ABOUT THE SPEAKER
Harvey Fineberg - Health policy expert
Harvey Fineberg studies medical decisionmaking -- from how we roll out new medical technology, to how we cope with new illnesses and threatened epidemics.

Why you should listen

As president of the Institute of Medicine, Harvey Fineberg thinks deeply about new medicine, both its broad possibilities and the moral and philosophical questions that each new treatment brings. How do we decide which treatment to use in a tricky case -- both individually and as a community? Is it fair that the richest hospitals get the best healthcare? Who should bear the risk (and gain the reward) of trying the newest treatments?

Fineberg helped found and served as president of the Society for Medical Decision Making and also served as consultant to the World Health Organization. He was provost of Harvard from 1997 to 2001, following thirteen years as Dean of the Harvard School of Public Health. He has devoted most of his academic career to the fields of health policy and medical decision making. His past research has focused on the process of policy development and implementation, assessment of medical technology, evaluation and use of vaccines, and dissemination of medical innovations.

More profile about the speaker
Harvey Fineberg | Speaker | TED.com
TED2011

Harvey Fineberg: Are we ready for neo-evolution?

哈维•芬堡: 我們準備好迎接新進化論嗎?

Filmed:
1,108,576 views

醫學倫理學家哈维•芬堡告訴我們人類演進的三條道路: 完全停止演進、自然的演進 -- 或是藉由基因改造來演進,使我們變的更聰明、更迅速,變的更好。 新進化論就在我們十指之間。 我們要如何應用它呢?
- Health policy expert
Harvey Fineberg studies medical decisionmaking -- from how we roll out new medical technology, to how we cope with new illnesses and threatened epidemics. Full bio

Double-click the English transcript below to play the video.

