Paula Hammond: A new superweapon in the fight against cancer
Paula Hammond: Új szuperfegyver a rák elleni harcban
Paula Hammond, head of MIT's Department of Chemical Engineering, is developing new technologies to kill cancer cells. Full bio
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back over and over again,
and drug-resistant ones,
is használjuk ellenük.
forms of cancer.
how to address relatively well
drugs and surgery.
beavatkozások által.
very aggressive forms of cancer
from a genetic mutation.
inside these tumor cells
and unimagined modes of survival,
in which a gene allows a cell,
spits out the drug.
of the many genetic tricks
with incredible superpowers.
mode of attack.
egy új, hatásos támadási mód.
known as siRNA.
can turn off a specific gene
these gene blockers in medicine.
az orvostanban.
or our tissues,
through its journey through the body
inside the cancer cell.
with siRNA, the gene blocker,
to get through the bloodstream,
to penetrate the tumor tissue,
to be taken up inside the cancer cell.
the size of a human hair.
at how we can build this nanoparticle.
with the nanoparticle core.
the chemotherapy drug.
actually end the tumor cell's life.
negatively charged,
of positively charged polymer.
molecules stick together
with a protective layer
from degrading in the bloodstream.
we have to think about.
obstacle of all.
needs to be targeted,
to the supervillain cells
immune-defense system:
is considered a foreign object.
past the tumor defense system.
a tumor védelmi rendszerén át.
of getting rid of the foreign object
az idegen anyagoktól megszabadulni akaró
negatively charged layer
még egy negatív töltésű réteget
of the naturally charged,
that resides in our body.
amely megtalálható bennünk.
around the nanoparticle
vízmolekula-felhőt alkot,
cloaking effect.
the nanoparticle
hosszan és messze utazzon,
takes up the nanoparticle,
inside the cancer cell
and block those survival genes.
those genetic superpowers.
with no special defenses.
comes out of the core
cleanly and efficiently.
tisztán és hatékonyan.
different kinds of mutations,
particles in animals
of triple-negative breast cancer.
nagyon agresszív formájával.
exhibits the gene
as soon as it is delivered.
it "dox" -- is the cancer drug
a szer,
for breast cancer.
with a dox core, dox only.
over a period of two weeks.
our combination superweapon.
against the chemo pump,
did the tumors stop growing,
is that it can be personalized.
személyre szabott lehet.
and tumor defense mechanisms.
into the nanoparticle core.
a tesztelések módjára,
tumor genetic types,
can benefit from this strategy
kinek előnyös ez,
a special chord with me.
at very late stages,
fedezik fel,
of genetic mutations.
for 75 percent of patients.
in a drug-resistant form.
ellenálló a szerekre.
supervillains out there.
Mimi, and her daughter, Paige.
by the optimism and strength
about the different technologies
about these efforts
really elegant science.
the power of engineering
move forward in their careers,
health problems in the world --
disorders, infectious disease --
rendellenességek, fertőzések –
found a way to open doors for me,
ajtókat nyitott számomra,
that of molecules,
ABOUT THE SPEAKER
Paula Hammond - Medical researcher and educatorPaula Hammond, head of MIT's Department of Chemical Engineering, is developing new technologies to kill cancer cells.
Why you should listen
Professor Paula T. Hammond is the Head of the Department of Chemical Engineering and David H. Koch Chair Professor in Engineering at the Massachusetts Institute of Technology (MIT). She is a member of MIT's Koch Institute for Integrative Cancer Research, the MIT Energy Initiative and a founding member of the MIT Institute for Soldier Nanotechnology. She has recently been named the new head of the Department of Chemical Engineering (ChemE). She is the first woman and the first person of color appointed to the post. She also served as the Executive Officer (Associate Chair) of the Chemical Engineering Department (2008-2011).
Professor Hammond was elected into the 2013 Class of the American Academy of Arts and Sciences. She is also the recipient of the 2013 AIChE Charles M. A. Stine Award, which is bestowed annually to a leading researcher in recognition of outstanding contributions to the field of materials science and engineering, and the 2014 Alpha Chi Sigma Award for Chemical Engineering Research. She was also selected to receive the Department of Defense Ovarian Cancer Teal Innovator Award in 2013. She has been listed in the prestigious Highly Cited Researchers 2014 list, published by Thomson Reuters in the Materials Science category. This list contains the world's most influential researchers across 21 scientific disciplines based on highly cited papers in the 2002-2012 period. She is also included in the report: The World's Most Influential Scientific Minds 2014.
Professor Hammond serves as an Associate Editor of the American Chemical Society journal, ACS Nano. She has published over 250 scientific papers and holds over 20 patents based on her research at MIT. She was named a Fellow of the American Physical Society, the American Institute of Biological and Medical Engineers, and the American Chemical Society Polymer Division. In 2010, she was named the Scientist of the Year by the Harvard Foundation.
Professor Hammond received her B.S. in Chemical Engineering from MIT in 1984, and her M.S. from Georgia Tech in 1988 and earned her Ph.D. in 1993 from MIT.
Paula Hammond | Speaker | TED.com