David Brenner: A new weapon in the fight against superbugs
David Brenner: Vũ khí mới trong cuộc chiến chống siêu khuẩn
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
thực sự,
at the moment,
sắp thua trước mắt.
lại siêu khuẩn.
of some soccer fans --
có các fan bóng đá--
celebrating a famous victory
chiến thắng nổi danh
áo thun đỏ,
that's my friend Paul Rice.
tôi và mang nón đỏ
after this picture was taken,
for some minor surgery,
cuộc phẫu thuật nho nhỏ,
a superbug-related infection,
siêu khuẩn,
suốt thời trai trẻ.
from a couple of TEDsters,
từ một vài TEDsters,
personal war on superbugs.
với đám siêu khuẩn.
for a moment.
niên 40 rồi cơ
introduction of antibiotics.
have continued to emerge,
newer and newer drugs
nhiều loại thuốc mới hơn nữa
actually is the origin of superbugs,
là căn nguyên cho ra đời siêu khuẩn,
for which we don't have effective drugs.
có thuốc kháng hiệu quả.
at least some of these superbugs.
ít nhất vài con siêu trùng này.
common ones around today.
thế giới hiện nay.
approach to the problem,
bản dựa trên thuốc,
by the middle of this century
khoảng giữa thế kỉ này
from superbugs will be 10 million.
ra 10 triệu cái chết.
that's actually more
that died of cancer worldwide last year.
trên toàn thế giới vào năm ngoái.
that we're not on a good road,
to this problem is not working.
thuốc thì không khả thi
a physics-based approach --
trên vật lý--
every kind of microbe,
loại vi khuẩn,
for more than 100 years.
100 năm trước rồi.
what ultraviolet light is.
that includes infrared,
bao gồm tia hồng ngoại,
of this group is ultraviolet light.
này là tia cực tím.
by a completely different mechanism
một cơ chế khác hoàn toàn
of killing a drug-resistant bacteria
vi khuẩn kháng thuốc
is so good at killing all bugs,
mọi loại trùng rất tốt,
to sterilize rooms,
nhiều để khử trùng phòng ốc,
phòng phẫu thuật
ultraviolet light.
in this picture, actually,
hình, thực ra,
is actually a health hazard,
như đục thủy tinh thể.
germicidal, ultraviolet light
cực tím nguyên thủy để khử trùng
when there are people around.
con người xung quanh.
to kill all bacteria,
nhiễm trên con người.
background kicked into this story.
gia với tư cách là nhà vật lý học.
wavelength of ultraviolet light
cụ thể của tia cực tím
of the ultraviolet spectrum.
ngắn trong quang phổ cực tím.
is the surface of our skin,
some bacteria in the air above the skin.
tại khoảng không phía trên da.
ultraviolet light impinges on this.
is really good at killing bacteria,
diệt vi khuẩn rất tốt,
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
in the air above them.
perfectly fine at killing bacteria,
vi khuẩn hoàn hảo,
is penetrate into our skin.
solid physics reason for that:
absorbed by all biological materials,
bởi mọi chất liệu sinh học,
are really, really, really small,
cùng, vô cùng, vô cùng bé,
penetrate them and kill them,
xử đẹp hết chúng nó,
is penetrate into skin,
thâm nhập vô da,
the dead-cell area
should be able to kill bacteria,
has been working on
đang nghiên cứu
to both these questions
có đáp án cho cả 2 câu hỏi.
surprised to say that,
nhiên để nói thế,
of physics at work.
vật lý mà thôi.
a completely new weapon,
vũ khí hoàn toàn mới
in food preparation areas.
the spread of viruses,
in airports or airplanes,
of viruses like H1N1 virus.
and well-loved local politician
được yêu mến tại địa phương
ông ấy tại Liverpool,
in the center of Liverpool,
tưởng niệm giữa trung tâm thành phố,
in this war against superbugs.
bước đột phá lớn trong cuộc chiến này,
I've got a question for you.
dành cho ông.
in developing this,
lực của ông
to trying to roll out
đọng khi đưa ra
that it kills all bacteria,
biết nó có thể diệt mọi vi khuẩn,
that before we started,
chắc chắn rồi.
of tests about safety,
nghiệm an toàn nữa.
than it is about efficacy.
melanoma many years on.
triển u ác tính nhiều năm sau đó.
are pretty well done at this point.
mãn yêu cầu trên.
we have to deal with,
(US Food and Drugs Administration)
in the real world without FDA approval.
to launch first in the US,
biologists, doctors,
there is a certain skepticism
that UV light is not safe.
we're going to be standing on.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com