00:15
How would you like to be better than you are?
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你想要自己比現在的你更好嗎?
00:19
Suppose假設 I said
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如果我說,
00:21
that, with just a few少數 changes變化 in your genes基因,
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只需要在你的基因中做幾個改變,
00:23
you could get a better memory記憶 --
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你就可以擁有更好的記憶力 --
00:25
more precise精確,
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更精準、
00:27
more accurate準確 and quicker更快.
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更精確、更迅速。
00:30
Or maybe you'd like to be more fit適合, stronger,
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或者你想要更苗條、更強壯、
00:33
with more stamina耐力.
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更有耐力。
00:35
Would you like to be more attractive有吸引力 and self-confident自信?
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你想變的更具吸引力、更有自信嗎?
00:39
How about living活的 longer with good health健康?
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活的更久、更健康呢?
00:42
Or perhaps也許 you're one of those
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又或者你是屬於那些
00:44
who's誰是 always yearned嚮往 for more creativity創造力.
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一直嚮往自己能更有創造力的人。
00:47
Which哪一個 one would you like the most?
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你最想要哪一種呢?
00:51
Which哪一個 would you like, if you could have just one?
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如果你只能選一種,你會想要哪一種?
00:53
(Audience聽眾 Member會員: Creativity創造力.)
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(聽眾: 創造力。)
00:55
Creativity創造力.
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創造力。
00:57
How many許多 people would choose選擇 creativity創造力?
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多少人會選擇創造力呢?
00:59
Raise提高 your hands. Let me see.
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舉起你的手讓我看看。
01:01
A few少數. Probably大概 about as many許多 as there are creative創作的 people here.
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有一些人。 大概就跟在坐有創造力的人一樣多吧。
01:04
(Laughter笑聲) That's very good.
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很好。
01:06
How many許多 would opt選擇 for memory記憶?
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有多少人會選擇記憶力呢?
01:09
Quite相當 a few少數 more.
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比剛才多了一些人。
01:11
How about fitness身體素質?
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那健康呢?
01:13
A few少數 less.
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人少了一些。
01:15
What about longevity長壽?
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那更長壽呢?
01:17
Ah, the majority多數. That makes品牌 me feel very good as a doctor醫生.
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喔,大多數的人。 這讓身為醫師的我覺得很好。
01:21
If you could have any one of these,
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如果你能擁有任何一種,
01:24
it would be a very different不同 world世界.
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這個世界都會非常不一樣。
01:26
Is it just imaginary假想?
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這只是幻想嗎?
01:28
Or, is it, perhaps也許, possible可能?
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還是,這確實有可能呢?
01:31
Evolution演化 has been a perennial多年生 topic話題
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進化論在TED研討會上
01:34
here at the TEDTED Conference會議,
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一直是個常被討論的主題,
01:37
but I want to give you today今天
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但是我今天是要以一個醫師的觀點
01:39
one doctor's醫生 take on the subject學科.
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來討論這個主題。
01:41
The great 20th-centuryTH-世紀 geneticist遺傳學家,
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20世紀一名偉大的遺傳學家
01:43
T.G. Dobzhansky杜布贊斯基,
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费奥多西·多布然斯基,
01:45
who was also a communicant聖餐
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他同時是俄國東正教
01:47
in the Russian俄語 Orthodox正統 Church教會,
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的一名傳信者,
01:49
once一旦 wrote an essay文章 that he titled標題
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他曾寫了一篇文章,
01:52
"Nothing in Biology生物學 Makes使 Sense
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標題是〈生物學中沒有什麼是有道理的 --
01:55
Except in the Light of Evolution演化."
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除了按照進化論的那些〉。
01:58
Now if you are one of those
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現在,如果你是那些
02:00
who does not accept接受 the evidence證據 for biological生物 evolution演化,
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不接受生物進化論的證據的人,
02:03
this would be a very good time to turn off your hearing聽力 aid援助,
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現在是關掉你的助聽器的好時機,
02:06
take out your personal個人 communications通訊 device設備 --
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拿出你的個人通訊設備 --
02:08
I give you permission允許 --
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我准許你們這樣做 --
02:10
and perhaps也許 take another另一個 look at Kathryn凱瑟琳 Schultz's舒爾茨 book on being存在 wrong錯誤,
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或許你該再看一下凱瑟琳• 舒爾茨寫有關犯錯的那本書,
02:13
because nothing in the rest休息 of this talk
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因為接下來要講的東西
02:15
is going to make any sense whatsoever任何 to you.
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對你來說都是沒有任何意義的。
02:18
(Laughter笑聲)
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(笑聲)
02:20
But if you do accept接受
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但是如果你是
02:22
biological生物 evolution演化,
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接受生物進化論的,
02:25
consider考慮 this:
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仔細想想:
02:27
is it just about the past過去,
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它只跟過去有關嗎,
02:29
or is it about the future未來?
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還是它也跟未來有關?
02:31
Does it apply應用 to others其他,
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它是適用於他人嗎,
02:33
or does it apply應用 to us?
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還是也適用於我們?
02:36
This is another另一個 look at the tree of life.
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這是生命之樹,生物的樹狀圖。
02:39
In this picture圖片,
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在這分支圖當中可以看到,
02:41
