TEDxBoston 2011
Richard Resnick: Welcome to the genomic revolution
Richard Resnick: Dobro došli u genomičku revoluciju
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U ovom dostupnom govoru s TedxBoston-a, Richard Resnick pokazuje kako jeftino i brzo sekvencioniranje genoma može potpuno promjeniti zdravstvenu zaštitu (uključujući zdravstevno osiguranje i politiku).
Richard Resnick - Entrepreneur
Richard Resnick is on the front lines of the business of genomes, as CEO of GenomeQuest, a maker of genomic software. Full bio
Richard Resnick is on the front lines of the business of genomes, as CEO of GenomeQuest, a maker of genomic software. Full bio
Double-click the English transcript below to play the video.
00:15
Ladies and gentlemen,
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Dame i gospodo,
00:17
I present to you the human genome.
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predstavljam vam ljudski genom.
00:20
(Applause)
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(Pljesak)
00:23
Chromosome one, top left.
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Prvi kromosom u gornjem lijevom kutu.
00:25
Bottom right are the sex chromosomes.
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U donjem desnom kutu su spolni kromosomi .
00:27
Women have two copies of that big X chromosome;
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Žene imaju dvije kopije velikog X kromosoma,
00:29
men have the X
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muškarci imaju X,
00:31
and, of course, that small copy of the Y.
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i naravno, jedan mali Y kromosom.
00:33
Sorry boys, but it's just a tiny little thing that makes you different.
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Žao mi je, dečki, ali od žena vas čini različitim samo sićušna malena stvarčica.
00:37
So if you zoom in on this genome,
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Dakle, ako povećate prikaz ovog genoma,
00:40
then what you see, of course, is this double helix structure --
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primjetit ćete oblik dvostruke zavojnice --
00:43
the code of life spelled out with these four biochemical letters,
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životni kod sastoji se od ova četiri biokemijska slova,
00:45
or we call them bases, right:
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kojima nazivamo baze.
00:47
A, C, G and T.
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To su A, C, G i T.
00:49
How many are there in the human genome? Three billion.
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Koliko ih ima u ljudskom genomu? Tri milijarde.
00:51
Is that a big number?
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Je li to velik broj?
00:53
Well, everybody can throw around big numbers.
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Pa, svatko se može razbacivati velikim brojevima.
00:55
But in fact, if I were to place one base
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Ali, zapravo, ako bismo mogli zamisliti jednu bazu
00:57
on each pixel of this 1280 by 800 resolution screen,
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kao jedan pixel na ovom ekranu rezolucije 1.280x800,
01:00
we would need 3,000 screens to take a look at the genome.
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bilo bi nam potrebno 3.000 takvih ekrana da bismo mogli imati pregled cijeloga genoma.
01:03
So it's really quite big.
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Znači, prilično je to velika brojka.
01:05
And perhaps because of its size,
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Možda je baš u pitanju veličina,
01:07
a group of people -- all, by the way, with Y chromosomes --
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zbog čega je grupa ljudi -- od kojih svi, kad smo već kod toga, posjeduju Y kromosom --
01:10
decided they would want to sequence it.
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odlučila sekvencionirati genom.
01:12
(Laughter)
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(Smijeh)
01:14
And so 15 years, actually, and about four billion dollars later,
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I tako, 15 godina i četiri milijarde dolara kasnije,
01:17
the genome was sequenced and published.
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genom je sekvencioniran i objavljen.
01:19
In 2003, the final version was published, and they keep working on it.
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U 2003.godini objavljena je završna verzija, ali i dalje se nastavlja rad na tom projektu.
01:22
That was all done on a machine that looks like this.
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Cijeli proces sekvencioniranja učinjen je na uređaju koji izgleda ovako.
01:24
It costs about a dollar for each base --
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Dođe otprilike jedan dolar po bazi --
01:26
a very slow way of doing it.
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i to je vrlo spor način sekvencioniranja.
01:28
Well folks, I'm here to tell you
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Dakle, ljudi, danas sam ovdje kako bih vam rekao
01:30
that the world has completely changed
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kako se svijet potpuno promjenio,
01:32
and none of you know about it.
