David Brenner: A new weapon in the fight against superbugs
دیوید برنر: سلاحی جدید در مبارزه با ابرباکتریها
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
در جنگ واقعی هستیم،
at the moment,
of some soccer fans --
هوادار فوتبال نشان شما میدهم --
celebrating a famous victory
جشن پیروزی بازی مهمی هستند
that's my friend Paul Rice.
دوست من پال رایس هست،
after this picture was taken,
for some minor surgery,
a superbug-related infection,
ابرباکتری در او گسترش یافت،
دوران زندگیاش بود.
from a couple of TEDsters,
personal war on superbugs.
for a moment.
ابرباکتریها حرف بزنیم.
introduction of antibiotics.
have continued to emerge,
در حال پدیدار شدن هستند،
newer and newer drugs
و پیشرفتهتری تولید کنیم
actually is the origin of superbugs,
آغاز ابرباکتریها است،
for which we don't have effective drugs.
at least some of these superbugs.
از این ابرباکتریها آشنایی دارید.
common ones around today.
نفر جان خود را از دست دادند
approach to the problem,
by the middle of this century
from superbugs will be 10 million.
به ۱۰ میلیون خواهد رسید.
that's actually more
that died of cancer worldwide last year.
در سال گذشته هم بیشتر بوده است.
that we're not on a good road,
که در مسیر درستی نیستیم،
to this problem is not working.
a physics-based approach --
مبتنی بر فیزیک پیش بگیریم --
every kind of microbe,
هر نوع میکروبی را میدانیم،
for more than 100 years.
what ultraviolet light is.
نور فرابنفش چیست.
that includes infrared,
که امواج فروسرخ را شامل میشود،
of this group is ultraviolet light.
طول موج کمتری دارد.
by a completely different mechanism
کاملاً متفاوتی باکتریها را میکشد
of killing a drug-resistant bacteria
باکتری مقاوم بر دارو را بکشد
is so good at killing all bugs,
هر نوع میکروبی خوب عمل میکند،
to sterilize rooms,
در ضد عفونی کردن اتاقها،
ultraviolet light.
نور فرابنفش باکتریکُش.
in this picture, actually,
is actually a health hazard,
برای سلامت بسیار خطرناک است،
ما آسیب برساند،
آبمروارید میشود،
germicidal, ultraviolet light
میکروب کش، معمولی استفاده کنید
when there are people around.
میکروب کشی کنیم آدمها هستند.
to kill all bacteria,
در معرض آن قرار بگیرند.
background kicked into this story.
علم فیزیک من به کار آمد.
wavelength of ultraviolet light
فرابنفش دور (far-UVC) است،
of the ultraviolet spectrum.
is the surface of our skin,
some bacteria in the air above the skin.
ultraviolet light impinges on this.
معمولی به آن برخورد میکند.
is really good at killing bacteria,
در کشتن باکتریها خوب عمل میکند،
into the upper layers of our skin,
those key cells in our skin
مهم پوستمان آسیب بزند
can lead to skin cancer.
میتواند منجر به سرطان شود.
مقایسه میکنیم--
in the air above them.
perfectly fine at killing bacteria,
در کشتن باکتریها عالی عمل میکند،
is penetrate into our skin.
به پوست نفوذ کند.
solid physics reason for that:
absorbed by all biological materials,
توسط تمام مواد زیستی جذب میشود،
are really, really, really small,
خیلی، خیلی، خیلی کوچکاند،
penetrate them and kill them,
میتواند به آنها نفوذ کرده آنان را بکشد،
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
باکتریها را بکشد،
has been working on
مشغول کار بوده است
to both these questions
surprised to say that,
of physics at work.
a completely new weapon,
سلاح کاملاً جدیدی داریم،
فرابنفش-دور میبینم،
in food preparation areas.
فرابنفش-دور میبینم.
the spread of viruses,
in airports or airplanes,
فرابنفش-دور میبینم،
of viruses like H1N1 virus.
ویروسهایی مانند آنفولانزای خوکی.
and well-loved local politician
و شناخته شدهای بود
in the center of Liverpool,
برای یادبود او گذاشتند،
in this war against superbugs.
در مبارزه با ابرباکتریها باشد.
I've got a question for you.
ازت سوال دارم.
in developing this,
از این پروسه هستی،
to trying to roll out
که همهٔ باکتریها را میکشد،
that it kills all bacteria,
از اینکه شروع کنیم میدانستیم،
that before we started,
of tests about safety,
آزمایشهای زیادی انجام دهیم،
than it is about efficacy.
melanoma many years on.
سرطان پوست نمیشود.
are pretty well done at this point.
به خوبی انجام شده است.
we have to deal with,
سروکار خواهیم داشت
in the real world without FDA approval.
نمیتوانیم از این استفاده کنیم.
to launch first in the US,
آزمایش را در آمریکا شروع کنید،
biologists, doctors,
زیست شناسان را متقاعد کنید،
there is a certain skepticism
تصور کنید تردیدهایی هست
that UV light is not safe.
we're going to be standing on.
به اشتراک گذاشتید.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com