I've put a bush襯套 with a center中央 branching分枝 out in all directions方向,
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我把它由一個中心點往各個方向分支出去,
02:44
because if you look at the edges邊緣
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因為如果你看到這個生命之樹
02:46
of the tree of life,
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各個分支的末端,
02:48
every一切 existing現有 species種類
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以進化論的角度來說
02:50
at the tips提示 of those branches分支機構
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每個分支末端的物種
02:52
has succeeded成功 in evolutionary發展的 terms條款:
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都是成功的案例,因為:
02:54
it has survived倖存;
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它生存了下來、
02:56
it has demonstrated證明 a fitness身體素質
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它展現了其適合在它生長環境中
02:58
to its environment環境.
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生存的條件。
03:00
The human人的 part部分 of this branch,
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在這個分支的末端
03:03
way out on one end結束,
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有關人類的部份,
03:06
is, of course課程, the one that we are most interested有興趣 in.
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理所當然是我們最關心的部份。
03:10
We branch off of a common共同 ancestor祖先
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在6至8百萬年前,
03:12
to modern現代 chimpanzees黑猩猩
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我們從一個較低層級的祖先
03:14
about six or eight million百萬 years年份 ago.
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分支出來成了現代的黑猩猩。
03:17
In the interval間隔,
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在這期間,
03:19
there have been perhaps也許 20 or 25
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大概出現過20至25種
03:21
different不同 species種類 of hominids原始人.
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不同形式的人類祖先。
03:24
Some have come and gone走了.
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其中有一些已經不存在。
03:27
We have been here for about 130,000 years年份.
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而我們已經生存了130,000年。
03:31
It may可能 seem似乎 like we're quite相當 remote遠程
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我們或許看似跟生命之樹中
03:33
from other parts部分 of this tree of life,
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其他的分支隔了很遠,
03:36
but actually其實, for the most part部分,
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但實際情形是,大致上來說,
03:39
the basic基本 machinery機械 of our cells細胞
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我們的細胞機構
03:42
is pretty漂亮 much the same相同.
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幾乎是一模一樣的。
03:44
Do you realize實現 that we can take advantage優點
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你知不知道我們可以藉由
03:47
and commandeer徵用 the machinery機械 of a common共同 bacterium細菌
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一種低等細菌體的細胞機構
03:50
to produce生產 the protein蛋白 of human人的 insulin胰島素
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來製造人類胰島素的一種蛋白質
03:53
used to treat對待 diabetics糖尿病?
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來治療糖尿病嗎?
03:55
This is not like human人的 insulin胰島素;
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它不是跟人類的胰島素類似而已,
03:57
this is the same相同 protein蛋白
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它是跟你胰臟分泌出來的
03:59
that is chemically化學 indistinguishable區分
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胰島素裡面的一種蛋白質
04:01
from what comes out of your pancreas胰腺.
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完全一樣。
04:06
And speaking請講 of bacteria,
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講到細菌,
04:08
do you realize實現 that each of us carries攜帶 in our gut腸道
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你知道我們腸子裡的細菌數量
04:11
more bacteria
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比我們身體所有細胞的數量
04:13
than there are cells細胞 in the rest休息 of our body身體?
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還要多嗎?
04:15
Maybe 10 times more.
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大概有10倍之多。
04:17
I mean think of it,
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我說,想想看,
04:19
when Antonio安東尼奧 Damasio達馬西奧 asks about your self-image自我形象,
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當安東尼奧• 達馬斯奧在問你對於自我的形象的時候,
04:22
do you think about the bacteria?
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你有想到這些細菌嗎?
04:26
Our gut腸道 is a wonderfully奇妙 hospitable好客 environment環境
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我們的腸子是一個非常適合
04:28
for those bacteria.
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這些細菌生長的環境。
04:30
It's warm, it's dark黑暗, it's moist,
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它很溫暖、很陰暗、很潮濕,
04:32
it's very cozy舒適.
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非常的舒適。
04:34
And you're going to provide提供 all the nutrition營養 that they could possibly或者 want
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而且那些細菌完全不需要任何工夫,
04:36
with no effort功夫 on their part部分.
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你就會為它們提供任何需要的營養。
04:38
It's really like an Easy簡單 Street for bacteria,
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這簡直是細菌的天堂,
04:41
with the occasional偶然 interruption中斷
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除了偶爾會被
04:44
of the unintended意外 forced被迫 rush to the exit出口.
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強迫性的推向出口。
04:46
But otherwise除此以外,
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除此之外,
04:49
you are a wonderful精彩 environment環境 for those bacteria,
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你就是這些細菌最完美的生長環境,
04:52
just as they are essential必要 to your life.
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而這些細菌對你也一樣重要。
04:55
They help in the digestion消化 of essential必要 nutrients營養成分,
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它們幫助消化分解一些必要的營養素。
04:58
and they protect保護 you against反對 certain某些 diseases疾病.
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它們也保護你不受某些疾病的侵襲。
05:02
But what will come in the future未來?
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但是未來會是怎麼樣呢?
05:04
Are we at some kind of evolutionary發展的 equipoise平衡力
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身為一個物種,我們的演進
05:07
as a species種類?
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已經達到一種平衡了嗎?
05:09
Or, are we destined注定
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又或者,我們就是註定
