaria vaccine.
un buon vaccino per la malaria.
do to the parasite.
gli anticorpi al parassita.
Is there synergy?
C'è una sinergia?
a bit of one antibody won't be enough.
un po' di alcuni anticorpi non serve.
concentrations of antibodies
alte concentrazioni di anticorpi
uccidono il parassita in diversi modi,
kill the parasite in multiple ways,
may not adequately reflect reality.
potrebbe non riflettere la realtà.
con maggiore definizione,
in greater definition,
overcome this complexity.
a superare questa complessità.
the breakthroughs that we need
la svolta di cui abbiamo bisogno
through vaccination.
attraverso il vaccino.
ad un vaccino per la malaria?
are we actually to a malaria vaccine?
all'inizio di un processo
at the beginning of a process
what we need to put in the vaccine
dobbiamo mettere nel vaccino
but we're getting there.
ma andiamo in quella direzione.
che cosa significa
tell me what does it stand for
Malaria Antigen Research Partnership.
Malaria Antigen Research Partnership."
is referring to us in Africa,
a noi in Africa,
in collaboration,
all'America o all'Europa,
and looking to Europe,
some strength within Africa.
to develop a malaria vaccine,
di sviluppare un vaccino antimalarico,
of disease in Africa is high,
in Africa è elevato,
to push the boundaries
allargare i confini
mentioned this a little bit,
già menzionato un po',
if there were a malaria vaccine?
se ci fosse un vaccino per la malaria?
mezzo milione di vite ogni anno.
half a million lives every year.
12 billion US dollars a year.
12 miliardi di dollari all'anno.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com