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a nitko od vas ne zna za to.
01:34
So now what we do is we take a genome,
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Sada zapravo, uzmemo genom,
01:36
we make maybe 50 copies of it,
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napravimo 50-ak kopija tog genoma,
01:38
we cut all those copies up into little 50-base reads,
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isiječemo sve te kopije u male 50-bazne dijelove,
01:41
and then we sequence them, massively parallel.
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i sekvencioniramo ih većinom paralelno.
01:43
And then we bring that into software,
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Onda rezultat unesemo u softver,
01:45
and we reassemble it and we tell you what the story is.
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i ponovno ga sastavimo, i proučimo.
01:47
And so just to give you a picture of what this looks like,
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Samo da vam dam sliku kako to otprilike izgleda.
01:50
the Human Genome Project: 3 gigabases, right.
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Projekt Ljudski genom: 3 gigabaze.
01:52
One run on one of these machines:
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Pri radu ovog stroja
01:54
200 gigabases in a week.
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možemo sekvencionirati 200 gigabaza tjedno.
01:57
And that 200 is going to change to 600 this summer,
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Taj broj od 200 gigabaza, promjenit će se u 600 ovog ljeta,
02:00
and there's no sign of this pace slowing.
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a nema znakova da će se taj proces napredovanja i ubrzavanja usporiti.
02:03
So the price of a base, to sequence a base,
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Tako je cijena za sekvencioniranje baze
02:06
has fallen 100 million times.
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pala 100 milijuna puta.
02:09
That's the equivalent of you filling up your car with gas in 1998,
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To je ekvivalentno punjenju automobila plinom u 1998.godini,
02:12
waiting until 2011,
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da biste čekali do 2011.
02:14
and now you can drive to Jupiter and back twice.
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kako biste se odvezli od Jupitera i nazad dva puta.
02:16
(Laughter)
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(Smijeh)
02:21
World population,
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Svjetska populacija,
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PC placements,
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PC prostori,
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the archive of all the medical literature,
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arhiva cijele medicinske literature,
02:28
Moore's law,
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Mooreov zakon,
02:30
the old way of sequencing, and here's all the new stuff.
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stari način sekvencioniranja i sve ove novine.
02:33
Guys, this is a log scale;
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Ljudi, ovo je logaritamska skala,
02:35
you don't typically see lines that go up like that.
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obično se ne viđaju tako strme skale koje idu prema gore.
02:38
So the worldwide capacity to sequence human genomes
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Dakle, svjetski kapacitet za sekvencioniranje ljudskih genoma
02:41
is something like 50,000 to 100,000 human genomes this year.
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je otprilike od 50.000 do 100.000 genoma godišnje.
02:44
And we know this based on the machines that are being placed.
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Znamo to na temelju broja strojeva koji postoje.
02:47
This is expected to double, triple or maybe quadruple
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Očekuje se da će se taj broj povećati dva, tri ili čak četiri puta
02:50
year over year for the foreseeable future.
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svake godine u doglednoj budućnosti.
02:52
In fact, there's one lab in particular
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Zapravo, postoji jedan laboratorij
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that represents 20 percent of all that capacity.
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u kojem se odrađuje 20 posto svih kapaciteta za sekvencioniranje genoma.
02:57
It's called the Beijing Genomics Institute.
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Zove se Pekinški institut genomike.
03:00
The Chinese are absolutely winning this race to the new Moon, by the way.
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Kinezi, kad smo već kod toga, apsolutno vode u ovoj utrci do 'novog mjeseca'.
03:04
What does this mean for medicine?
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Kakvo to značenje ima za medicinu?
03:06
So a woman is age 37.
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Dakle, žena od 37 godina.
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She presents with stage 2 estrogen receptor-positive breast cancer.
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Ona dolazi s drugom fazom raka dojke pozitivnog na estrogenske receptore.
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She is treated with surgery, chemotherapy and radiation.
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Liječi se kirurški, kemoterapijom i zračenjem.