05:11
to become成為 something different不同 --
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要變得不一樣 --
05:13
something, perhaps也許, even better adapted適應
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要變得更加能夠適應
05:16
to the environment環境?
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外在的環境?
05:18
Now let's take a step back in time
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現在我們回朔到140億年前,
05:21
to the Big Bang, 14 billion十億 years年份 ago --
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宇宙大爆炸 --
05:24
the Earth地球, the solar太陽能 system系統,
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45億年前,
05:26
about four and a half billion十億 years年份 --
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地球與太陽系的形成 --
05:29
the first signs跡象 of proto-life原生活,
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30~40億年前,
05:31
maybe three to four billion十億 years年份 ago on Earth地球 --
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第一次出現原始生命的跡象 --
05:33
the first multi-celled多細胞 organisms生物,
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大概8~10億年前,
05:36
perhaps也許 as much
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第一個多細胞生物
05:38
as 800 or a billion十億 years年份 ago --
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誕生了 --
05:41
and then the human人的 species種類,
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最後,在這130,000年來
05:43
finally最後 emerging新興
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人類這個物種
05:45
in the last 130,000 years年份.
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終於出現了。
05:48
In this vast廣大 unfinished未完成 symphony交響樂 of the universe宇宙,
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宇宙就像首未完成的交響樂,
05:51
life on Earth地球 is like a brief簡要 measure測量;
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地球上的生命就像其中幾個小節;
05:54
the animal動物 kingdom王國,
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動物王國,
05:56
like a single measure測量;
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就像其中一個小節;
05:59
and human人的 life,
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而人類,
06:01
a small grace恩典 note注意.
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就像其中一個音符而已。
06:03
That was us.
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這就是我們。
06:06
That also constitutes構成 the entertainment娛樂 portion一部分 of this talk,
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這也是這個研討會中較有娛樂性的部分,
06:08
so I hope希望 you enjoyed享受 it.
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希望你們有感受到。
06:10
(Laughter笑聲)
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(笑聲)
06:12
Now when I was a freshman新生 in college學院,
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我在大學一年級的時候
06:15
I took my first biology生物學 class.
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上了我人生中第一堂生物課。
06:17
I was fascinated入迷
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生物學的高雅及美麗
06:19
by the elegance優雅 and beauty美女 of biology生物學.
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深深的吸引了我。
06:22
I became成為 enamored迷戀 of the power功率 of evolution演化,
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我變得非常地著迷於進化的力量,
06:25
and I realized實現 something very fundamental基本的:
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並且我了解到了一些很基本的事情:
06:27
in most of the existence存在 of life
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在大部分現行存在的單細胞有機體
06:29
in single-celled單細胞 organisms生物,
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的生命當中,
06:31
each cell細胞 simply只是 divides分歧,
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每個細胞就這樣簡單的分裂,
06:33
and all of the genetic遺傳 energy能源 of that cell細胞
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然後該細胞中所有的基因能量
06:36
is carried攜帶的 on in both daughter女兒 cells細胞.
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就被帶到了它的子細胞。
06:39
But at the time multi-celled多細胞 organisms生物 come online線上,
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但是到了多細胞有機體的出現之後
06:43
things start開始 to change更改.
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就變的不一樣了。
06:45
Sexual有性 reproduction再生產 enters進入 the picture圖片.
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有性生殖開始出現。
06:48
And very importantly重要的,
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而且非常重要的是,
06:50
with the introduction介紹 of sexual有性 reproduction再生產
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透過可以將基因傳遞給後代的
06:53
that passes通行證 on the genome基因組,
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有性生殖,
06:55
the rest休息 of the body身體
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身體的其他部位
06:57
becomes expendable消耗.
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變得可以被消耗的。
06:59
In fact事實, you could say
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事實上,你可以說
07:02
that the inevitability必然性 of the death死亡 of our bodies身體
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在進化的時間線上,
07:05
enters進入 in evolutionary發展的 time
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我們身體最終會凋零死亡的必然性
07:07
at the same相同 moment時刻
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跟有性生殖的開始
07:09
as sexual有性 reproduction再生產.
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是同時出現的。
07:11
Now I have to confess承認,
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現在我必須說,
07:13
when I was a college學院 undergraduate大學本科,
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當我還是大學生的時候,
07:15
I thought, okay, sex性別/death死亡, sex性別/death死亡, death死亡 for sex性別 --
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我想,好吧,性/死亡,性/死亡,為了性而死亡--
07:19
it seemed似乎 pretty漂亮 reasonable合理 at the time,
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在當時似乎是非常有道理的,
07:22
but with each passing通過 year,
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但一年一年過去,
07:24
I've come to have increasing增加 doubts疑惑.
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我開始有愈來愈多的懷疑。
07:26
I've come to understand理解 the sentiments情緒 of George喬治 Burns伯恩斯,
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我開始理解喬治• 伯恩斯的思想,
07:29
who was performing執行 still in Las拉斯維加斯 Vegas拉斯維加斯
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他當時還在拉斯維加斯表演,
07:31
well into his 90s.
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直到他90多歲。
07:33
And one night, there's a knock at his hotel旅館 room房間 door.
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一天晚上,有人敲他下榻旅館的門。
07:35
