ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com
TEDGlobal 2012

Lee Cronin: Print your own medicine

Lee Cronin:印出你的專屬藥物

Filmed:
1,045,687 views

化學家Lee Cronin正在研究一種3D印表機,不印出物體而是能夠印出化學分子。一個有潛力的讓人興奮的長期應用是:用化學連接印出屬於你個人的藥物。
- Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life. Full bio

Double-click the English transcript below to play the video.

00:16
Organic有機 chemists化學家 make molecules分子,
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有機化學家製做化學分子,
00:19
very complicated複雜 molecules分子,
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非常複雜的分子,
00:21
by chopping斬波 up a big molecule分子 into small molecules分子
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是藉由把大分子剪成許多小分子
00:24
and reverse相反 engineering工程.
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然後逆向工程。
00:26
And as a chemist化學家,
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而作為一個化學家,
00:27
one of the things I wanted to ask my research研究 group a couple一對 of years年份 ago is,
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其中一件我幾年前想要在我的研究團隊中探討的
00:31
could we make a really cool universal普遍 chemistry化學 set?
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就是我們是否可以製做一個很酷的通用化學機?
00:35
In essence本質, could we "app應用" chemistry化學?
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簡單來說,我們是否可以「應用」 化學?
00:40
Now what would this mean, and how would we do it?
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現在這代表什麼,而且我們該如何作呢?
00:43
Well to start開始 to do this,
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是這樣為了要開始做這個,
00:45
we took a 3D printer打印機
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我們找來一架3D印表機
00:47
and we started開始 to print打印 our beakers燒杯 and our test測試 tubes on one side
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而且我們開始在一邊印我們的燒杯和試管
00:51
and then print打印 the molecule分子 at the same相同 time on the other side
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接著同時在另一邊印出分子
00:55
and combine結合 them together一起 in what we call reactionwarereactionware.
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然後在我們所稱作反應儀的裡面將它們結合在一起。
00:58
And so by printing印花 the vessel船隻 and doing the chemistry化學 at the same相同 time,
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所以藉由同時印出容器和做化學合成,
01:03
we may可能 start開始 to access訪問 this universal普遍 toolkit工具包 of chemistry化學.
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我們或許開始進入這化學的通用工具箱。
01:08
Now what could this mean?
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現在這代表什麼呢?
01:09
Well if we can embed biological生物 and chemical化學 networks網絡 like a search搜索 engine發動機,
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這個嘛,如果我們可以將生物和化學的關聯網絡
如搜尋引擎般嵌入,
01:15
so if you have a cell細胞 that's ill生病 that you need to cure治愈
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所以如果你有一個你需要治療的細胞
01:18
or bacteria that you want to kill,
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或者是你希望殺死的細菌,
01:20
if you have this embedded嵌入式 in your device設備
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如果你有這個嵌入在你的儀器
01:22
at the same相同 time, and you do the chemistry化學,
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而你就在同時進行化學反應,
01:24
you may可能 be able能夠 to make drugs毒品 in a new way.
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你或許可以用一個新的方法製造藥物。
01:28
So how are we doing this in the lab實驗室?
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所以我們如何在實驗室裡做這件事?
01:30
Well it requires要求 software軟件, it requires要求 hardware硬件
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嗯,這需要軟體,這也需要硬體
01:33
and it requires要求 chemical化學 inks油墨.
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同時也需要有化學墨水。
01:36
And so the really cool bit is,
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所以那非常酷的一點是,
01:37
the idea理念 is that we want to have a universal普遍 set of inks油墨
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我們想要有一個通用性的墨水組的構想
01:40
that we put out with the printer打印機,
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當我們把它放上印表機,
01:43
and you download下載 the blueprint藍圖, the organic有機 chemistry化學 for that molecule分子
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而你下載藍圖,就是那個分子的有機化學
01:47
and you make it in the device設備.
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然後你在儀器中製造它。
01:50
And so you can make your molecule分子 in the printer打印機 using運用 this software軟件.
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因此你可以用這個軟體在印表機中製造你的分子。
01:55
So what could this mean?
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所以這代表著什麼呢?
01:58
Well, ultimately最終, it could mean that you could print打印 your own擁有 medicine醫學.
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嗯,終究,這可能代表你可以印出屬於你自己的藥物。
02:03
And this is what we're doing in the lab實驗室 at the moment時刻.
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而這就是我們當下正在實驗室裡做的。
02:05
But to take baby寶寶 steps腳步 to get there,
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然而為著要達到那兒
要實行些小步驟,
02:06
first of all we want to look at drug藥物 design設計 and production生產,
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首先我們希望能檢視藥物的設計和製造,
02:09
or drug藥物 discovery發現 and manufacturing製造業.
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或者是藥物的發現和生產。
02:12
Because if we can manufacture製造 it after we've我們已經 discovered發現 it,
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因為如果在我們發現它之後我們可以生產,
02:15
we could deploy部署 it anywhere隨地.
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我們可以在任何地方應用它。
02:17
You don't need to go to the chemist化學家 anymore.
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你們再也不需要去找化學家。
02:19
We can print打印 drugs毒品 at point of need.
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我們能夠在需要的地方印出藥物。
02:22
We can download下載 new diagnostics診斷.
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我們可以下載新的診斷。
02:24
Say a new super bug竊聽器 has emerged出現.
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比如說有一種新的超級細菌開始流傳。
02:26
You put it in your search搜索 engine發動機,
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你把它放進你的搜尋引擎,
02:28
and you create創建 the drug藥物 to treat對待 the threat威脅.
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然後你就創造出治療這個威脅的藥。
02:31
So this allows允許 you on-the-fly在即時 molecular分子 assembly部件.
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因此這就允許你快速地做同步分子組裝。
02:35
But perhaps也許 for me the core核心 bit going into the future未來
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但是或許對我來說展望未來中最核心的構想
02:38
is this idea理念 of taking服用 your own擁有 stem cells細胞,
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是這個用你自己的幹細胞
02:41
with your genes基因 and your environment環境,
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和你的基因以及你的環境,
02:43
and you print打印 your own擁有 personal個人 medicine醫學.
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你就可以印出屬於你個人的藥物。
02:46
And if that doesn't seem似乎 fanciful撒嬌的 enough足夠,
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然後如果那看來還不夠奇異,
02:48
where do you think we're going to go?
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你想我們還能夠去哪裡呢?
02:50
Well, you're going to have your own擁有 personal個人 matter fabricator製造者.
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嗯,你們將會有屬於你們的個人物質製造機。
02:55
Beam光束 me up, Scotty.
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傳送我吧,史考特。
02:57
(Applause掌聲)
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(鼓掌)
Translated by Amy Gong
Reviewed by Jephian Lin