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She goes home.
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Odlazi kući.
03:17
Two years later, she comes back with stage three C ovarian cancer.
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Dvije godine kasnije, vraća se s trećom fazom karcinoma jajnika.
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Unfortunately, treated again with surgery and chemotherapy.
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Nažalost, opet ju se podvrgava kirurškim zahvatima i kemoterapiji.
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She comes back three years later at age 42
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Ponovno dolazi tri godine poslije u dobi od 42 godine
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with more ovarian cancer, more chemotherapy.
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s još više raka jajnika, više kemoterapije.
03:28
Six months later,
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Šest mjeseci poslije,
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she comes back with acute myeloid leukemia.
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dolazi s akutnom mijeloidnom leukemijom.
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She goes into respiratory failure and dies eight days later.
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Dolazi do zatajenja respiratornog sustava i osam dana kasnije umire.
03:37
So first, the way in which this woman was treated, in as little as 10 years,
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Dakle, ovaj način liječenja žene, za desetak godina
03:40
will look like bloodletting.
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djelovat će poput puštanja krvi.
03:43
And it's because of people like my colleague, Rick Wilson,
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I to zato što su ljudi, poput mojega kolege, Ricka Wilsona,
03:45
at the Genome Institute at Washington University,
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koji radi u Genome Institute-u na sveučilištu u Washingtonu,
03:48
who decided to take a look at this woman postmortem.
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odlučili pregledati tu ženu poslije smrti.
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And he sequenced, he took skin cells, healthy skin,
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Uzeo je neke zdrave stanice kože
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and cancerous bone marrow,
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i nekoliko kancerogenih stanica koštane srži,
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and he sequenced the whole genomes of both of them
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te sekvencionirao cijeli genom obiju vrsta stanica
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in a couple of weeks, no big deal.
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u nekoliko tjedana, što nije velika stvar.
04:00
And then he compared those two genomes in software,
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Onda je usporedio ta dva genoma u softveru,
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and what he found, among other things,
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i našao je, izmeđuostalog,
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was a deletion, a 2,000-base deletion
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deleciju -- deleciju 2.000 baza
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across three billion bases
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-- u cijelom genomu od tri milijarde baza --
04:08
in a particular gene called TP53.
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u jednom određenom genu koji se zove TP53.
04:10
If you have this deleterious mutation in this gene,
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Ako imate štetnu mutaciju u ovom genu,
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you're 90 percent likely to get cancer in your life.
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90 posto je vjerojatnost da ćete oboljeti od karcinoma tijekom svojega života.
04:16
So unfortunately, this doesn't help this woman,
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Nažalost, to neće pomoći toj ženi,
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but it does have severe, profound if you will,
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ali imat će ozbiljne implikacije
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implications to her family.
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za njezinu obitelj.
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I mean, if they have the same mutation,
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Mislim, ako članovi njezine obitelji imaju istu tu mutaciju
04:25
and they get this genetic test, and they understand it,
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i naprave ovaj genetski test, te razumiju što takav rezultat pretraga za njih znači,
04:28
then they can go and get regular screens, and they can catch cancer early
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ići će na česte preglede i na taj način mogu rak otkriti u ranoj fazi
04:31
and potentially live a significantly longer life.
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i uz to imati veće šanse za znatno duži životni vijek.
04:33
Let me introduce you now to the Beery twins,
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Dopustite mi predstaviti vam blizance Beery,
04:35
diagnosed with cerebral palsy at the age of two.
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kojima je dijagnosticirana cerebralna paraliza kada su imali dvije godine.
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Their mom is a very brave woman
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Njihova je majka bila vrlo hrabra žena,
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who didn't believe that the symptoms weren't matching up,
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koja nije vjerovala dijagnozi jer se sistemi nisu poklapali sa simptomima bolesti,
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and through some heroic efforts and a lot of Internet searching,
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i uz pomoć herojskih napora i jako puno pretraživanja po internetu,
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she was able to convince the medical community
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uspjela je uvjeriti medicinsku zajednicu
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that, in fact, they had something else.