He answers答案 the door.
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他應了門。
07:37
Standing常設 before him is a gorgeous華麗, scantily衣著暴露 clad包層的 showgirl歌女.
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站在門口的是個非常美麗又穿的很少的舞女。
07:40
She looks容貌 at him and says,
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他看著他說:
07:42
"I'm here for super sex性別."
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「我是來跟你消魂的做愛的。 」
07:45
"That's fine," says George喬治, "I'll take the soup."
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「好吧」,喬治說,「我就喝湯吧」" ("super sex超級性交" 發音似 "soup or sex湯或是性交")
07:48
(Laughter笑聲)
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(笑聲)
07:52
I came來了 to realize實現,
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我開始意識到
07:54
as a physician醫師,
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作為一個醫師,
07:56
that I was working加工 toward a goal目標
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一直以來我努力的目標與
07:59
which哪一個 was different不同 from the goal目標 of evolution演化 --
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進化論的目標是不一樣的--
08:02
not necessarily一定 contradictory矛盾, just different不同.
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不見得互相違背,但就是不同。
08:05
I was trying to preserve保留 the body身體.
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我一直嘗試去保存身體。
08:07
I wanted to keep us healthy健康.
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我想要我們保持健康。
08:09
I wanted to restore恢復 health健康 from disease疾病.
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我想要使我們從疾病中恢復健康。
08:12
I wanted us to live生活 long and healthy健康 lives生活.
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我想要我們活的又長久又健康。
08:15
Evolution演化 is all about passing通過 on the genome基因組
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而進化全是為了把基因
08:18
to the next下一個 generation,
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傳遞給下一代,
08:20
adapting適應 and surviving倖存
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一代接著一代
08:23
through通過 generation after generation.
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適應並存活下去。
08:25
From an evolutionary發展的 point of view視圖,
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從進化的觀點來看,
08:28
you and I are like the booster加速器 rockets火箭
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我們就像是帶有推進器的火箭,
08:30
designed設計 to send發送 the genetic遺傳 payload有效載荷
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被設計來把"基因"載送到
08:32
into the next下一個 level水平 of orbit軌道
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下一層的軌道
08:34
and then drop下降 off into the sea.
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然後落下掉進海裡。
08:37
I think we would all understand理解 the sentiment情緒 that Woody伍迪 Allen艾倫 expressed表達
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我想我們都應該可以了解伍迪•艾倫所說的,
08:40
when he said, "I don't want to achieve實現 immortality不朽 through通過 my work.
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他說:「 我不想透過我的成就而不朽。」
08:44
I want to achieve實現 it through通過 not dying垂死."
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「 我想透過不死而不朽。」
08:46
(Laughter笑聲)
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(笑聲)
08:49
Evolution演化 does not necessarily一定
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進化,不一定
08:52
favor偏愛 the longest-lived壽命最長.
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是偏向活得最久的。
08:54
It doesn't necessarily一定 favor偏愛 the biggest最大
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他不一定偏向最大的、
08:56
or the strongest最強 or the fastest最快的,
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最強壯的或是最快速的,
08:58
and not even the smartest最聰明的.
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甚至也不偏向最聰明的。
09:00
Evolution演化 favors好處
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進化,偏向
09:02
those creatures生物 best最好 adapted適應
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那些最能夠適應
09:05
to their environment環境.
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其環境的生物。
09:07
That is the sole唯一 test測試
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它完全是考驗著
09:09
of survival生存 and success成功.
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成功存活下去的能力。
09:11
At the bottom底部 of the ocean海洋,
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在海底,
09:13
bacteria that are thermophilic嗜熱
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耐高溫的細菌
09:15
and can survive生存 at the steam蒸汽 vent發洩 heat
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可以存活在熱蒸汽的環境;
09:18
that would otherwise除此以外 produce生產, if fish were there,
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如果魚在那種環境,
09:21
sous-vide真空低溫烹調法 cooked fish,
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就會慢慢的被煮熟 (sous-vide法式真空低溫(約60度C)煮法);
09:23
nevertheless雖然, have managed管理
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然而,它們卻可以
09:25
to make that a hospitable好客 environment環境 for them.
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適應並接受那樣的環境。
09:30
So what does this mean,
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這說明了什麼呢?
09:33
as we look back at what has happened發生 in evolution演化,
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當我們回頭看看進化的過程發生了什麼事情,
09:36
and as we think about the place地點 again
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當我們再次想想人類在進化中
09:39
of humans人類 in evolution演化,
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扮演的角色,
09:42
and particularly尤其 as we look ahead
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尤其是向前看到
09:45
to the next下一個 phase,
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下一個階段,
09:47
I would say
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我會跟你說
09:49
that there are a number of possibilities可能性.
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有許多的可能性。
09:52
The first is that we will not evolve發展.
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第一種是我們停止進化。
09:57
We have reached到達
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我們已經達到
09:59
a kind of equipoise平衡力.
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一種平衡。
10:01
And the reasoning推理 behind背後 that would be,
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這背後的原因是,
10:03
first, we have, through通過 medicine醫學,
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首先,我們透過醫學
10:06
managed管理 to preserve保留 a lot of genes基因
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保存下來很多本來
10:08
