Paula Hammond: A new superweapon in the fight against cancer
Паула Хамонд: Ново супероружје во борбата против ракот.
Paula Hammond, head of MIT's Department of Chemical Engineering, is developing new technologies to kill cancer cells. Full bio
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back over and over again,
одново и одново,
and drug-resistant ones,
оние отпорни на лекови,
третман
лекови.
forms of cancer.
рак.
how to address relatively well
научено како да ги третираме
drugs and surgery.
и хирушки зафати.
very aggressive forms of cancer
се како
опстанат.
from a genetic mutation.
мутација.
мутирале на таков начин
inside these tumor cells
and unimagined modes of survival,
незамисливи начини на преживување,
преживее
третмани.
in which a gene allows a cell,
овозможува на клетката
spits out the drug.
лекот.
of the many genetic tricks
трикови,
негативец, ракот.
with incredible superpowers.
супермоќи.
mode of attack.
known as siRNA.
siRNA.
го блокира.
can turn off a specific gene
одреден ген
these gene blockers in medicine.
медицината.
or our tissues,
through its journey through the body
патува низ телото,
inside the cancer cell.
во канцерогената клетка.
with siRNA, the gene blocker,
со siRNA, блокаторот на гени,
преживување,
со хемотерапијата.
to get through the bloodstream,
крвотокот,
to penetrate the tumor tissue,
на туморот,
to be taken up inside the cancer cell.
канцерогената клетка.
the size of a human hair.
од човечко влакно.
at how we can build this nanoparticle.
можеме да изградиме ваква наночестичка.
with the nanoparticle core.
the chemotherapy drug.
хемотерапевтски лек.
actually end the tumor cell's life.
на туморозната клетка.
negatively charged,
наелектризирана,
of positively charged polymer.
наелектризиран полимер.
molecules stick together
се привлекуваат
with a protective layer
from degrading in the bloodstream.
во крвотокот.
we have to think about.
треба да мислиме.
obstacle of all.
сите.
needs to be targeted,
to the supervillain cells
суперзлосторничките клетки
immune-defense system:
имуно-одбрамбен систем.
таму,
елиминираат.
is considered a foreign object.
препознаваат како туѓо тело.
past the tumor defense system.
забележи одбрамбениот систем на туморот.
of getting rid of the foreign object
negatively charged layer
наелектризиран слој
of the naturally charged,
природно наелектризираните,
that resides in our body.
наоѓаат во нашите тела.
around the nanoparticle
наночестичката,
cloaking effect.
the nanoparticle
наночестичката
до туморот,
за туморозните клетки.
takes up the nanoparticle,
зема наночестичката,
inside the cancer cell
канцерогената клетка
Одиме!
and block those survival genes.
блокира гените одговорни за преживување.
those genetic superpowers.
супермоќи
with no special defenses.
некоја особена одбрана.
comes out of the core
излегува од јадрото
cleanly and efficiently.
чисто и ефикасно.
different kinds of mutations,
различни видови на мутации,
particles in animals
честици врз животни,
of triple-negative breast cancer.
на тројно-негативен рак на дојка.
го содржи токму оној ген
exhibits the gene
as soon as it is delivered.
лекот против ракот.
it "dox" -- is the cancer drug
"докс" -- е лекот
for breast cancer.
ракот на дојка.
with a dox core, dox only.
јадро на докс, единствено докс.
over a period of two weeks.
период од две недели.
our combination superweapon.
супероружје.
against the chemo pump,
хемотерапевтската пумпа,
did the tumors stop growing,
туморите престанаа да растат
елиминирани.
is that it can be personalized.
може да се персонализира.
на siRNA
одбрамбените механизми на туморот.
and tumor defense mechanisms.
into the nanoparticle core.
јадрото на наночестичката.
тестираат пациентите
tumor genetic types,
тумори,
can benefit from this strategy
пациенти би имале корист од овој
можеме да ги користиме.
a special chord with me.
at very late stages,
доцна фаза,
of genetic mutations.
многу генетски мутации.
for 75 percent of patients.
in a drug-resistant form.
на лекови.
supervillains out there.
постојат.
нашето супероружје
работам со моите пациенти.
Mimi, and her daughter, Paige.
Мими и ќерка ѝ Пејџ.
by the optimism and strength
силата
ја демонстрираа
поддршка.
about the different technologies
технологии
about these efforts
кои ги правиме
really elegant science.
наука.
the power of engineering
инженерингот
move forward in their careers,
во своите кариери,
health problems in the world --
здравствени проблеми --
disorders, infectious disease --
невролошките пореметувања, заразните
инжинеринг мене ми ја отвори вратата
found a way to open doors for me,
that of molecules,
ABOUT THE SPEAKER
Paula Hammond - Medical researcher and educatorPaula Hammond, head of MIT's Department of Chemical Engineering, is developing new technologies to kill cancer cells.
Why you should listen
Professor Paula T. Hammond is the Head of the Department of Chemical Engineering and David H. Koch Chair Professor in Engineering at the Massachusetts Institute of Technology (MIT). She is a member of MIT's Koch Institute for Integrative Cancer Research, the MIT Energy Initiative and a founding member of the MIT Institute for Soldier Nanotechnology. She has recently been named the new head of the Department of Chemical Engineering (ChemE). She is the first woman and the first person of color appointed to the post. She also served as the Executive Officer (Associate Chair) of the Chemical Engineering Department (2008-2011).
Professor Hammond was elected into the 2013 Class of the American Academy of Arts and Sciences. She is also the recipient of the 2013 AIChE Charles M. A. Stine Award, which is bestowed annually to a leading researcher in recognition of outstanding contributions to the field of materials science and engineering, and the 2014 Alpha Chi Sigma Award for Chemical Engineering Research. She was also selected to receive the Department of Defense Ovarian Cancer Teal Innovator Award in 2013. She has been listed in the prestigious Highly Cited Researchers 2014 list, published by Thomson Reuters in the Materials Science category. This list contains the world's most influential researchers across 21 scientific disciplines based on highly cited papers in the 2002-2012 period. She is also included in the report: The World's Most Influential Scientific Minds 2014.
Professor Hammond serves as an Associate Editor of the American Chemical Society journal, ACS Nano. She has published over 250 scientific papers and holds over 20 patents based on her research at MIT. She was named a Fellow of the American Physical Society, the American Institute of Biological and Medical Engineers, and the American Chemical Society Polymer Division. In 2010, she was named the Scientist of the Year by the Harvard Foundation.
Professor Hammond received her B.S. in Chemical Engineering from MIT in 1984, and her M.S. from Georgia Tech in 1988 and earned her Ph.D. in 1993 from MIT.
Paula Hammond | Speaker | TED.com