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da boluju od nečega drugoga.
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What they had was dopa-responsive dystonia.
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Imali su distoniju koja reagira na dopu.
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And so they were given L-Dopa,
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Tako da su se primanjem L-Dopa,
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and their symptoms did improve,
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njihovi simptomi znatno poboljšali,
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but they weren't totally asymptomatic.
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ali nisu ostali bez simptoma.
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Significant problems remained.
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Značajan je problem ostao.
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Turns out the gentleman in this picture is a guy named Joe Beery,
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Gospodin na ovoj slici je čovjek zvan Joe Beery,
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who was lucky enough to be the CIO
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sretnik je koji je CIO
05:03
of a company called Life Technologies.
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tvrtke koja se zove Life Technologies.
05:05
They're one of the two companies
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To je jedna od dvije kompanije
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that makes these massive whole genome sequencing tools.
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koja se bavi masovnim sekvencioniranjem ljudskih genoma.
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And so what he did was he got his kids sequenced.
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On je sekvencionirao genome svoje djece.
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And what they found was a series of mutations in a gene called SPR,
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Ono što je pronašao su bile serije mutacija u genu SPR,
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which is responsible for producing serotonin, among other things.
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koji je odgovoran za proizvodnju serotonina, uz neke ostale funkcije.
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So on top of L-Dopa, they gave these kids a serotonin precursor drug,
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Tako da je uz L-Dopa, terapija pojačana serotonin-prekursorskim lijekovima
05:23
and they're effectively normal now.
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i sada su potpuno bez simptoma.
05:25
Guys, this would never have happened without whole genome sequencing.
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Ovo se nikada ne bi dogodilo bez potpunog sekvencioniranja genoma.
05:28
And at the time -- this was a few years ago -- it cost $100,000.
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U to vrijeme -- to je bilo prije nekoliko godina -- koštalo je oko 100.000 dolara.
05:30
Today it's $10,000. Next year it's $1,000.
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Danas se za sekvencioniranje mora izdvojiti 10.000 dolara.
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The year after it's $100, give or take a year.
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Iduće godine će biti 1.000. Godina nakon nje, 100 dolara, godina prije ili poslije.
05:34
That's how fast this is moving.
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Toliko brzo napreduje taj odsječak medicine.
05:36
So here's little Nick --
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Dakle, ovo je mali Nick --
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likes Batman and squirt guns.
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voli Batmana i oružje.
05:41
And it turns out Nick shows up at the children's hospital
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Nick se u dječjoj bolnici pojavio s
05:44
with this distended belly like a famine victim.
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proširenim trbuhom, kakvoga imaju inače žrtve gladi.
05:46
And it's not that he's not eating,
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Razlog tome nije glad,
05:48
it's that when he eats, his intestine basically opens up
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već to što, kada jede -- njegovi se probavni organi jednostavno otvore
05:50
and feces spill out into his gut.
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i neprobavljena hrana odlazi direktno u crijeva.
05:52
So a hundred surgeries later,
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I tako, sto operacija poslije,
05:54
he looks at his mom and says, "Mom,
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on pogleda majku i kaže: ''Mama,
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please pray for me. I'm in so much pain."
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molim te, moli se za mene. Užasno me boli'.'
06:00
His pediatrician happens to have a background in clinical genetics
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Njegov pedijatar ima iskustva u kliničkoj genetici,
06:03
and he has no idea what's going on,
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no ne razumije što se događa,
06:05
but he says, "Let's get this kid's genome sequenced."
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ali kaže: “Hajdemo sekvencionirati dječakov genom”.
06:07
And what they find is a single-point mutation
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I ono što su pronašli bila je točkasta mutacija
06:09
in a gene responsible for controlling programmed cell death.
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u genu odgovornom za kontrolu programirane stanične smrti (apoptoze).
06:12
So the theory is that he's having some immunological reaction
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Znači, teorija je da on ima nekakvu imunološku reakciju
06:15
to what's going on to the food essentially,
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na ono što se u organizmu događa s hranom,
06:18
and that's a natural reaction, which causes some programmed cell death.