that would otherwise除此以外 be selected out
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會被淘汰、從人口中消失
10:10
and be removed去除 from the population人口.
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的那些基因。
10:12
And secondly其次, we as a species種類
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再者,我們是一個能夠
10:14
have so configured配置 our environment環境
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配置環境的物種,
10:17
that we have managed管理 to make it adapt適應 to us
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就跟我們適應環境一樣,
10:20
as well as we adapt適應 to it.
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我們讓環境來適應我們。
10:23
And by the way, we immigrate移民 and circulate流通
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另外,我們因為大量的
10:25
and intermix攪和 so much
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移民、流通以及混合,
10:27
that you can't any longer
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我們已經不是相互隔離的,
10:29
have the isolation隔離 that is necessary必要
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而這又正是進化發生
10:31
for evolution演化 to take place地點.
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的必要條件。
10:34
A second第二 possibility可能性
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第二種可能
10:36
is that there will be evolution演化 of the traditional傳統 kind,
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就是傳統的進化方式,
10:39
natural自然, imposed徵收 by the forces軍隊 of nature性質.
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自然的、由自然的力量推進的。
10:44
And the argument論據 here would be
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這個可能性的論點在於
10:46
that the wheels車輪 of evolution演化 grind研磨 slowly慢慢地,
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進化雖然很緩慢,
10:49
but they are inexorable殘酷.
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但是是無法被阻擋或改變的。
10:51
And as far as isolation隔離 goes,
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就隔離性來說,
10:53
when we as a species種類
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身為一個物種,當我們殖民到
10:55
do colonize拓殖 distant遙遠 planets行星,
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其他遙遠的星球時,
10:57
there will be the isolation隔離 and the environmental環境的 changes變化
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就會有環境的變化並有其隔離性,
11:00
that could produce生產 evolution演化
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一種自然進化
11:03
in the natural自然 way.
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必要的隔離性。
11:05
But there's a third第三 possibility可能性,
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但是有第三種可能性,
11:07
an enticing誘人, intriguing奇妙 and frightening可怕的 possibility可能性.
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一種吸引人、引人入勝卻也令人害怕的可能性。
11:10
I call it neo-evolution新發展 --
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我把它稱作新進化論--
11:12
the new evolution演化
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這種新的進化論
11:14
that is not simply只是 natural自然,
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不只是單純自然的發展,
11:16
but guided引導 and chosen選擇
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還會因為我們,做為單一個體,
11:19
by us as individuals個人
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所做的一些決定
11:22
in the choices選擇 that we will make.
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而被引導、發展的。
11:24
Now how could this come about?
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要怎麼讓這個成真呢?
11:27
How could it be possible可能 that we would do this?
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如何能做到這樣呢?
11:30
Consider考慮, first, the reality現實
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第一個考量的是
11:33
that people today今天, in some cultures文化,
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現在,有一其他些文化的人
11:36
are making製造 choices選擇 about their offspring子孫.
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對他們的後代做了一些選擇。
11:39
They're, in some cultures文化,
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在一些文化中,
11:41
choosing選擇 to have more males男性 than females女性.
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他們選擇生男性較多於生女性。
11:44
It's not necessarily一定 good for the society社會,
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這樣對社會不見得是好的,
11:46
but it's what the individual個人 and the family家庭 are choosing選擇.
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但卻是個體與家庭的選擇。
11:50
Think also,
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再想想,
11:52
if it were possible可能 ever
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如果能夠選擇
11:56
for you to choose選擇, not simply只是 to choose選擇 the sex性別 of your child兒童,
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不僅是選擇小孩的性別,
11:59
but for you in your body身體
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還可以選擇在你自己身體中
12:02
to make the genetic遺傳 adjustments調整
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對那些基因進行一些的調整,
12:05
that would cure治愈 or prevent避免 diseases疾病.
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治癒疾病或是預防一些疾病的發生。
12:07
What if you could make the genetic遺傳 changes變化
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如果可以改變基因
12:10
to eliminate消除 diabetes糖尿病 or Alzheimer's老年癡呆症
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來杜絕糖尿病或是阿茲海默症(老人癡呆)
12:13
or reduce減少 the risk風險 of cancer癌症
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或是降低罹患癌症的風險
12:15
or eliminate消除 stroke行程?
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或是杜絕中風的發生呢?
12:17
Wouldn't豈不 you want
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難道你不會想要
12:19
to make those changes變化
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對你的基因
12:21
in your genes基因?
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做那些改變嗎?
12:23
If we look ahead,
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如果我們向前看,
12:25
these kind of changes變化
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這些改變
12:27
are going to be increasingly日益 possible可能.
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是愈來愈有可能達到的。
12:32
The Human人的 Genome基因組 Project項目
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人類基因組計畫
12:34
started開始 in 1990,
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1990年就開始了,
12:36
and it took 13 years年份.
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它花了13年的時間。
12:38
It cost成本 2.7 billion十億 dollars美元.
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花了超過27億美元。
12:43
The year after it was finished in 2004,
