David Brenner: A new weapon in the fight against superbugs
David Brenner: Uma nova arma na luta contra as superbactérias
We are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that. Full bio
Double-click the English transcript below to play the video.
at the moment,
já que vou falar sobre as superbactérias,
of some soccer fans --
de torcedores de futebol?
celebrating a famous victory
celebrando uma famosa vitória
that's my friend Paul Rice.
está o meu amigo Paul Rice.
after this picture was taken,
for some minor surgery,
uma pequena cirurgia,
a superbug-related infection,
relacionada às superbactérias
from a couple of TEDsters,
de alguns TEDsters,
personal war on superbugs.
for a moment.
por um momento.
introduction of antibiotics.
have continued to emerge,
continuaram a surgir,
newer and newer drugs
cada vez mais novos
actually is the origin of superbugs,
origem às superbactérias,
for which we don't have effective drugs.
para as quais não há remédios efetivos.
at least some of these superbugs.
reconhecerão algumas dessas.
common ones around today.
cerca de 700 mil pessoas
às superbactérias.
approach to the problem,
através do uso de medicamentos,
by the middle of this century
é que até o meio do século
from superbugs will be 10 million.
chegará a 10 milhões de mortes.
that's actually more
that died of cancer worldwide last year.
de câncer ano passado no mundo todo.
that we're not on a good road,
estamos num caminho bom,
to this problem is not working.
não está funcionando.
a physics-based approach --
ter uma abordagem baseada na física...
every kind of microbe,
for more than 100 years.
what ultraviolet light is.
o que é uma luz ultravioleta.
that includes infrared,
o infravermelho, a luz visível,
of this group is ultraviolet light.
que tem comprimento de onda curto.
by a completely different mechanism
com um mecanismo totalmente distinto
of killing a drug-resistant bacteria
uma bactéria resistente a remédios
is so good at killing all bugs,
em matar todas as bactérias,
to sterilize rooms,
para esterilizar salas,
ultraviolet light.
com luz ultravioleta germicida.
in this picture, actually,
is actually a health hazard,
danificar células em nossos olhos,
germicidal, ultraviolet light
ultravioleta germicida convencional
principalmente quando há gente por perto.
when there are people around.
to kill all bacteria,
para exposição humana.
background kicked into this story.
em física entra na história.
wavelength of ultraviolet light
um comprimento de onda específico
e pode ser segura para a exposição humana.
é chamado de "far-UVC",
of the ultraviolet spectrum.
de onda do espectro ultravioleta.
is the surface of our skin,
some bacteria in the air above the skin.
bactérias no ar, acima dela.
ultraviolet light impinges on this.
germicida convencional atua aqui.
is really good at killing bacteria,
é ótima em matar bactérias,
as camadas superiores da nossa pele
into the upper layers of our skin,
those key cells in our skin
can lead to skin cancer.
podem levar a um câncer de pele.
bactérias no ar acima dela.
in the air above them.
perfectly fine at killing bacteria,
perfeitamente as bactérias,
is penetrate into our skin.
penetra na nossa pele.
solid physics reason for that:
explicação física para isso:
absorbed by all biological materials,
por todos os materiais biológicos,
are really, really, really small,
extremamente pequenos,
penetrate them and kill them,
penetrá-las e matá-las,
is penetrate into skin,
the dead-cell area
should be able to kill bacteria,
conseguir matar bactérias,
has been working on
nos últimos cinco ou seis anos,
ambas as perguntas é um enfático "sim".
to both these questions
mas não fico muito surpreso,
surprised to say that,
a lei da física funcionando.
of physics at work.
a completely new weapon,
uma arma completamente nova,
far-UVC em centros cirúrgicos.
in food preparation areas.
de preparação de comida.
the spread of viruses,
da propagação de vírus,
da gripe e do sarampo;
in airports or airplanes,
em aviões e aeroportos,
of viruses like H1N1 virus.
global de vírus como o H1N1.
and well-loved local politician
amado e conhecido
in the center of Liverpool,
em sua memória no centro de Liverpool,
in this war against superbugs.
avanço na guerra contra superbactérias.
isso está ao nosso alcance.
I've got a question for you.
David, tenho uma pergunta.
in developing this,
do desenvolvimento você está
to trying to roll out
que restam para derrubar
that it kills all bacteria,
que ela mata todas as bactérias,
that before we started,
mas já a testamos bastante.
of tests about safety,
e mais testes de segurança,
than it is about efficacy.
de segurança do que de eficácia.
e também testes a longo prazo,
melanoma many years on.
surgimento de melanomas no futuro.
are pretty well done at this point.
praticamente terminaram.
we have to deal with,
in the real world without FDA approval.
no mundo real sem a aprovação da FDA.
to launch first in the US,
primeiro ou em outro lugar?
biologists, doctors,
biologistas, médicos,
there is a certain skepticism
existe um ceticismo,
that UV light is not safe.
que a luz UV não é segura.
mas os dados estão lá,
we're going to be standing on.
pode ser um trabalho muito importante.
for sharing this with us.
ABOUT THE SPEAKER
David Brenner - Radiation scientistWe are decidedly losing the war against superbugs, and with a projected annual death toll by 2050 of 10 million people. David Brenner would like to stop that.
Why you should listen
David Brenner directs the Center for Radiological Research at Columbia University Medical Center in New York City and has numerous distinctions within his field such as the Oxford University Weldon Prize and the Radiation Research Society Failla Gold Medal Award. Founded by a student of Marie Curie more than a century ago, the Center for Radiological Research is committed to exploiting all forms of radiation to improve medical care.
As Brenner sees it, radiation is very much a two-edged sword -- used in the right way it has revolutionized modern medicine, such as through CT scans and as a cure for many cancers. But radiation used in the wrong way can be harmful. To maximize the benefits of the many different types of radiation, we need to understand exactly how they affect us, from our DNA to the whole person.
Over the past six years, Brenner and his team have applied this idea in working towards a safe way to kill drug-resistant bacteria such as MRSA, as well as airborne microbes such as influenza and TB, using a unique type of ultra-violet light, known as far-UVC.
In short, it is pure physics -- far-UVC light is safe for us because it cannot even penetrate through the dead-cell layer on the surface of our skin or the tear layer on the surface of our eyes. But because bacteria and viruses are physically very small, far-UVC light does have enough penetration to efficiently kill them.
Brenner envisions a wide range of applications for this new weapon in the war against superbugs, such as in operating rooms during surgery to minimize the risk of surgical site infections, in schools to prevent the spread of influenza or measles, in shelters to prevent the spread of TB, or in airplanes and airports to prevent the global spread of viruses like H1N1.
David Brenner | Speaker | TED.com