ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com
TEDGlobal 2012

Lee Cronin: Print your own medicine

Lee Cronin: Atsispausdink vaistus sau

Filmed:
1,045,687 views

Chemikas Lee Cronin kuria 3D spausdintuvą, kuris vietoje objektų galėtų spausdinti molekules. Įdomus ir potencialus ilgalaikis pritaikymo būdas: panaudojant chemines jungtis, atsispausdinti vaistus sau pačiam.
- Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life. Full bio

Double-click the English transcript below to play the video.

00:16
OrganicOrganinių chemistschemikai make moleculesmolekulės,
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Organinės chemijos mokslininkai gamina molekules,
00:19
very complicatedsudėtingas moleculesmolekulės,
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labai sudėtingas molekules,
00:21
by choppingsmulkinimas up a bigdidelis moleculemolekulė into smallmažas moleculesmolekulės
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sukapodami dideles į mažesnes,
00:24
and reverseatvirkštinis engineeringinžinerija.
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ir taip panaudodami jas gamybai.
00:26
And as a chemistchemikas,
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Kaip chemikas,
00:27
one of the things I wanted to askpaklausk my researchtyrimai groupgrupė a couplepora of yearsmetai agoprieš is,
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prieš porą metų, dirbdamas kartu su savo tyrimų grupe, norėjau paklausti vieno dalyko,
00:31
could we make a really coolSaunus universalUniversalus chemistrychemija setnustatyti?
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ar galėtume sukurti universalų chemijos rinkinį?
00:35
In essenceesmė, could we "appapp" chemistrychemija?
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Iš esmės, ar galėtume chemiją paversti programėlėmis?
00:40
Now what would this mean, and how would we do it?
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Tačiau ką gi tai reikštų ir kaip tai padarytume?
00:43
Well to startpradėti to do this,
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Iš pat pradžių
00:45
we tookpaėmė a 3D printerspausdintuvas
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mes paėmėme 3D spausdintuvą
00:47
and we startedprasidėjo to printspausdinti our beakerslaboratorinės stiklinės and our testbandymas tubesvamzdeliai on one sidepusė
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ir ėmėme spausdinti savo laužiklius ir eksperimentinius mėgintuvėlius vienoje pusėje,
00:51
and then printspausdinti the moleculemolekulė at the sametas pats time on the other sidepusė
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ir tuo pat metu spausdinti molekules kitoje pusėje,
00:55
and combinesujungti them togetherkartu in what we call reactionwarereactionware.
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ir sujungti juos į tai, ką pavadinome reakcijų įrankiais.
00:58
And so by printingspausdinimas the vessellaivas and doing the chemistrychemija at the sametas pats time,
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Taigi tuo pat metu, kai spausdiname indus ir užsiimame chemija,
01:03
we mayGegužė startpradėti to accessprieiga this universalUniversalus toolkitįrankių rinkinys of chemistrychemija.
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galime pradėti naudoti šį universalųjį chemijos rinkinį.
01:08
Now what could this mean?
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Ir ką gi tai galėtų reikšti?
01:09
Well if we can embedįdėti biologicalbiologinis and chemicalcheminė medžiaga networkstinklai like a searchPaieška enginevariklis,
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Na, jei galėtume įtraukti biologinius ir cheminius tinklus kaip paieškos sistemą,
01:15
so if you have a cellląstelė that's illnesveikas that you need to cureišgydyti
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tada, turėdami ląstelę, kuri serga ir kurią reikia gydyti,
01:18
or bacteriabakterijos that you want to killnužudyti,
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ar bakteriją, kurią norime nužudyti,
01:20
if you have this embeddedįterptas in your deviceprietaisas
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ir jeigu tuo pat metu tai būtų įtraukta į tavo įrenginį,
01:22
at the sametas pats time, and you do the chemistrychemija,
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užsiimant chemija,
01:24
you mayGegužė be ablegalingas to make drugsnarkotikai in a newnaujas way.
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galbūt būtų galima kurti vaistus nauju būdu.
01:28
So how are we doing this in the lablaboratorija?
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Taigi, kaip mes tai atliekame laboratorijoje?
01:30
Well it requiresreikalauja softwareprograminė įranga, it requiresreikalauja hardwaretechninė įranga
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Na, tam reikia programinės ir techninės įrangos
01:33
and it requiresreikalauja chemicalcheminė medžiaga inksrašalas.
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ir, be abejo, cheminių sąryšių.
01:36
And so the really coolSaunus bitšiek tiek is,
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Ir iš tikrųjų įdomu yra tai,