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在2004年,該計畫結束一年後
12:46
you could do the same相同 job工作
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你只需要花2000萬美元及3~4個月的時間
12:48
for 20 million百萬 dollars美元 in three to four months個月.
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便可以做出一樣的成果。
12:51
Today今天, you can have a complete完成 sequence序列
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今天,你只需要花費大約20000美元
12:54
of the three billion十億 base基礎 pairs in the human人的 genome基因組
300
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以及大概一個禮拜的時間
12:56
at a cost成本 of about 20,000 dollars美元
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就可以得到完整的基因序列
12:59
and in the space空間 of about a week.
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包含了人體30億個鹼基對的基因序列。
13:01
It won't慣於 be very long
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再過不了多久
13:03
before the reality現實 will be
304
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應該就可以以1000美元
13:05
the 1,000-dollar-美元 human人的 genome基因組,
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得到你的基因序列,
13:07
and it will be increasingly日益 available可得到 for everyone大家.
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並且會愈來愈普及大眾。
13:11
Just a week ago,
307
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就在一個禮拜前,
13:13
the National國民 Academy學院 of Engineering工程
308
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美國工程學院
13:15
awarded頒發 its Draper德雷珀 Prize
309
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頒發了它的查爾斯•斯塔克•德雷珀獎獎
13:17
to Francis弗朗西斯 Arnold阿諾德 and Willem威廉 Stemmer詞幹,
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給弗朗西斯•阿諾以及威廉•史丹摩,
13:19
two scientists科學家們 who independently獨立地 developed發達 techniques技術
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兩位獨立發展出
13:23
to encourage鼓勵 the natural自然 process處理 of evolution演化 to work faster更快
312
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使自然進化更加快速
13:27
and to lead to desirable合意 proteins蛋白質
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並很有效率的
13:29
in a more efficient高效 way --
314
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產生我們所想要的蛋白質--
13:31
what Frances弗朗西絲 Arnold阿諾德 calls電話 "directed針對 evolution演化."
315
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弗朗西斯•阿諾稱之為"引導進化"。
13:35
A couple一對 of years年份 ago, the Lasker拉斯克 Prize
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幾年前拉斯克奖
13:38
was awarded頒發 to the scientist科學家 Shinya Yamanaka山中
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被頒發給科學家山中伸彌的研究,
13:41
for his research研究
318
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在其研究中
13:43
in which哪一個 he took an adult成人 skin皮膚 cell細胞,
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它取出了一個成人的細胞,
13:45
a fibroblast成纖維細胞,
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一個神經膠原母細胞,
13:47
and by manipulating操縱 just four genes基因,
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透過只改變了四個基因
13:50
he induced誘發 that cell細胞
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他使這個細胞
13:52
to revert還原 to a pluripotential多潛能 stem cell細胞 --
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還原到原始多能幹細胞--
13:56
a cell細胞 potentially可能 capable
324
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一個可以長成
13:59
of becoming變得 any cell細胞 in your body身體.
325
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你身體中任何一種細胞的細胞。
14:02
These changes變化 are coming未來.
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這些改變就要來臨。
14:04
The same相同 technology技術
327
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使用讓細菌製造胰島素
14:06
that has produced生成 the human人的 insulin胰島素 in bacteria
328
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一樣的技術就能
14:08
can make viruses病毒
329
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製造出病毒,
14:10
that will not only protect保護 you against反對 themselves他們自己,
330
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一種不只讓你能夠抵抗它們,
14:13
but induce促使 immunity免疫 against反對 other viruses病毒.
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甚至讓你對其他的病毒也免疫的病毒。
14:15
Believe it or not,
332
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你是否相信,
14:17
there's an experimental試驗 trial審訊 going on
333
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有個實驗正在研究
14:19
with vaccine疫苗 against反對 influenza流感
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由菸草植物細胞培育出來的
14:22
that has been grown長大的 in the cells細胞 of a tobacco煙草 plant.
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一種流行性感冒的疫苗。
14:26
Can you imagine想像 something good coming未來 out of tobacco煙草?
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你可以想像菸草也能提供有益的東西嗎?
14:30
These are all reality現實 today今天,
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這些都是現今可以實現的,
14:33
and [in] the future未來, will be evermore possible可能.
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而在未來,有更多的可能性會被實現。
14:36
Imagine想像 then
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想像一下到時候
14:38
just two other little changes變化.
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能夠改變的兩個小東西。
14:41
You can change更改 the cells細胞 in your body身體,
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你可以改變你身體裡的細胞,
14:43
but what if you could change更改 the cells細胞 in your offspring子孫?
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但如果你可以改變你下一代的細胞呢?
14:47
What if you could change更改 the sperm精子 and the ovaOVA,
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如果你可以對精子和卵子進行改變,
14:49
or change更改 the newly fertilized受精 egg,
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或是對剛受精的受精卵進行改變,
14:52
and give your offspring子孫 a better chance機會
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讓你的下一代
14:54
at a healthier健康 life --
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有更健康的生命--
14:56
eliminate消除 the diabetes糖尿病, eliminate消除 the hemophilia血友病,
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杜絕糖尿病、血友病,
14:58
reduce減少 the risk風險 of cancer癌症?
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降低罹患癌症的機率呢?
15:00
Who doesn't want healthier健康 children孩子?
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有誰不想要更健康的小孩呢?
15:03
And then, that same相同 analytic解析 technology技術,
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到時候,這些能做出改變、
15:06
that same相同 engine發動機 of science科學
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預防疾病的科學分析技術
15:08
that can produce生產
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同樣的科學技術
