Faith Osier: The key to a better malaria vaccine
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
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in Africa every year,
about malaria vaccines.
are simply not good enough.
for 100 plus years.
of what the parasite really looked like.
the parasite really is.
has remained pretty rudimentary.
we must go back to basics
handle this complexity.
infected with malaria
but they don't get ill.
who had overcome malaria
antibody response look like?"
on the radar for malaria vaccines.
important parts of the parasite.
a protein of interest,
important for a vaccine
participants in a village in Africa,
would predict who got malaria
a small number of proteins
30 years of this type of research
conducted over just three months.
in seven African countries,
and the variable intensity
to prioritize our parasite proteins,
the malaria parasite on a chip.
and we're very proud of that.
on over 100 antibody responses.
antibody response,
what might make a good malaria vaccine.
do to the parasite.
Is there synergy?
a bit of one antibody won't be enough.
concentrations of antibodies
kill the parasite in multiple ways,
may not adequately reflect reality.
in greater definition,
overcome this complexity.
the breakthroughs that we need
through vaccination.
are we actually to a malaria vaccine?
at the beginning of a process
what we need to put in the vaccine
but we're getting there.
tell me what does it stand for
Malaria Antigen Research Partnership.
is referring to us in Africa,
in collaboration,
and looking to Europe,
some strength within Africa.
to develop a malaria vaccine,
of disease in Africa is high,
to push the boundaries
mentioned this a little bit,
if there were a malaria vaccine?
half a million lives every year.
12 billion US dollars a year.
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com