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ABOUT THE SPEAKER
Lee Cronin - Chemist
A professor of chemistry, nanoscience and chemical complexity, Lee Cronin and his research group investigate how chemistry can revolutionize modern technology and even create life.

Why you should listen

Lee Cronin's lab at the University of Glasgow does cutting-edge research into how complex chemical systems, created from non-biological building blocks, can have real-world applications with wide impact. At TEDGlobal 2012, Cronin shared some of the lab's latest work: creating a 3D printer for molecules. This device -- which has been prototyped -- can download plans for molecules and print them, in the same way that a 3D printer creates objects. In the future, Cronin says this technology could potentially be used to print medicine -- cheaply and wherever it is needed. As Cronin says: "What Apple did for music, I'd like to do for the discovery and distribution of prescription drugs."

At TEDGlobal 2011, Cronin shared his lab's bold plan to create life. At the moment, bacteria is the minimum unit of life -- the smallest chemical unit that can undergo evolution. But in Cronin's emerging field, he's thinking about forms of life that won't be biological. To explore this, and to try to understand how life itself originated from chemicals, Cronin and others are attempting to create truly artificial life from completely non-biological chemistries that mimic the behavior of natural cells. They call these chemical cells, or Chells. 

Cronin's research interests also encompass self-assembly and self-growing structures -- the better to assemble life at nanoscale. At the University of Glasgow, this work on crystal structures is producing a raft of papers from his research group. He says: "Basically one of my longstanding research goals is to understand how life emerged on planet Earth and re-create the process."

Read the papers referenced in his TEDGlobal 2102 talk:

Integrated 3D-printed reactionware for chemical synthesis and analysis, Nature Chemistry

Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices, Lab on a Chip

More profile about the speaker
Lee Cronin | Speaker | TED.com

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