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a to je prirodna reakcija koja uzrokuje neke apoptoze.
06:21
But the gene that regulates that down is broken.
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Ali gen koji regulira tu reakciju je “pokvaren”.
06:23
And so this informs, among other things, of course,
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Ovo nas upućuje, između ostalih stvari, naravno,
06:25
a treatment for bone marrow transplant, which he undertakes.
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na tretman transplantacije koštane srži, kojem se dječak podvrgava.
06:28
And after nine months of grueling recovery,
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I nakon devet mjeseci napornog oporavka,
06:30
he's now eating steak with A1 sauce.
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on sada jede odrezak s “A1 umakom”.
06:32
(Laughter)
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(Smijeh)
06:34
The prospect of using the genome
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Mogućnost korištenja genoma
06:36
as a universal diagnostic
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kao univerzalne dijagnoze
06:38
is upon us today.
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je pred nama.
06:40
Today, it's here.
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Danas je to moguće.
06:42
And what it means for all of us
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I to znači
06:44
is that everybody in this room could live an extra five, 10, 20 years
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da bi svaka osoba u ovoj prostoriji mogla živjeti dodatnih pet, 10 ili 20 godina
06:47
just because of this one thing.
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samo zbog ove mogućnosti.
06:49
Which is a fantastic story,
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Ovo je fantastična priča,
06:51
unless you think about humanity's footprint on the planet
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ukoliko ne razmišljate o proizvodnji hrane
06:54
and our ability to keep up food production.
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isključivo „ljudskom rukom“.
06:56
So it turns out
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Jer se ista tehnologija
06:58
that the very same technology
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koristi za uzgoj
07:00
is also being used to grow new lines
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novih linija
07:02
of corn, wheat, soybean and other crops
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kukuruza, pšenice, soje i drugih usjeva
07:05
that are highly tolerant of drought, of flood,
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koji su visoko tolerantni na sušu, poplave,
07:07
of pests and pesticides.
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štetnike i pesticide.
07:09
Now look, as long as we continue to increase the population,
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Gledajte, dokle god nastavljamo povećavati populaciju,
07:12
we're going to have to continue to grow and eat genetically modified foods,
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morat ćemo nastaviti s uzgojem i konzumiranjem genetski modificirane hrane
07:15
and that's the only position that I'll take today.
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i to je stajalište za koje se ja danas zauzimam.
07:18
Unless there's anybody in the audience
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Osim ako ne postoji netko u publici
07:20
that would like to volunteer to stop eating?
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tko bi volio dobrovoljno prestati jesti?
07:22
None, not one.
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Ne, nitko.
07:24
This is a typewriter,
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Ovo je pisaći stroj,
07:26
a staple of every desktop for decades.
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glavni stroj svake radne površine desetljećima.
07:29
And in fact, the typewriter was essentially deleted by this thing.
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U biti, pisaći je stroj prvotno zamjenjen ovim uređajem.
07:33
And then more general versions of word processors came about.
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Tada dolaze druge verzije procesora.
07:36
But ultimately, it was a disruption on top of a disruption.
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Ali u konačnici, prijelom nad svime
07:39
It was Bob Metcalfe inventing the Ethernet
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bio je Bob Metcalfe koji je izumio „Ethernet“
07:41
and the connection of all these computers
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i omogućio povezivanje svih ovih kompjutera,
07:43
that fundamentally changed everything.
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koje je sve iz temelja promijenilo.
07:45
And suddenly we had Netscape, and we had Yahoo
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I odjednom, imali smo Netscape, imali smo Yahoo,
07:48
and we had, indeed, the entire dotcom bubble.
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imali smo cijelu dot.com zavrzlamu.
07:51
(Laughter)
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(Smijeh)
07:54
Not to worry though,
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Ne brinite,
07:56
that was quickly rescued by the iPod, Facebook
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i to sve su brzo zamijenili iPod, Facebook
07:58
and, indeed, angry birds.
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i ljute ptice.
