David Brenner: A new weapon in the fight against superbugs
David Brenner: Une nouvelle arme dans la lutte contre les superbactéries
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
engagés dans une vraie guerre,
de superbactéries,
of some soccer fans --
de supporters de football –
celebrating a famous victory
fêtant une grande victoire,
that's my friend Paul Rice.
c'est mon ami Paul Rice.
after this picture was taken,
for some minor surgery,
intervention chirurgicale mineure.
a superbug-related infection,
liée à une superbactérie
dans la fleur de l'âge.
from a couple of TEDsters,
de plusieurs membres de TED,
personal war on superbugs.
guerre aux superbactéries.
for a moment.
dans les années 40,
introduction of antibiotics.
des antibiotiques.
have continued to emerge,
n'ont pas cessé d'apparaître
newer and newer drugs
et encore de nouveaux médicaments
actually is the origin of superbugs,
à l'origine des superbactéries,
for which we don't have effective drugs.
il n'y a pas de remède efficace.
at least some of these superbugs.
certaines de ces superbactéries.
common ones around today.
sont mortes, l'année dernière [en 2016],
approach to the problem,
by the middle of this century
nous dit qu'en 2050
from superbugs will be 10 million.
à cause des superbactéries.
that's actually more
that died of cancer worldwide last year.
au cancer l'année dernière.
that we're not on a good road,
sommes pas sur la bonne voie
to this problem is not working.
les médicaments, ne fonctionne pas.
a physics-based approach --
trouver une solution liée à la physique,
every kind of microbe,
tous les types de microbes,
for more than 100 years.
what ultraviolet light is.
la lumière ultraviolette.
that includes infrared,
lumineux, avec les infrarouges
of this group is ultraviolet light.
aux longueurs d'onde courtes.
pour notre sujet aujourd'hui,
by a completely different mechanism
ne détruisent pas les bactéries
of killing a drug-resistant bacteria
résistante aux antibiotiques
is so good at killing all bugs,
to sterilize rooms,
pour stériliser des pièces
ultraviolet light.
des ultraviolets germicides.
in this picture, actually,
pas sur la photo,
is actually a health hazard,
un vrai danger pour la santé,
nos cellules cutanées,
oculaires comme la cataracte.
germicidal, ultraviolet light
des ultraviolets germicides classiques
when there are people around.
stériliser ce qui touche les personnes.
to kill all bacteria,
toutes les bactéries,
dangereux pour l'homme.
background kicked into this story.
de physicien entre en jeu.
wavelength of ultraviolet light
d'onde d'ultraviolets spécifique
n'importe quelle bactérie,
pour les humains.
ce sont les ultraviolets C lointains,
of the ultraviolet spectrum.
d'onde du spectre ultraviolet.
is the surface of our skin,
la surface de notre peau.
some bacteria in the air above the skin.
dans l'espace au-dessus de la peau.
ultraviolet light impinges on this.
ultraviolets germicides classiques.
is really good at killing bacteria,
germicide élimine les bactéries,
into the upper layers of our skin,
supérieures de la peau,
those key cells in our skin
des cellules clés de notre peau,
can lead to skin cancer.
le risque de cancer de la peau.
les ultraviolets C lointains –
in the air above them.
à l'air libre au-dessus.
perfectly fine at killing bacteria,
parfaitement les bactéries,
is penetrate into our skin.
solid physics reason for that:
absorbed by all biological materials,
fortement les ultraviolets C lointains,
are really, really, really small,
extrêmement petits,
penetrate them and kill them,
pas de mal à les pénétrer et les éliminer.
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
être capables d'éliminer les bactéries,
et être sans risque.
has been working on
to both these questions
à ces deux questions
surprised to say that,
surpris du résultat,
of physics at work.
aux lois de la physique.
a completely new weapon,
que nous avons à présent une nouvelle arme
contre les superbactéries.
dans les blocs opératoires,
in food preparation areas.
the spread of viruses,
de la diffusion des virus,
lointains dans les écoles,
in airports or airplanes,
dans les aéroports et les avions,
of viruses like H1N1 virus.
de se propager dans le monde.
and well-loved local politician
local connu et apprécié
in the center of Liverpool,
au centre de Liverpool,
in this war against superbugs.
dans la lutte contre les superbactéries.
I've got a question for you.
j'ai une question à vous poser.
in developing this,
vos recherches dans ce domaine
to trying to roll out
à surmonter pour exploiter
that it kills all bacteria,
que cela tue toutes les bactéries.
that before we started,
depuis le départ
of tests about safety,
de tests sur les risques,
than it is about efficacy.
melanoma many years on.
ne se créent pas des années plus tard.
are pretty well done at this point.
presque achevées.
we have to deal with,
de la FDA [Food and Drugs Administration]
in the real world without FDA approval.
cette technique sans l'accord de la FDA.
to launch first in the US,
lancer d'abord aux États-Unis
biologists, doctors,
les biologistes et les médecins
there is a certain skepticism
il y a un certain scepticisme
that UV light is not safe.
les ultraviolets sont dangereux.
ne présente pas de risques »,
we're going to be standing on.
qu'on va s'appuyer.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com