Jocelyne Bloch: The brain may be able to repair itself -- with help
ژاسلین بلوش: شاید مغز -با کمی کمک - بتواند خود را بازسازی کند
Jocelyne Bloch is helping to unlock potential self-healing capacities of the human brain. Full bio
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with human tragedies.
from one second to the other
یک لحظه به لحظهی بعد تغییر کنه
or after a car accident.
for us neurosurgeons
مأیوسکننده هست
other organs of the body,
ability for self-repair.
خودش داره.
of your central nervous system,
with a severe handicap.
باقی میمونه.
the reason why I've chosen
تصمیم گرفتم
a neurological function
one of the famous ones
in the depths of the brain
the destiny of patients
does not mean neuro-repair.
بازسازی عصبی نیست.
in the emergency room.
of patients with head trauma.
وارد شده بود مراقبت میکردم.
comes in with a severe head trauma,
شدید به سر وارد میشه،
his intracranial pressure.
this intracranial pressure.
پایین بیارید.
a piece of swollen brain.
کرده را بردارید.
these pieces of swollen brain,
from these pieces of tissue.
سلول رشد بدهیم.
very small children
to make them thrive.
تا شکوفا شوند.
to do with these cells.
سلولها میکردیم.
under his microscope.
as a stem cell culture,
است،
surrounding small, immature cells.
نابالغ را احاطه کردهاند.
of cell of the body.
تبدیل شوند.
but they're very rare
اما خیلی نادر هستند
in deep and small niches
this kind of stem cell culture
سلولهای بنیادی را
of swollen brain we had
intriguing observation:
are very active cells --
divide very quickly.
تقسیم میشوند، خیلی سریع تقسیم میشوند.
they're immortal cells.
new cell population
جلومون داشتیم
but behaved differently.
رفتار متفاوتی داشتند.
to understand where they came from.
کجا آمدهاند.
doublecortin-positive cells.
دَبِل کورتین مثبت نام دارند.
of your cortical brain cells.
تشکیل میدهند.
during the development stage.
دارند.
participate in brain repair
شرکت کنند
in higher concentration
of a potential new source of cells
an experimental paradigm.
سخنوری نیست
did it in his lab.
آزمایشگاهش انجام داد.
to track them in the brain.
these cells in a normal brain,
پیوند بزنیم چی میشه،
if we re-implant the same cells
چی میشه؟»
چی میشه؟»
of professor Eric Rouiller,
in the normal brain
disappeared after a few weeks,
ناپدید شدند،
so they disappear.
پس ناپدید میشوند.
we could observe under the microscope.
میتونستیم ببینیم.
that were re-implanted.
زده شدهاند.
are the cells that we've labeled
ما نشاندار کردیم.
to recover after a lesion?
که بعد از آسیب بهبود پیدا کنه؟
to perform a manual dexterity task.
را آموزش دادیم
food pellets from a tray.
بردارند.
a plateau of performance,
corresponding to the hand motion.
حرکت دست است آسیب میزنیم.
to a certain extent,
due to a brain plasticity mechanism,
انعاطافپذیری مغز بهتر بشوند.
had reached his plateau
میمونها به
that has spontaneously recovered.
خودبخود بهبود پیدا کرده.
of his previous performance
پیوند زدیم:
the same individual.
for us, I tell you.
هیجانانگیزی بودند.
much more about these cells.
سلولها آموختهایم.
یخزده حفظ کنیم.
in other neuropathological models,
عصبی دیگر هم از آنها استفاده کنیم،
to implant them in humans.
پیوندشان بزنیم.
to show you soon
به شما نشان بدم
the tools to repair itself.
را میدهد.
several dozen people in the audience,
جمع شنوندهها هستند،
somebody who can use this."
میتونه از این استفاده کنه.»
into human clinical trials?
بالینی در انسان بروید؟
obstacles are regulations. (Laughs)
مانع قوانین هستند. (میخندد)
you need to fill out
kind of trials.
the brain is delicate, etc.
a professional team to do it, you know?
و یک تیم تقریباً حرفهای، میدونید؟
permission to start the trials,
اجازه بگیرید،
somebody gets into a hospital
به بیمارستان بره
on the approval of the trial.
to do it soon?
انجامش دهیم؟
this kind of study
to select the patients,
بیماران را انتخاب کنیم
to do this kind of treatment.
به درد میخوره؟
this to a multicentric trial.
ببرید.
first that it's useful
up for everybody.
بشه.
to TED and sharing this.
و کارتان را به اشتراک گذاشتید.
ABOUT THE SPEAKER
Jocelyne Bloch - Functional neurosurgeonJocelyne Bloch is helping to unlock potential self-healing capacities of the human brain.
Why you should listen
Swiss neurosurgeon Jocelyne Bloch is an expert in deep brain stimulation and neuromodulation for movement disorders. Her recent work focuses on cortical cells, called doublecortin, related to neurogenesis and brain repair. In collaboration with Jean François Brunet and others, she is pioneering the development of adult brain cell transplantation for patients with stroke, using their own stem cells. She aims at gathering all these novel therapeutic strategies under a common umbrella that will optimize treatment options for patients suffering from neurological impairments. She is in charge of the functional neurosurgery unit at the Lausanne University Hospital (CHUV).
Jocelyne Bloch | Speaker | TED.com