Adam de la Zerda: We can start winning the war against cancer
Adam de la Zerda: Kansere karşı savaşı kazanmaya başlayabiliriz
Adam de la Zerda develops new medical imaging technologies to detect and destroy cancer. Full bio
Double-click the English transcript below to play the video.
and the National Cancer Institute declared
Enstitüsü'nün birkaç yıl önce,
but I don't buy that.
ben inanmıyorum.
anyone here will question that.
biri bundan şüphe etmez.
yenemediğimiz
this war against cancer
a story about a good friend of mine.
kıssayı paylaşarak başlayacağım.
Ehud was diagnosed with brain cancer.
beyin kanseri teşhisi kondu.
of the most deadly forms of brain cancer.
ölümcül türlerinden biriyle.
that they only have 12 months,
kaldığını söylediler
they have to find a treatment.
tedavi bulmak zorundaydılar.
find a cure, he will die.
of different treatments to choose from,
tedavi yöntemi vardı
if a treatment is even working or not,
about three months or so.
into his first treatment,
just a few days into that treatment,
tedavinin daha ilk günlerinde
"Adam, I think this is working.
"Adam, bence oluyor.
Something is happening."
Bir şeyler oluyor." dedi.
How do you know that, Ehud?"
Nasıl anladın Ehud?"
I feel so terrible inside.
we got the news, it didn't work.
işe yaramadığı haberini aldık.
into his second treatment.
gotta be working there."
çalışıyor olmalı."
again we get bad news.
kötü haberleri aldık.
and then his fourth treatment.
4. tedavisine girdi.
Ehud öldü.
is going through such a huge struggle,
are going through your head.
this is the best that we can offer?
kısmına sinirlendim.
more and more into this.
the best that doctors could offer Ehud.
yapabildiğinin en iyisi bu değilmiş.
patients with brain cancer generally.
en iyisi sadece bu değilmiş.
all across the board with cancer.
iyi değilmişiz.
have seen those statistics before.
how many patients actually died of cancer,
öldüğünü gösterecek,
that many things that have changed.
fark edeceksiniz.
for example, on the rise.
for example, stomach cancer
öldürücülerinden olan
of the biggest killers of all cancers,
Anyone knows, by the way?
struck by stomach cancer?
kanserinden muzdarip değil?
medical technology breakthrough
kanserinden kurtaran
that saved humanity from stomach cancer?
atılım neydi?
or a better diagnostic?
yoksa daha iyi bir tanı mıydı?
no longer eating spoiled meats.
that happened to us so far
araştırmasındaki tıbbi
the refrigerator was invented.
in cancer research.
of good cancer research
başlıca şeyleri bize
that taught us about cancer.
to still do ahead of us.
yük olduğunu söyledi.
reason why this is the case,
birincil sebep neden konunun
medical imaging comes in.
devreye giriyor.
of the best medical imaging
hastalarına sağlanan en iyi
to brain cancer patients,
bir fikir vermek için
to all cancer patients,
where the bones are,
nerede olduğunu ve
nerede olduğunu gösterecektir.
where tumors are.
outside of the body,
into these patients by the billions,
milyarlar tarafından enjekte olur
that are hungry for sugar.
for example, lights up there.
parladığını görebilirsiniz.
needs a lot of sugar.
lights up there.
görebilirsiniz.
is the thing that's clearing
vücuttan şekeri
a wonderful technology.
to look into someone's body
hücrelerin her birini alıp
each and every one of the cells
allowing us to look into someone's body
birinin vücuduna bakıp
has the cancer metastasized?
are showing you very clearly
etkin noktaların, tümörün
where is the tumor.
small little hot spots there.
etkin noktaları görüyorsunuz.
are in any one of these tumors?
tahmin edebilir misiniz?
that this number sunk in.
of these small little blips
at least 100 million cancer cells
like a very large number,
an incredibly large number,
büyük sayılar,
in order to pick up something early enough
kadar erken yakalamak,
to do something meaningful about it,
mantıklı bir şeyler yapabilmek için
that are a thousand cells in size,
boyutundayken yakalamamız lazım
avuç kadar hücre boyutunda.
a handful of cells in size.
pretty far away from this.
a little experiment here.
to now play and imagine
that the tumor is out.
alındığından emin olmak.
have already been removed,
about the size of a golf ball or so
of this person's brain.
everything looks the same,
her şey aynı görünüyor,
and healthy brain tissue
sağlıklı beyin dokusu
a little bit on the brain,
a little harder, stiffer,
daha sert ve gergin olma
a little bit like this and say,
şekilde girip şöyle dersiniz:
and start cutting the tumor
tümörü parça parça
to a stage where you think,
I took out everything."
Her şeyi çıkardım."
like, pretty crazy --
kulağa oldukça çılgınca geldi--
challenging decision of your life here.
kararıyla yüzleşmek üzeresin.
and let this patient go,
kanserli hücre
some leftover cancer cells behind
olarak her şeyi
around the tumor
have to take every single day
to a few friends of mine in the lab,
sohbet ettiğimizi
there's got to be a better way."
"Daha iyi bir yolu olmalı." dedik.
daha iyi bir yolu olmak demek gibi değil.
that there's got to be a better way.
the sugar and so on.
