David Brenner: A new weapon in the fight against superbugs
大卫·布伦纳: 对抗超级细菌的新武器
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
一场真实的战争,
of some soccer fans --
一张都是足球迷的照片——
celebrating a famous victory
在庆祝一场著名的胜利 ,
that's my friend Paul Rice.
是我的朋友保罗·赖斯。
after this picture was taken,
for some minor surgery,
a superbug-related infection,
from a couple of TEDsters,
personal war on superbugs.
for a moment.
实际上开始于1940年代,
introduction of antibiotics.
have continued to emerge,
newer and newer drugs
actually is the origin of superbugs,
超级细菌的起源,
for which we don't have effective drugs.
可以与之对抗的细菌。
at least some of these superbugs.
某些细菌有印象。
common ones around today.
approach to the problem,
by the middle of this century
from superbugs will be 10 million.
将达到1000万。
that's actually more
没什么概念的话,这实际上比
that died of cancer worldwide last year.
死于癌症的人数还要多。
that we're not on a good road,
在一条正确的路上,
to this problem is not working.
a physics-based approach --
采用一种基于物理学的方法——
every kind of microbe,
如何杀死每一种微生物,
for more than 100 years.
我们就知道了这一点。
what ultraviolet light is.
that includes infrared,
of this group is ultraviolet light.
by a completely different mechanism
of killing a drug-resistant bacteria
is so good at killing all bugs,
to sterilize rooms,
比如消毒房间,
ultraviolet light.
in this picture, actually,
is actually a health hazard,
germicidal, ultraviolet light
when there are people around.
我们也想要消毒。
to kill all bacteria,
background kicked into this story.
能够发挥作用的地方。
wavelength of ultraviolet light
of the ultraviolet spectrum.
is the surface of our skin,
some bacteria in the air above the skin.
在皮肤表面的空气中。
ultraviolet light impinges on this.
紫外线中会发生什么。
is really good at killing bacteria,
确实对细菌有很强杀伤力,
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
可能会引起皮肤癌。
远—短波紫外线——
in the air above them.
perfectly fine at killing bacteria,
完美地杀死了细菌,
is penetrate into our skin.
不能穿入我们的皮肤。
solid physics reason for that:
absorbed by all biological materials,
能够被所有的生物材料强烈吸收,
are really, really, really small,
penetrate them and kill them,
能够穿透并杀死它们,
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
has been working on
to both these questions
surprised to say that,
我并不感到惊讶,
of physics at work.
物理学的规律在起作用。
a completely new weapon,
现在我们有了一种全新的武器,
in food preparation areas.
有远—短波紫外线。
the spread of viruses,
in airports or airplanes,
有远—短波紫外线,
of viruses like H1N1 virus.
那样的病毒在全球传播。
and well-loved local politician
他是一位人尽皆知
in the center of Liverpool,
建了一座雕塑纪念他,
in this war against superbugs.
超级细菌的战争中出现一个巨大的进步。
I've got a question for you.
等等,大卫,我有一个问题要问你。
in developing this,
to trying to roll out
that it kills all bacteria,
我们现在知道了它能够杀死所有细菌,
that before we started,
of tests about safety,
关于它的安全性的测试,
than it is about efficacy.
melanoma many years on.
are pretty well done at this point.
we have to deal with,
食品药品监督管理局(FDA)的许可,
in the real world without FDA approval.
FDA的许可之下投入使用。
to launch first in the US,
不只是美国,
biologists, doctors,
你有说服过生物学家、医生,
there is a certain skepticism
你也知道确实存在某种怀疑,
that UV light is not safe.
we're going to be standing on.
好的,我们希望你能成功。
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com