David Brenner: A new weapon in the fight against superbugs
David Brenner: Uma nova arma na guerra contra as superbactérias
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
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at the moment,
of some soccer fans --
uma foto de fãs de futebol?
celebrating a famous victory
a festejar uma famosa vitória
that's my friend Paul Rice.
o meu amigo Paul Rice.
after this picture was taken,
for some minor surgery,
para uma pequena cirurgia,
a superbug-related infection,
por uma superbactéria
from a couple of TEDsters,
por parte de alguns TEDsters,
personal war on superbugs.
às superbactérias.
for a moment.
introduction of antibiotics.
have continued to emerge,
resistentes aos medicamentos
newer and newer drugs
cada vez mais medicamentos
actually is the origin of superbugs,
da origem das superbactérias
for which we don't have effective drugs.
não temos medicamentos eficazes.
at least some of these superbugs.
que reconhecerão algumas delas.
common ones around today.
cerca de 700 000 pessoas
causadas por superbactérias.
approach to the problem,
ao problema, baseada nos medicamentos,
by the middle of this century
from superbugs will be 10 million.
vai ser de 10 milhões.
that's actually more
that died of cancer worldwide last year.
no mundo, no ano passado.
that we're not on a good road,
que não estamos num bom caminho,
to this problem is not working.
não está a funcionar.
a physics-based approach --
adotar uma abordagem baseada na física,
a primeira certeza que temos
every kind of microbe,
cada tipo de micróbio,
for more than 100 years.
há mais de 100 anos.
what ultraviolet light is.
o que é a luz ultravioleta.
that includes infrared,
que inclui a luz infravermelha,
of this group is ultraviolet light.
deste comprimento de onda é a luz UV.
by a completely different mechanism
de maneira completamente diferente
of killing a drug-resistant bacteria
resistentes aos medicamentos
is so good at killing all bugs,
para matar as bactérias,
to sterilize rooms,
para esterilizar quartos,
ultraviolet light.
in this picture, actually,
is actually a health hazard,
como as cataratas.
germicidal, ultraviolet light
convencional, germicida,
when there are people around.
quando há pessoas à volta.
to kill all bacteria,
para a exposição de seres humanos.
background kicked into this story.
se torna relevante.
wavelength of ultraviolet light
comprimento de onda UV
de seres humanos.
é a luz ultravioleta C,
of the ultraviolet spectrum.
do espetro UV.
is the surface of our skin,
some bacteria in the air above the skin.
no ar acima da pele.
ultraviolet light impinges on this.
e germicida incide na pele.
is really good at killing bacteria,
funciona bem para matar bactérias.
into the upper layers of our skin,
superiores da pele,
those key cells in our skin
can lead to skin cancer.
podem causar cancro da pele.
com luz ultravioleta C.
in the air above them.
perfectly fine at killing bacteria,
para matar todas as bactérias
is penetrate into our skin.
solid physics reason for that:
absorbed by all biological materials,
por qualquer material biológico,
are really, really, really small,
penetrate them and kill them,
pode atravessá-los e matá-los,
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
has been working on
a trabalhar nisto
to both these questions
que a resposta a estas perguntas
surprised to say that,
of physics at work.
da física a funcionar.
a completely new weapon,
uma arma completamente nova,
in food preparation areas.
de preparação de comida.
the spread of viruses,
in airports or airplanes,
of viruses like H1N1 virus.
como o H1N1.
and well-loved local politician
conhecido e apreciado
minha e dele.
in the center of Liverpool,
em sua memória no centro de Liverpool.
in this war against superbugs.
avanço na guerra contra as superbactérias.
I've got a question for you.
tenho uma pergunta para ti.
in developing this,
está o desenvolvimento disso
to trying to roll out
para o seu lançamento
that it kills all bacteria,
que mata todas as bactérias
that before we started,
of tests about safety,
than it is about efficacy.
do que na eficácia.
melanoma many years on.
desenvolver melanomas nos anos a seguir.
are pretty well done at this point.
nesta altura, já estão feitos.
we have to deal with,
in the real world without FDA approval.
sem a aprovação da FDA.
to launch first in the US,
primeiro nos EUA
biologists, doctors,
biólogos, médicos,
there is a certain skepticism
há algum ceticismo
that UV light is not safe.
que a luz UV não é segura.
we're going to be standing on.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com