15:10
the changes變化 to prevent避免 disease疾病,
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能讓我們
15:12
will also enable啟用 us
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調整並取得一些
15:15
to adopt採用 super-attributes超級屬性,
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超級屬性,
15:17
hyper-capacities超能力 --
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超高的容量--
15:19
that better memory記憶.
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更好的記憶力。
15:21
Why not have the quick wit風趣
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何不快速擁有像
15:23
of a Ken Jennings詹寧斯,
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肯•詹寧斯(美國〈危險邊緣〉機智問答節目冠軍) 的機智,
15:25
especially特別 if you can augment增加 it
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特別是如果你能夠把它再加上
15:27
with the next下一個 generation of the Watson沃森 machine?
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下一代沃森機器的能力呢? (沃森機器為IBM推出的人工智慧電腦,在〈危險邊緣〉中挑戰肯•詹寧斯)
15:30
Why not have the quick twitch抽搐 muscle肌肉
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何不擁有快速收縮的肌肉,
15:33
that will enable啟用 you to run faster更快 and longer?
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讓你可以跑的更快、更遠?
15:36
Why not live生活 longer?
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何不活的更久?
15:40
These will be irresistible不可抗拒.
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這些變化都讓人無法拒絕。
15:42
And when we are at a position位置
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當我們在一個可以傳給下一代、
15:45
where we can pass通過 it on to the next下一個 generation,
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選擇我們想要取得的屬性
15:47
and we can adopt採用 the attributes屬性 we want,
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的位置上時,
15:50
we will have converted轉換
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我們就把
15:53
old-style老式 evolution演化
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傳統的進化論推進到
15:55
into neo-evolution新發展.
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新的進化論。
15:57
We'll take a process處理
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我們將可以把一般
15:59
that normally一般 might威力 require要求 100,000 years年份,
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需要100,000年的進化過程
16:01
and we can compress壓縮 it down to a thousand years年份 --
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壓縮到1000年--
16:04
and maybe even in the next下一個 100 years年份.
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甚至在接下來的100年就達成。
16:07
These are choices選擇
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這些將是在你的孫子
16:09
that your grandchildren孫子,
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或是他們的孫子
16:11
or their grandchildren孫子,
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那個年代
16:13
are going to have before them.
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就可以擁有的選擇。
16:16
Will we use these choices選擇
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我們會把這些選擇用來
16:19
to make a society社會 that is better,
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讓這個社會更好、
16:22
that is more successful成功, that is kinder金德?
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更成功、更和藹嗎?
16:25
Or, will we selectively選擇 choose選擇 different不同 attributes屬性
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還是我們會選擇性的
16:28
that we want for some of us
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選擇那些我們自己想擁有
16:30
and not for others其他 of us?
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卻不想給其他人擁有的那些屬性呢?
16:32
Will we make a society社會
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我們會把這個社會
16:35
that is more boring無聊 and more uniform制服,
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變的更千編一律、更無聊,
16:38
or more robust強大的 and more versatile多才多藝?
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還是變的更健全、更多元化呢?
16:41
These are the kinds of questions問題
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這些是我們將來
16:43
that we will have to face面對.
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必須面對的問題。
16:45
And most profoundly深深 of all,
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而更深層的問題是,
16:47
will we ever be able能夠 to develop發展 the wisdom智慧,
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我們究竟能夠成長、發展,
16:50
and to inherit繼承 the wisdom智慧,
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及傳承下去,
16:52
that we'll need to make these choices選擇 wisely明智?
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並能夠明智地做出這些選擇嗎?
16:55
For better or worse更差,
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不論是好是壞,
16:57
and sooner than you may可能 think,
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而且比我們想像來得更快,
16:59
these choices選擇 will be up to us.
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我們將會面臨這些選擇。
17:02
Thank you.
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謝謝。
17:04
(Applause掌聲)
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(掌聲)
Translated by Jefferson Wang
Reviewed by Ana Choi

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ABOUT THE SPEAKER
Harvey Fineberg - Health policy expert
Harvey Fineberg studies medical decisionmaking -- from how we roll out new medical technology, to how we cope with new illnesses and threatened epidemics.

Why you should listen

As president of the Institute of Medicine, Harvey Fineberg thinks deeply about new medicine, both its broad possibilities and the moral and philosophical questions that each new treatment brings. How do we decide which treatment to use in a tricky case -- both individually and as a community? Is it fair that the richest hospitals get the best healthcare? Who should bear the risk (and gain the reward) of trying the newest treatments?

Fineberg helped found and served as president of the Society for Medical Decision Making and also served as consultant to the World Health Organization. He was provost of Harvard from 1997 to 2001, following thirteen years as Dean of the Harvard School of Public Health. He has devoted most of his academic career to the fields of health policy and medical decision making. His past research has focused on the process of policy development and implementation, assessment of medical technology, evaluation and use of vaccines, and dissemination of medical innovations.

More profile about the speaker
Harvey Fineberg | Speaker | TED.com

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