08:00
(Laughter)
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(Smijeh)
08:02
Look, this is where we are today.
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Gledajte, ovo je mjesto na kojem smo danas.
08:05
This is the genomic revolution today. This is where we are.
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Ovo je revolucija genoma danas. Ovako danas stojimo.
08:07
So what I'd like you to consider is:
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Volio bih da razmislite o ovome:
08:09
What does it mean
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Što bi značilo
08:11
when these dots don't represent the individual bases of your genome,
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kada ove točkice ne bi predstavljale pojedinačne baze vašeg genoma,
08:14
but they connect to genomes all across the planet?
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već bi bile povezane sa svim genomima diljem planeta?
08:17
So I just recently had to buy life insurance.
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Nedavno sam kupovao životno osiguranje.
08:19
And I was required to answer:
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I morao sam odgovoriti na pitanje s
08:21
A. I have never had a genetic test, B. I've had one, here you go,
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A. nikad nisam napravio genetički test, B. testiran sam, izvolite rezultate
08:24
and C. I've had one and I'm not telling.
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ili C. testiran sam, ali ne želim podijeliti rezultat.
08:26
Thankfully, I was able to answer A,
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Hvala Bogu, mogao sam odabrati odgovor pod A
08:28
and I say that honestly in case my life insurance agent is listening.
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i to je istinit odgovor, u slučaju da me moj agent za osiguranje sada sluša.
08:31
But what would have happened if I had said C?
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Ali što bi se dogodilo da sam odgovorio s C?
08:34
Consumer applications for genomics, they will flourish.
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Potrošačke aplikacije vezane za genomiku, one će procvasti.
08:36
Do you want to see whether you're genetically compatible
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Želite vidjeti jeste li genetički kompatibilni
08:38
with your girlfriend? Sure.
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sa svojom djevojkom? Svakako.
08:40
DNA sequencing on your iPhone? There's an app for that.
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DNK sekvenciranje na vašem iPhoneu? Evo aplikacije.
08:43
(Laughter)
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(Smijeh)
08:45
Personalized genomic massage anyone?
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Personalizirana genomska masaža, možda?
08:48
There's already a lab today
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Danas već imamo laboratorij
08:50
that tests for allele 334 of the AVPR1 gene,
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koji radi testove na alelu 334 gena AVPR1,
08:52
the so-called cheating gene.
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takozvanog „gena za varanje“.
08:54
So anybody who's here today with your significant other,
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Zato se svi vi koji ste danas ovdje sa svojom boljom polovicom
08:58
just turn over to them and swab their mouth,
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jednostavno okrenite prema njima i uzmite obris iz usta,
09:00
send it to the lab and you'll know for sure.
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pošaljite u laboratorij i znat ćete za sigurno.
09:02
(Laughter)
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(Smijeh)
09:04
Do you really want to elect a president
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Želite li uistinu glasovati za predsjednika
09:06
whose genome suggests cardiomyopathy?
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čiji genom otkriva kardiomiopatiju?
09:08
Now think of it, it's 2016
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Sad razmislite o ovome, godina je 2016.
09:10
and the leading candidate releases
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i vodeći kandidat objavljuje
09:11
not only her four years of back tax returns,
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ne samo svoje četiri godine plaćanja i povrata poreza,
09:13
but also her personal genome.
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već i svoj osobni genom.
09:15
And it looks really good.
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I on izgleda jako dobro.
09:17
And then she challenges all of her competitors to do the same.
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A tada izaziva sve ostale kandidate da učine isto.
09:19
Do you think that's not going to happen?
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Mislite li da se to neće dogoditi?
09:21
Do you think it would have helped John McCain?
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Mislite li da je to moglo pomoći Johnu McCainu?
09:23
(Laughter)
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(Smijeh)
09:25
How many people in the audience
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Koliko se ljudi u publici
09:27
have the last name Resnick like me? Raise your hand.
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preziva Resnick poput mene? Podignite ruku.
09:29
Anybody? Nobody.
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Itko? Nitko.
09:31
Typically, there's one or two.
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Obično postoji jedan ili dva.