şekeri falan hatırlayın.
instead of using sugar molecules,
kullanmak yerine
little particles made of gold,
tanecikleri alalım
interesting chemistry around them.
ile onları programlayalım.
to look for cancer cells.
programlayalım.
these gold particles
every single cell in our body
or are you a healthy cell?
kanserli bir hücre misin?
yapışıp parlıyoruz ve
we're sticking in and shining out
"Hey, look at me, I'm here."
diyoruz.
through some interesting cameras
geliştirdiğimiz bazı ilginç
belki de beyin cerrahlarını yalnız
maybe we can guide brain cancer surgeons
and leaving the healthy brain alone.
kısmı bırakmaları için yönlendirebiliriz.
and boy, this works well.
into this mouse's brain
growing in this mouse's brain,
and asked the doctor
as if that was a patient,
ameliyat etmesini
out of the tumor.
almasını istedik.
to see where the gold particles are.
görmek için resimler alacağız.
into this mouse,
etmeyle başlıyoruz
right here at the very left there
where the gold particles are.
is that these gold particles
"Hey, we're here. Here's the tumor."
İşte tümör." diyorlar.
to the doctor yet.
bunu göstermiyoruz.
now please start cutting away the tumor,
tümörü almaya başlamasını istiyoruz
doktor tümörün dörtte birini aldı
just took the first quadrant of the tumor
is now missing.
çeyreği aldı ve üçüncüyü,
the second quadrant, the third,
the doctor came back to us and said,
Ne yapmamı istiyorsunuz?
What do you want me to do?
some extra margins around?"
alayım mı?" dedi ve
"You've missed those two spots,
"Şu iki noktayı kaçırmışsın,
and then let's take a look."
and lo and behold,
that the cancer is completely gone
huge amounts of healthy brain
kısmınında çoğunu
as they take away a tumor,
bilerek operasyon yaptıkları
have to guess with their thumb.
etmek zorunda değiller.
to take those tiny little leftover tumors.
bizim için şu yüzden önemli;
even if it's just a handful of cells,
avuç kadar bile olsa
ultimately fail
extra margins that were left positive,
kalmasındandır,
that were left there.
is where I think we're heading from here.
buradan nereye yol alacağımız.
what should we be working on now?
neye çalışmamız gerektiğini soruyoruz.
medical imaging is heading to
insan vücudunun içine bakıp
of these cells separately.
doğru ilerliyor.
way, way earlier in the process,
içinde 100 milyon hücre olmasından
so we can actually do something about it.
bir şeyler yapabiliriz.
of the cells might also allow us
we are now getting to a point
noktaya geliyoruz ki;
these cancer cells real questions,
sormaya başlayabiliriz,
to the treatment we are giving you or not?
karşılık veriyor musun gibi.
hemen tedaviyi durdururuz
to stop the treatment right away,
nasty, nasty chemotherapy drugs,
side effects of the drugs
in fact not even helping them.
yararı olmadığı zamanlarda.
from winning the war against cancer,
yenmekten oldukça uzağız,
with better medical imaging techniques
iyi tıbbi görüntüleme
ABOUT THE SPEAKER
Adam de la Zerda - Biologist, electrical engineerAdam de la Zerda develops new medical imaging technologies to detect and destroy cancer.
Why you should listen
Adam de la Zerda is an assistant professor at the Departments of Structural Biology and Electrical Engineering (courtesy) at Stanford University – School of Medicine. He completed his undergraduate degree in computer engineering and physics from the Technion – Israel Institute of Technology in 2005 Summa Cum Laude. He received his Ph.D. in Electrical Engineering from Stanford University in 2011, where he developed the Photoacoustic Molecular Imaging technique with Sanjiv Sam Gambhir. He was then a postdoctoral fellow at the lab of Carolyn Bertozzi at UC Berkeley – Chemistry Department, before joining the Stanford faculty in 2012.
de la Zerda's research interests span the broad field of molecular imaging. His lab focuses on developing new optical imaging instrumentation and chemistry tools to study the complex spatiotemporal behavior of biomolecules in living subjects. The lab uses animal models for cancer and ophthalmic diseases such as age-related macular degeneration. His research efforts span both basic science and clinically translatable work.
de la Zerda has received many awards and honors for his work, including the Pew-Stewart Scholar for Cancer Research, the AFOSR Young Investigator Award, Baxter Faculty Scholar Award, Dale F. Frey Award, Forbes Magazine 30 Under 30 in Science and Healthcare for 2012 and 2014, NIH Director’s Early Independence Award, Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, Era of Hope Distinguished Predoctoral Poster Award, Best Poster Presentation at SPIE Photonics West, the Young Investigator Award at the World Molecular Imaging Congress, the Department of Defense Breast Cancer Research Program Award for Predoctoral researchers, the Bio-X Graduate Student Fellowship and first place at the Bay Area Entrepreneurship Contest. He has published papers in leading journals including Nature Medicine, Nature Nanotechnology and PNAS. He holds a number of patents and is the founder of a medical device company, Click Diagnostics.
Adam de la Zerda | Speaker | TED.com