01:37
the ideaidėja is that we want to have a universalUniversalus setnustatyti of inksrašalas
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kad mes norime sukurti universalių sąryšių rinkinį,
01:40
that we put out with the printerspausdintuvas,
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kurį galėtume įtraukti į spausdintuvą,
01:43
and you downloadparsisiųsti the blueprintprojektas, the organicekologiškas chemistrychemija for that moleculemolekulė
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ir tada, parsisiuntę aprašą, organinės chemijos nurodymus tai molekulei
01:47
and you make it in the deviceprietaisas.
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galėtume patalpinti juos į įrenginį.
01:50
And so you can make your moleculemolekulė in the printerspausdintuvas usingnaudojant this softwareprograminė įranga.
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Taigi, naudodamiesi šia programine įranga, galėtume patalpinti tą molekulę į spausdintuvą.
01:55
So what could this mean?
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Ir ką gi tai galėtų reikšti?
01:58
Well, ultimatelygaliausiai, it could mean that you could printspausdinti your ownsavo medicinevaistas.
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Na, galų gale tai galėtų virsti galimybe jums patiems pasigaminti vaistus.
02:03
And this is what we're doing in the lablaboratorija at the momentmomentas.
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Ir būtent tuo mes užsiimame savo laboratorijoje.
02:05
But to take babykūdikis stepsžingsniai to get there,
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Bet, kad kūdikio žingsniais pasiektume tą tikslą,
02:06
first of all we want to look at drugvaistas designdizainas and productiongamyba,
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visų pirma mes norime pažvelgti į vaistų kūrimą ir gamybą,
02:09
or drugvaistas discoveryatradimas and manufacturinggamyba.
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arba vaistų atradimą ir gamybą.
02:12
Because if we can manufacturegaminti it after we'vemes turime discoveredatrado it,
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Nes jei vaistą atradus galime jį pagaminti,
02:15
we could deploydiegti it anywherebet kur.
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mes galime tai atlikti bet kur.
02:17
You don't need to go to the chemistchemikas anymoredaugiau.
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Nebereikėtų eiti pas vaistininką.
02:19
We can printspausdinti drugsnarkotikai at pointtaškas of need.
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Galėtume atsispausdinti vaistus vos prireikus.
02:22
We can downloadparsisiųsti newnaujas diagnosticsdiagnostika.
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Galėtume parsisiųsti naujausius diagnostinius duomenis.
02:24
Say a newnaujas supersuper bugklaida has emergedatsirado.
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Tarkime, jog atsirado naujas galingas užkrėtėjas.
02:26
You put it in your searchPaieška enginevariklis,
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Jūs įvedate jo duomenis į savo paieškos sistemą,
02:28
and you createsukurti the drugvaistas to treatgydyk the threatgrėsmė.
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ir sukuriate vaistą tai ligai.
02:31
So this allowsleidžia you on-the-flybrastas molecularmolekulinė assemblysurinkimas.
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Ir visa tai leidžia iškart susidėlioti molekulę.
02:35
But perhapsgalbūt for me the corebranduolys bitšiek tiek going into the futureateitis
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Bet, galbūt, esminis dalykas man, kalbant apie ateitį,
02:38
is this ideaidėja of takingpasiimti your ownsavo stemstiebas cellsląstelės,
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yra galimybė paimti savo paties kamienines ląsteles,
02:41
with your genesgenai and your environmentaplinka,
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savo genus ir aplinkos duomenis
02:43
and you printspausdinti your ownsavo personalasmeninis medicinevaistas.
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ir atsispausdinti vaistus būtent sau.
02:46
And if that doesn't seematrodo fancifulišgalvotas enoughpakankamai,
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Ir jei tai dar neatrodo pakankamai įmantriai,
02:48
where do you think we're going to go?
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kaip jūs manote, ką mes galime nuveikti su visu tuo?
02:50
Well, you're going to have your ownsavo personalasmeninis matterklausimas fabricatorgamintojas.
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Na, galėtume turėti savo asmeninę materijos gaminimo mašiną.
02:55
BeamŠviesos me up, ScottySkotas.
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Švystelk mane iš čia, Skoti.
02:57
(ApplausePlojimai)
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(Aplodismentai)
Translated by Andrius Družinis
Reviewed by Mindaugas Milasius

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ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com

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