09:33
So my father's father was one of 10 Resnick brothers.
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Moj je djed bio jedan od desetoro braće Resnick.
09:35
They all hated each other.
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I svi su se međusobno mrzili.
09:37
And they all moved to different parts of the planet.
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Svaki se preselio na drugi dio planeta.
09:39
So it's likely
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Zato je vrlo vjerojatno
09:41
that I'm related to every Resnick that I ever meet, but I don't know.
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da sam u rodu sa svakim Resnickom kojeg sam ikad upoznao, samo ja to ne znam.
09:44
But imagine if my genome were deidentified, sitting in software,
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Ali zamislite kako bi bilo kad bi moj genom bio identificiran, ubačen u softver,
09:47
and a third cousin's genome was also sitting there,
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softver u kojemu se nalazi i genom mog bratića u trećem koljenu.
09:49
and there was software that could compare these two
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I taj isti softver može usporediti ova dva genoma
09:51
and make these associations.
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i otkriti njihovu povezanost.
09:53
Not hard to imagine. My company has software that does this right now.
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Nije to tako teško za zamisliti. Moje poduzeće ima softver koji to već radi.
09:56
And so imagine one more thing:
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I zamislite još jednu stvar:
09:58
that that software is able to ask both parties for mutual consents,
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zamislite da taj softver može upitati obje strane za međusobnu suglasnost,
10:01
"Would you be willing to meet your third cousin?"
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„ Želite li upoznati svog bratića u trećem koljenu?“
10:03
And if we both say yes,
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I ako oboje kažemo „DA“
10:05
voila! Welcome to chromosomally LinkedIn.
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-- voila! Dobrodošli na kromosomski Linkedln.
10:07
(Laughter)
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(Smijeh)
10:11
Now this is probably a good thing, right?
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Ovo je vjerojatno dobra stvar, zar ne?
10:13
You have bigger clan gatherings and so on.
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Imat ćete veća obiteljska okupljanja i sve to.
10:15
But maybe it's a bad thing as well.
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Ali, možda je, ujedno, i loša stvar.
10:17
How many fathers in the room? Raise your hands.
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Koliko očeva imamo u prostoriji? Podignite ruke.
10:19
Okay, so experts think that one to three percent of you
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Ok, stručnjaci procjenjuju da jedan do tri posto vas
10:22
are not actually the father of your child.
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nije biološki otac svog djeteta.
10:24
(Laughter)
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(Smijeh)
10:26
Look --
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Pogledajte.
10:28
(Laughter)
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(Smijeh)
10:32
These genomes, these 23 chromosomes,
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Ovi genomi, ova 23 kromosoma,
10:35
they don't in any way represent the quality of our relationships
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ni na koji način ne predstavljaju kvalitetu naših odnosa
10:38
or the nature of our society -- at least not yet.
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ili prirodu našeg društva -- barem ne još.
10:40
And like any new technology,
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I kao kod svake nove tehnologije,
10:42
it's really in humanity's hands
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u ljudskim je rukama
10:44
to wield it for the betterment of mankind, or not.
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hoćemo li ju iskoristiti za poboljšanje čovječanstva ili ne.
10:47
And so I urge you all to wake up and to tune in
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I zato vas sve potičem da se probudite, uključite
10:50
and to influence the genomic revolution that's happening all around you.
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i utječete na genomsku revoluciju koja se događa svuda oko vas.
10:53
Thank you.
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Hvala vam.
10:55
(Applause)
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(Pljesak)
ABOUT THE SPEAKER
Richard Resnick - EntrepreneurRichard Resnick is on the front lines of the business of genomes, as CEO of GenomeQuest, a maker of genomic software.
Why you should listen
Richard Resnick is CEO of GenomeQuest , a company that builds software to support genomic medicine -- research and individualized treatments that take advantage of cheap and accessible genome processing. He was previously CEO of Mosaic Bioinformatics; before becoming a bio-entrepreneur, he was a member of the Human Genome Project under Eric Lander at MIT.
Richard Resnick | Speaker | TED.com