ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com
TEDGlobal 2012

Lee Cronin: Print your own medicine

李‧克朗寧:印出你嘅專屬藥物

Filmed:
1,045,687 views

化學家李‧克朗寧(Lee Cronin)正係度研究一種3D印表機,唔係印出物體,而係能夠印出化學分子。一個讓人興奮並有潛力嘅長期應用係--用化學墨水印出專屬你嘅個人藥物。
- Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life. Full bio

Double-click the English transcript below to play the video.

00:16
Organic有機 chemists化學家 make molecules分子,
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有機化學家製造化學分子,
00:19
very complicated複雜 molecules分子,
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非常複雜嘅分子,
00:21
by chopping up a big molecule分子 into small molecules分子
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係由將大分子剪成好多小分子
00:24
and reverse反向 engineering工程.
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加上逆向工程。
00:26
And as a chemist化學家,
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而作為一個化學家,
00:27
one of the things I wanted to ask問吓 my research研究 group a couple夫婦 of years ago is,
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其中一件我幾年前想問我嘅研究團隊嘅問題就係
00:31
could we make a really cool universal普遍 chemistry化學 set設置?
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我地可唔可以整一個好型嘅「通用化學機」?
00:35
In essence本質, could we "app應用程序" chemistry化學?
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簡單來講,我地可唔可以「應用」(app) 化學?
00:40
Now what would this mean, and how would we do it?
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而家,咁樣代表咩? 而我們應該點做呢?
00:43
Well to start初時 to do this,
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好,要開始整呢個
00:45
we took a 3D printer打印機
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我地要一架3D印表機
00:47
and we started初時 to print打印 our beakers燒桮 and our test測試 tubes on one side一邊
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跟住開始一邊印我們嘅燒杯同試管,
00:51
and then print打印 the molecule分子 at the same相同 time on the other side一邊
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同時喺另一邊印出分子,
00:55
and combine結合 them together一起 in what we call reactionwarereactionware.
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然後喺我地叫反應儀嘅機裡面,將佢地結合埋一齊。
00:58
And so by printing印刷 the vessel容器 and doing the chemistry化學 at the same相同 time,
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所以藉住同時印出容器同埋做化學合成,
01:03
we may可能 start初時 to access訪問 this universal普遍 toolkit工具箱 of chemistry化學.
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我們或者可以開始進入呢個化學嘅通用工具箱。
01:08
Now what could this mean?
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咁又代表啲咩呢?
01:09
Well if we can embed嵌入 biological生物 and chemical化學 networks網絡 like a search搜尋 engine發動機,
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如果我們可以將生化網絡好似搜尋引擎咁嵌入,
01:15
so if you have a cell細胞 that's ill生病 that you need to cure治療
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咁如果你有一個你需要治療嘅細胞
01:18
or bacteria細菌 that you want to kill,
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或者你希望殺死嘅細菌,
01:20
if you have this embedded嵌入式 in your device裝置
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如果同時有呢個嵌入喺儀器裡面
01:22
at the same相同 time, and you do the chemistry化學,
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進行化學反應,
01:24
you may可能 be able to make drugs藥物 in a new新增功能 way.
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你或者可以用一個新嘅方法製造藥物。
01:28
So how are we doing this in the lab實驗室?
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咁我地點先可以喺實驗室做呢件事?
01:30
Well it requires需要 software軟件, it requires需要 hardware硬件
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佢需要軟體,亦需要硬體,
01:33
and it requires需要 chemical化學 inks油墨.
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而且需要一啲化學墨水。
01:36
And so the really cool bit is,
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所以非常酷嘅一點係
01:37
the idea想法 is that we want to have a universal普遍 set設置 of inks油墨
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整個構想係我地想有一個通用嘅墨水組
01:40
that we put out with the printer打印機,
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可以將佢放上印表機,
01:43
and you download下載 the blueprint藍圖, the organic有機 chemistry化學 for that molecule分子
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而你下載藍圖,即係個分子嘅有機化學
01:47
and you make it in the device裝置.
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然後你喺儀器中製造佢出來。
01:50
And so you can make your molecule分子 in the printer打印機 using使用 this software軟件.
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所以你可以用呢個軟體喺印表機中製造你嘅分子。
01:55
So what could this mean?
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咁代表啲咩呢?
01:58
Well, ultimately最終, it could mean that you could print打印 your own自己 medicine醫學.
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最終,佢可以表示你可以印出專屬你自己嘅藥物。
02:03
And this is what we're doing in the lab實驗室 at the moment時刻.
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而呢個亦係我地正喺實驗室做嘅。
02:05
But to take baby寶貝 steps步驟 to get there,
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不過仲有啲基本步,
02:06
first of all we want to look at drug藥物 design設計 and production生產,
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首先我們希望檢視藥物嘅設計同製造,
02:09
or drug藥物 discovery發現 and manufacturing製造.
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或者藥物嘅發現同生產。
02:12
Because if we can manufacture製造 it after we've我哋都 discovered發現 it,
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因為如果喺我們發現佢之後我們可以生產,
02:15
we could deploy部署 it anywhere地方.
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我們就可以喺任何地方調配佢。
02:17
You don't need to go to the chemist化學家 anymore.
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你們再唔須要去搵藥劑師,
02:19
We can print打印 drugs藥物 at pointD of need.
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我們可以喺需要嘅時候印出藥物,
02:22
We can download下載 new新增功能 diagnostics診斷.
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我們可以下載新嘅診斷。
02:24
Say a new新增功能 super超級 bug錯誤 has emerged出現.
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例如話有一種新嘅超級細菌出現,
02:26
You put it in your search搜尋 engine發動機,
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你就將佢放入你嘅搜尋引擎,
02:28
and you create創建 the drug藥物 to treat治療 the threat威脅.
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然後你就創造出治療呢個威脅嘅藥。
02:31
So this allows允許 you on-the-fly在飛 molecular分子 assembly裝配.
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因此佢就允許你快速咁做同步分子組裝。
02:35
But perhaps或者 for me the core核心 bit going into the future未來
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但係可能對我來講展望未來最核心嘅構想
02:38
is this idea想法 of taking採取 your own自己 stem cells細胞,
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係用你自己嘅幹細胞
02:41
with your genes基因 and your environment環境,
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同埋你嘅基因以及你嘅環境,
02:43
and you print打印 your own自己 personal medicine醫學.
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你就可以印出屬於你個人嘅藥物。
02:46
And if that doesn't seem好似 fanciful幻想 enough,
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如果咁樣睇落都唔夠吸引,
02:48
where do you think we're going to go?
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你想我地仲能夠去到邊呢?
02:50
Well, you're going to have your own自己 personal matter個問題 fabricator製造商.
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好喇,你地將會有你地嘅個人物質製造機。
02:55
Beam me up, Scotty斯科特.
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史考提,將我傳送上去啦!
02:57
(Applause掌聲)
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(掌聲)
Translated by Yuen Lam Tsang
Reviewed by Michelle Ho

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ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com

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